Results 91 to 100 of about 2,721 (157)

A Review of Compounds Exhibiting Anti-Orthopoxvirus Activity in Animal Models

, 2003
Several animal models using mice (most frequently), rabbits, or monkeys have been used to identify compounds active against orthopoxvirus infections.
Robert W Sidwell, Donald F Smee, Smee, Donald F, Sidwell, R. W., Sidwell, Robert W, Smee, Donald F.   +5 more
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What has been researched about monkeypox? a bibliometric analysis of an old zoonotic virus causing global concern

New Microbes and New Infections, 2022
Alfonso J. Rodríguez-Morales, Yeimer Ortiz-Martínez, D. Katterine Bonilla-Aldana   +2 more
doaj   +1 more source

Anti-Orthopoxvirus Activity of Amantadine and Rimantadine Derivatives—In Vitro Testing and Molecular Modeling

In 2022, the number of mpox cases spiked worldwide, leading to a surge in scientific research on members of the Orthopoxvirus genus and the discovery of new compounds exhibiting anti-orthopoxvirus activity.
Sergey G. Arkhipov, Ekaterina A. Akishina, Nikolay I. Bormotov, Olga I. Yarovaya, Olga A. Serova, Nariman F. Salakhutdinov, Sophia S. Borisevich, Edward M. Khamitov, Alexey Yu. Fedorov, Ivan A. Moskalev, Evgenij A. Dikusar, Larisa N. Shishkina, Vladimir. I. Potkin   +12 more
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Genomic characterization of monkeypox virus isolates (Orthopoxvirus monkeypox)

Virus majmunskih boginja (Orthopoxvirus monkeypox, Orthopoxvirus, Poxviridae MPXV) se smatrao endemskom vrstom zapadne i središnje Afrike sve do globalne epidemije mpox-a 2022. godine kada se proširio u neendemske regije Europe i SAD-a. Tijekom epidemije
Duvančić, Iva
core  

Immune Receptor Targeting by Orthopoxvirus MHC Class I-like Protein

, 2009
A successful immune response to an invading pathogen relies on recognition of the microbe, recruitment and trafficking of relevant immune cells, and proper activation and execution of their effector functions. A vast array of receptor-ligand interactions
Campbell, Jessica Ann
core   +1 more source

Orally available nucleoside analog UMM-766 provides protection in a murine model of orthopox disease

Microbiology Spectrum
Although smallpox has been eradicated, other orthopoxviruses continue to be a public health concern as exemplified by the ongoing Mpox (formerly monkeypox) global outbreak.
Rajini R. Mudhasani, Joseph W. Golden, Gregory C. Adam, Timothy J. Hartingh, Krishna P. Kota, David Ordonez, Corey R. Quackenbush, Julie P. Tran, Curtis Cline, Janice A. Williams, Xiankun Zeng, David B. Olsen, Linda A. Lieberman, Christopher Boyce, Anthony Ginnetti, J. Matthew Meinig, Rekha G. Panchal, Eric M. Mucker   +17 more
doaj   +1 more source

Species-specific differences in the structure of orthopoxvirus complement-binding protein

, 2001
Vaccinia virus complement-binding protein (VCP) is secreted from the cells infected with the virus and controls the complement activation reactions. This protein contains four short consensus repeats (SCR), typical of the protein family of complement ...
Shchelkunov, Sergei N, Elena A Uvarova, Uvarova, Elena A, Sergei N Shchelkunov   +3 more
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Orthopoxvirus [PDF]

, 2020
openaire   +1 more source

Orthopoxvirus i europeiska gnagare

Orthopoxviruses are a group of zoonotic pathogens that are able to infect a broad range of mammals, including many species of rodents. In European rodents, the most prevalent orthopoxvirus is the Cowpox virus, which is also known to be able to cause ...
Wiksten, Sofia
core  

Identification of neutralizing nanobodies protecting against poxvirus infection

Cell Discovery
An outbreak of mpox has triggered concerns regarding the adequacy of intervention strategies. Passive immunity conferred by neutralizing antibodies exhibits potential in the prophylaxis and treatment of orthopoxvirus infections.
Xuehua Yang, Li Guo, Huarui Duan, Miao Fan, Fengwen Xu, Xiaojing Chi, Shengnan Pan, Xiuying Liu, Xinhui Zhang, Peixiang Gao, Fangyuan Zhang, Xinyi Wang, Fei Guo, Jiwan Ge, Lili Ren, Wei Yang   +15 more
doaj   +1 more source