Results 61 to 70 of about 4,260 (165)

Mpox in South Asia: A Narrative Review on Epidemiology, Preparedness, and Preventive Strategies

Health Science Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Background and Aims Monkeypox (Mpox), due to its growing global concern, was declared a public health emergency of worldwide concern by the World Health Organization in August 2024. The monkeypox virus (MPXV), once limited to African regions, has now spread to South Asia, including Pakistan, India, Nepal, and Sri Lanka, and there have been ...
Jannatul Mawa, Shariun Nahar Rimun, Nujhat Zayma Rahman, Mohiuddin Ahmed Bhuiyan, Mohammad Shahriar, Ramisa Anjum   +5 more
wiley   +1 more source

Evaluation and Clinical Validation of Pan‐Specific and Clade‐Specific Diagnostic Real‐Time PCR Assays for Monkeypox Virus

Journal of Medical Virology, Volume 98, Issue 4, April 2026.
ABSTRACT Human mpox, formerly known as monkeypox, has twice been declared a Public Health Emergency of International Concern (PHEIC) by the World Health Organization, in 2022 and 2024. Despite this, global access to rapid, reliable diagnostics remains limited, hindering outbreak control and equitable clinical response. To address this gap, we developed
Hong Chang, Tin Hang Hung, Binbin Li, Bobby Lim‐Ho Kong, Ashwathi Asha Madhaven, Yue Wang, Ming‐shan Tsai, Dan Deng, Zhanfeng Cui   +8 more
wiley   +1 more source

IgA Antibodies Reveal Covert Infection With Mpox Virus in People Living With HIV in the Community: A Prospective Longitudinal Cohort Survey

MedComm, Volume 7, Issue 4, April 2026.
This study identified covert infection of MPXV among people living with HIV and MPXV‐IgA was the effective indicator. The combined use of two antigen protein set of MPXV (B6R plus E8L and E8L plus H3L) yield IgA test results comparable to those obtained with the MPXV.
Rui Song, Danyang Li, Lan Chen, Xiao Wang, Qiao Zhang, Zhixia Gu, Xueqi Chi, Yuanyuan Zhang, Jing Han, Li Guo, Ronghua Jin, Lili Ren, Jianwei Wang   +12 more
wiley   +1 more source

An mRNA Vaccine Based on Antigens From Conserved Regions of Monkeypox Virus A35R and M1R With a Dimer‐Like Conformation Confers Protection Against Both Monkeypox Virus and Vaccinia Virus Infections in Mice

MedComm, Volume 7, Issue 2, February 2026.
We developed four candidate mRNA vaccine antigens based on conserved sequences of MPXV A35R and M1R proteins. Our findings demonstrate that the MV2 vaccine possesses favorable immunogenicity and prophylactic potential against MPXV and VACV infections, positioning it as a promising clinical candidate for MPXV prevention.
Cong Tang, Longhai Yuan, Yun Xie, Yun Yang, Yanan Zhou, Junbing Wang, Hao Yang, Rui Peng, Jiali Xu, Wenhai Yu, Qing Huang, Wenqi Quan, Baisheng Li, Youchun Wang, Shuaiyao Lu   +14 more
wiley   +1 more source

The Disease Ecology, Epidemiology, Clinical Manifestations, Management, Prevention, and Control of Increasing Human Infections with Animal Orthopoxviruses

, 2021
Zoonotic orthopoxvirus outbreaks have occurred repeatedly worldwide, including monkeypox in Africa and the United States, cowpox in Europe, camelpox in the Middle East and India, buffalopox in India, vaccinia in South America, and novel emerging ...
Diaz, James H.
core   +1 more source

Monoclonal Antibodies in Light of Mpox Outbreak: Current Research, Therapeutic Targets, and Animal Models

Antibodies
The rapid rise in monkeypox virus infections among humans from 2022 to 2024 has captured the attention of the global healthcare community. In light of the lack of mandatory vaccination and limited data on next-generation vaccines for monkeypox prevention,
Vladimir N. Nikitin, Iuliia A. Merkuleva, Dmitriy N. Shcherbakov   +2 more
doaj   +1 more source

Blocking Lysine Crotonylation and Aerobic Glycolysis as Targeting Strategy Against mpox Virus Replication

Advanced Science, Volume 13, Issue 4, 19 January 2026.
Wei et al. report that MPXV infection induces aerobic glycolysis, a process mediated by the viral protein I3 through lysine crotonylation at its K102 residue. The acetyltransferase MYST1 catalyzes the crotonylation of I3 to inhibit the ubiquitin‐mediated degradation of WDR26.
Pengjun Wei, Zongzheng Zhao, Ruoqi Xu, Qin Yan, Liangzi Jiang, Fuxiao Geng, Yang Gu, Tianjiao Wang, Jing Zhou, Xiao Li, Qin Yan, Chun Lu, Wan Li   +12 more
wiley   +1 more source

Monkeypox Virus in Nigeria: Infection Biology, Epidemiology, and Evolution

Viruses, 2020
Monkeypox is a zoonotic disease caused by monkeypox virus (MPXV), which is a member of orthopoxvirus genus. The reemergence of MPXV in 2017 (at Bayelsa state) after 39 years of no reported case in Nigeria, and the export of travelers’ monkeypox (MPX ...
Emmanuel Alakunle, Ugo Moens, Godwin Nchinda, Malachy Ifeanyi Okeke   +3 more
doaj   +1 more source

Оrthopoxviruses of New World: review of scientific literature

Эпидемиология и вакцинопрофилактика
Relevance. 3 agents raccoonpox, skunkpox and volepox belonged to orthopoxviruses of the New World until 2015 years. In last ten-years period skunkpox virus using as vector for creation recombinant vaccines for animals.
L. F. Stovba, O. V. Chukhralia, A. A. Petrov, S. A. Melnikov, D. P. Belozerov, M. A. Filippova, V. A. Kovalchuk, S. V. Borisevich   +7 more
doaj   +1 more source

Strategic Preparedness of Broad‐Spectrum Antivirals for Rapid Response Towards Next Pandemics

Small Science, Volume 6, Issue 1, January 2026.
Nanoengineered broad‐spectrum antivirals (BSAs) represent a transformative approach to pandemic preparedness. Unlike virus‐specific drugs requiring separate development, BSAs act across multiple viral families through nanoengineering strategies that enhance solubility, bioavailability, and host‐targeted activity.
Sanoj Rejinold N, Geun‐woo Jin, Jin‐Ho Choy   +2 more
wiley   +1 more source