Results 41 to 50 of about 4,260 (165)

In vitro and in vivo laboratory models for Orthopoxviruses (Poxviridae: Orthopoxvirus): current approaches, limitations, and future perspectives

Вопросы вирусологии
The article presents a review of modern experimental models used for the study of orthopoxvirus infections. The biological characteristics and pathogenesis of orthopoxviruses are discussed, including mechanisms of replication, immune evasion, and ...
Sanat S. Kilibayev, Moldir S. Tuyskanova, Moldyr A. Azanbekova, Kuandyk D. Zhugunissov   +3 more
doaj   +1 more source

Early Mpox Detection: Integrating Skin Lesion Imaging, Epidemiology, and Treatment for Deep Learning Approaches

Medicine Advances, Volume 4, Issue 3, Page 287-296, September 2026.
Research papers utilizing publicly available, web‐scraped resources related to mpox—including news portals and datasets such as Monkeypox2022, Kaggle, and the Monkeypox Skin Images Dataset—demonstrate variability in accuracy. Our findings suggest that although deep learning models such as MobileNetV2, VGG16, and GoogLeNet report accuracy exceeding 95%,
Taskin Sabit, Faiza Tasnim
wiley   +1 more source

Epidemiological Aspects and Basic Directions of the Protective Medications against Monkeypox Development

Эпидемиология и вакцинопрофилактика
Relevance. After smallpox eradication, in conditions of population immunity to orthopoxviruses absence, Monkeypox virus became most significant orthopoxvirus, pathogenic for humans. Therefore the generalization of data on the areas of infection outbreaks,
L. F. Stovba, A. A. Petrov, N. K. Cherniкova, A. L. Khmelev, S. L. Kuznetsov, S. V. Borisevich   +5 more
doaj   +1 more source

Durability of the Humoral Response to MPXV Infection

Journal of the International AIDS Society, Volume 29, Issue S2, July 2026.
ABSTRACT Introduction Mpox virus (MPXV) re‐emerged in endemic countries in recent decades, resulting in large outbreaks in central and western Africa and a worldwide epidemic of clade IIb MPXV starting in 2022. Mpox cases in vaccinated persons, and a few documented reinfections, have raised questions about the durability of MPXV humoral immunity ...
Tara N. Palmore
wiley   +1 more source

Introduction of the Pelleted Smallpox Vaccine TEOVak into Serial Production to Provide Biosafety of the Population of the Russian Federation

Проблемы особо опасных инфекций, 2010
The industrial basis was developed and licensed to produce effective pelleted oral smallpox vaccine TEOVak in the Virologic Centre. Several series of TEOVak preparation were produced in accordance with the industrial technology on a built-in processing ...
V. P. Bondarev, A. I. Terent`ev, S. A. Melnicov, T. A. Bondareva   +3 more
doaj   +1 more source

Discovery and Structural Characterization of a Highly Protective Neutralizing Antibody Targeting the Mpox Virus A35R Protein

MedComm, Volume 7, Issue 7, July 2026.
High‐affinity monoclonal antibodies (mAbs) targeting the MPXV EEV protein A35R were rapidly isolated using mRNA‐LNP vaccination and the Beacon single‐cell sorting Optofluidic platform, followed by functional profiling. One mAb, 17H1, potently neutralized authentic MPXV and conferred complete protection in vivo.
Shimeng Bai, Shuo Song, Xin Wang, Yuxin Xiao, Yun Long, Fenfang Wu, Fuxiang Wang, Zhongyi Fan, Jianqing Xu, Maozhou He, Hongzhou Lu   +10 more
wiley   +1 more source

Synthesis and Antiviral Evaluation of Alkoxyalkyl Derivatives of 9-(S)-(3-Hydroxy-2-phosphonomethoxypropyl)adenine against Cytomegalovirus and Orthopoxviruses

, 2016
9-(S)-(3-Hydroxy-2-phosphonomethoxypropyl)adenine [(S)-HPMPA] was one of the first acyclic nucleoside phosphonates described and has been reported to have good antiviral activity against most double-stranded DNA viruses, including the herpes group ...
James R. Beadle (2229292), Earl R. Kern (2497402), Stephanie L. Ciesla (2646310), William B. Wan (2646307), Caroll Hartline (2646304), Kathy A. Keith (2497426), Karl Y. Hostetler (2229289)   +6 more
core   +1 more source

Analysis of aerobiological studies with orthopoxviruses by U.S. Department of Defense

Журнал микробиологии, эпидемиологии и иммунобиологии
Discontinuation of vaccination after the completion of Smallpox global eradication program led to a sharp decrease in the level of collective immunity not only to smallpox but also to other orthopoxvirus infections.
Gennady G. Onishenko, Igor A. Kirillov, Sergey V. Borisevich, Tatiana E. Sizikova, Victor T. Krotkov   +4 more
doaj   +1 more source

In Silico Design and Computational Characterization of Novel Chimeric Multiepitope Antigens for Mpox Serosurveillance: An Immunoinformatics Approach

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background and Aims The Monkeypox (Mpox) virus is a zoonotic Orthopoxvirus with a global outbreak that began in 2022, with more than 132,000 confirmed cases and 1500 deaths across over 128 countries. The pandemic preparedness pipeline emphasizes the importance of diagnostic surveillance of pathogens in at‐risk populations to monitor ...
Roland Ngwese Akwelle, Robert Adamu Shey, Mary Teke Efeti, Lekeayi Nelson Acha, Gordon Takop Nchanji, Yanick Aqua Stong Tangan, Joan Amban Chick, Ntang Emmaculate Yaah, Lahngong Methodius Shinyuy, Cabirou Mounchili Shintouo, Bernis Neneyoh Yengo, Abey Blessings Ayuk, Junior Ekunidi Engarimbi, Ketura Yaje Gwei, Brinate Teke Tebo, Derrick Neba Nebangwa, Beltine Muyer Tamnjong, Luc Vanhamme, Jacob Souopgui, Vincent P. K. Titanji, Stephen Mbigha Ghogomu   +20 more
wiley   +1 more source

Trends of Pathogenicity and Potential Risk Evaluation of Central African Mpox Variant to Cause Global Public Health Emergency: A Cross‐Sectional Analysis

Health Science Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background With the re‐emergence of monkeypox (Mpox), it is vital for communities to assess and effectively respond to emerging outbreaks. This paper aims to review the potential of clade I Mpox to result in a widespread outbreak by assessing genetically enhanced virulence, transmission, and clinical manifestations.
Md. Ashrafur Rahman, Carlie Kozlowich, Nicholas Katulka, Marie Roke Thomas, Yeasna Shanjana, Md. Rabiul Islam   +5 more
wiley   +1 more source