Results 81 to 90 of about 4,260 (165)

Clinical guidance for the use of JYNNEOS [PDF]

02-Orthopoxviruses-Petersen-508 ...

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DNA comparisons of the two orthopoxviruses monkeypox and variola [PDF]

, 1988
Although smallpox has been eradicated there are animal poxviruses which are closely related. It is desirable to measure the closeness of this relation to assess whether Variola virus could re-emerge as a complex mutant of an animal poxvirus.
Pare, Nicola Jennifer
core   +1 more source

TRIM5α: A Protean Architect of Viral Recognition and Innate Immunity

Viruses
The evolutionary pressures exerted by viral infections have led to the development of various cellular proteins with potent antiviral activities, some of which are known as antiviral restriction factors.
Stephanie J. Spada, Michael E. Grigg, Fadila Bouamr, Sonja M. Best, Peijun Zhang   +4 more
doaj   +1 more source

Kinetic analysis of a complete poxvirus transcriptome reveals an immediate-early class of genes [PDF]

, 2008
Vaccinia virus is the prototypic orthopoxvirus and was the vaccine used to eradicate smallpox, yet the expression profiles of many of its genes remain unknown.
V. Pasquetto, Pasquetto, Valerie, J. A. Hammond, A. Sette, Sette, Alessandro, Grey, Howard, Oseroff, Carla, Hammond, Jennifer A., B. Peters, M. Sundstrom, Schaffer, Lana, R. C. Hendrickson, J. A. Greenbaum, Greenbaum, Jason A., E. Assarsson, D. C. Tscharke, Head, Steven R., Peters, Bjoern, E. J. Lefkowitz, Tscharke, David, Hendrickson, R Curtis, J. Sidney, Sidney, John, C. Oseroff, Lefkowitz, Elliot J, Sundstrom, Magnus, H. M. Grey, L. Schaffer, S. R. Head, Assarsson, Erika   +29 more
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Poxvirus Modulation of the Immune Response

, 2009
Orthopoxviruses encode many genes that are not essential for viral replication, which often account for differences in pathogenesis among otherwise closely related orthopoxviruses.
Spesock, April
core   +1 more source

Modulating Vaccinia Virus Immunomodulators to Improve Immunological Memory

Viruses, 2018
The increasing frequency of monkeypox virus infections, new outbreaks of other zoonotic orthopoxviruses and concern about the re-emergence of smallpox have prompted research into developing antiviral drugs and better vaccines against these viruses.
Jonas D. Albarnaz, Alice A. Torres, Geoffrey L. Smith   +2 more
doaj   +1 more source

Epidemiology of Camelpox: New Aspects

Вестник войск РХБ защиты
After the abolition of the mandatory smallpox vaccination, the humanity lost the immunity not only to smallpox, but also to infections caused by pathogens of this family (Orthopoxvirus): monkeypox, cowpox, buffalo pox, camelpox.
L. F. Stovba, V. N. Lebedev, O. V. Chukhralia, A. L. Khmelev, S. L. Kuznetsov, S. V. Borisevich   +5 more
doaj   +1 more source

Tecovirimat Guidance: Refer to Summary of Product Characteristics (SmPCs) of Tecovirimat for full prescribing information

, 2023
Tecovirimat inhibits p37, a protein that is present and highly conserved (approximately 98% amino acid identity) in all orthopoxviruses; the inhibition of p37 prevents the formation and egress of enveloped virions, which are essential for ...
Health Products Regulatory Authority (HPRA)
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Smallpox Research Activities: U.S. Interagency Collaboration, 2001

Emerging Infectious Diseases, 2002
James W. LeDuc, Inger K. Damon, James M. Meegan, David A. Relman, John Huggins, Peter B. Jahrling   +5 more
doaj   +1 more source

T Cell Responses against Orthopoxviruses in HIV-Positive Patients

A global outbreak of predominantly sexually transmitted mpox infections, outside endemic regions, was reported in May 2022. Thereafter, risk groups were vaccinated against smallpox, a structurally related orthopoxvirus.
Pia Schenk-Westkamp, Stefan Esser, Peter A. Horn, Monika Lindemann, Sammet Stefanie, Michael Koldehoff   +5 more
core   +1 more source