Results 111 to 120 of about 9,580 (245)

Report of meeting of the Study Group on Orthopoxvirus Research, Atlanta, 26-28 June 1979 [PDF]

In December 1978 the Global Commission for the Certification of Smallpox Eradication considered all aspects of the programme. One of the objectives of the Global Commission was "to recommend research activities regarding: possible animal reservoirs of ...

core  

Data from: Novel orthopoxvirus infection in an Alaska resident

, 2017
Background. Human infection by orthopoxviruses is being reported with increasing frequency, attributed in part to the cessation of smallpox vaccination and concomitant waning of population-level immunity.
Patel, Nishi, Mauldin, Matthew R., Li, Yu, Burgado, Jillybeth, Fowler, Nisha, Goldsmith, Cynthia S., Springer, Yuri P., McCollum, Andrea M., Olson, Link E., Doty, Jeffrey B., Castrodale, Louisa J., Satheshkumar, Panayampalli S., Wilkins, Kimberly, Emerson, Ginny L., McLaughlin, Joseph B., Hsu, Chris H., Gao, JinXin, Reynolds, Mary G., Cooper, Michael, Davidson, Whitni, Werle, Zach   +20 more
core   +1 more source

Insights into poxviruses: virology and vaccines

Acta Virologica
Due to the successful eradication of smallpox worldwide and the cessation of smallpox vaccination campaign in 1980, the human population seems to be more susceptible to poxvirus infection.
Adriana Manuka, Irsida Mehmeti, Antonia Radaelli, Eduart Hashorva, Carlo Zanotto, Carlo De Giuli Morghen   +5 more
doaj   +1 more source

Oncolytic Therapy: Delivery System and New Therapeutic Strategies for Cancer

MedComm, Volume 7, Issue 4, April 2026.
This review summarizes recent advances in nanoparticle‐ and cell‐mediated OVs delivery strategies that improve biodistribution and tumor targeting while limiting immune clearance. It also examines combination approaches that enhance therapeutic efficacy through tumor microenvironment modulation or immune activation, thereby overcoming immunosuppression
Sikan Jin, Yi Zhang, Ziling Zhou, Yaqi Zhang, Ting Yu, Rui Xu, Lin Xu, Jidong Zhang, Longze Zhang, Shan Yang, Xianyao Wang   +10 more
wiley   +1 more source

Novel Orthopoxvirus and Lethal Disease in Cat, Italy

Emerging Infectious Diseases, 2018
We report detection and full-genome characterization of a novel orthopoxvirus (OPXV) responsible for a fatal infection in a cat. The virus induced skin lesions histologically characterized by leukocyte infiltration and eosinophilic cytoplasmic inclusions.
Gianvito Lanave, Giulia Dowgier, Nicola Decaro, Francesco Albanese, Elisa Brogi, Antonio Parisi, Michele Losurdo, Antonio Lavazza, Vito Martella, Canio Buonavoglia, Gabriella Elia   +10 more
doaj   +1 more source

From actually toxic to highly specific – novel drugs against poxviruses

, 2007
The potential use of variola virus, the causative agent of smallpox, as a bioweapon and the endemic presence of monkeypox virus in Africa demonstrate the need for better therapies for orthopoxvirus infections. Chemotherapeutic approaches to control viral
Schnierle Barbara, Sliva Katja, Sliva, Katja, Schnierle, Barbara   +3 more
core   +1 more source

Efficacy of three key antiviral drugs used to treat orthopoxvirus infections: a systematic review

Global Biosecurity, 2019
Background: In a global political climate increasingly concerned about terrorism, bioterrorism agents such as smallpox would undoubtedly be catastrophic.
Joyce Yu, S. M. Raj
semanticscholar   +1 more source

Genomic Insights into the Spread of Vaccinia Virus Strain Cantagalo to Rural Regions of Northeastern Brazil

Viruses
Vaccinia virus strain Cantagalo (CTGV) causes a pustular disease in dairy cows and milkers in Brazil. Outbreaks in several states have been frequently reported, but the full genome sequence and genomic analysis of isolates from the Northeast region have ...
Maria Júlia Cadrieskt-Ribeiro, Matheus Nobrega Luques, Samuel Hir, Pedro Lucas O. Correia, Régis Linhares Oliveira, Carolina Maciel Neves, Keilla Maria P. Silva, Mayara Matias O. M. da Costa, Diego Arruda Falcão, Luciana Bahiense da Costa, Arabela Leal S. Mello, Jussara Lagos O. Silveira, Clarissa R. Damaso   +12 more
doaj   +1 more source

Dynamics of Pathological and Virological Findings During Experimental Calpox Virus Infection of Common Marmosets (Callithrix jacchus)

Viruses, 2017
Experimental intranasal infection of marmosets (Callithrix jacchus) with calpox virus results in fatal disease. Route and dose used for viral inoculation of the test animals mimics the natural transmission of smallpox, thus representing a suitable model ...
Anne Schmitt, Li Lin Gan, Ahmed Abd El Wahed, Tingchuan Shi, Heinz Ellerbrok, Franz-Josef Kaup, Christiane Stahl-Hennig, Kerstin Mätz-Rensing   +7 more
doaj   +1 more source

Cowpox with Severe Generalized Eruption, Finland

Emerging Infectious Diseases, 2003
Cowpox with a severe, generalized eruption was diagnosed in an atopic 4-year-old girl by electron microscopy, virus isolation, polymerase chain reaction, and immunoglobulin (Ig) M and low-avidity IgG antibodies.
Paula M. Pelkonen, Kyllikki Tarvainen, Arja Hynninen, Eva R.K. Kallio, Heikki Henttonen, Airi Palva, Antti Vaheri, Olli Vapalahti   +7 more
doaj   +1 more source