Results 71 to 80 of about 9,580 (245)

Discovery and Structural Characterization of a Highly Protective Neutralizing Antibody Targeting the Mpox Virus A35R Protein

MedComm, Volume 7, Issue 7, July 2026.
High‐affinity monoclonal antibodies (mAbs) targeting the MPXV EEV protein A35R were rapidly isolated using mRNA‐LNP vaccination and the Beacon single‐cell sorting Optofluidic platform, followed by functional profiling. One mAb, 17H1, potently neutralized authentic MPXV and conferred complete protection in vivo.
Shimeng Bai, Shuo Song, Xin Wang, Yuxin Xiao, Yun Long, Fenfang Wu, Fuxiang Wang, Zhongyi Fan, Jianqing Xu, Maozhou He, Hongzhou Lu   +10 more
wiley   +1 more source

Orthopoxvirus-specific antibodies wane to undetectable levels 1 year after MVA-BN vaccination of at-risk individuals, the Netherlands, 2022 to 2023

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
In response to the mpox outbreak in 2022 and 2023, widespread vaccination with modified vaccinia Ankara-Bavarian Nordic (MVA-BN, also known as JYNNEOS or Imvanex) was initiated.
L. V. van Leeuwen, M. Shamier, B. Verstrepen, Hannelore M Götz, K. Schmitz, Najlae Akhiyate, Koen Wijnans, S. Bogers, M.E. Van Royen, E. V. van Gorp, Marion P. G. Koopmans, R. D. de Vries, C. Geurtsvankessel, L. Zaeck   +13 more
semanticscholar   +1 more source

Genesis of Monkeypox

Journal of Pure and Applied Microbiology, 2022
A zoonotic orthopoxvirus known as monkeypox inadvertently produces a smallpox-like illness in humans but with far fewer fatalities. This infection is indigenous to most parts of the African continent, with outbreaks throughout the Western World linked to
Abdul Basit, Jasni Mohamad Zain, Hafiza Zoya Mojahid, Mushtaq Ali   +3 more
doaj   +1 more source

Efficacy and Safety of Messenger RNA Vaccines

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background and Aims The rapid development of mRNA vaccines has revolutionized infectious disease prevention and cancer immunotherapy. While their efficacy is well established, concerns about safety and immunopathological risks persist. This study aims to evaluate the immunogenicity, safety profiles, and design considerations of mRNA vaccines ...
Kesaobaka Batisani, David Chisompola
wiley   +1 more source

Recombinant orthopoxvirus primes colon cancer for checkpoint inhibitor and cross-primes T cells for anti-tumor and anti-viral immunity

Molecular Cancer Therapeutics, 2020
Although it is known that oncolytic viruses can inflame and recruit immune cells to otherwise immunosuppressed tumor microenvironments, the influence of the antiviral immune response on antitumor immunity is less clear across viral platforms and tumor ...
Sang-In Kim, Anthony K. Park, S. Chaurasiya, Seonah Kang, Jianming Lu, A. Yang, Venkatesh Sivanandam, Zhifang Zhang, Y. Woo, S. Priceman, Y. Fong, S. Warner   +11 more
semanticscholar   +1 more source

Orthopoxvirus Work Group update [PDF]

01-OPX-Sanchez-508 ...

core   +2 more sources

In Silico Design and Computational Characterization of Novel Chimeric Multiepitope Antigens for Mpox Serosurveillance: An Immunoinformatics Approach

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background and Aims The Monkeypox (Mpox) virus is a zoonotic Orthopoxvirus with a global outbreak that began in 2022, with more than 132,000 confirmed cases and 1500 deaths across over 128 countries. The pandemic preparedness pipeline emphasizes the importance of diagnostic surveillance of pathogens in at‐risk populations to monitor ...
Roland Ngwese Akwelle, Robert Adamu Shey, Mary Teke Efeti, Lekeayi Nelson Acha, Gordon Takop Nchanji, Yanick Aqua Stong Tangan, Joan Amban Chick, Ntang Emmaculate Yaah, Lahngong Methodius Shinyuy, Cabirou Mounchili Shintouo, Bernis Neneyoh Yengo, Abey Blessings Ayuk, Junior Ekunidi Engarimbi, Ketura Yaje Gwei, Brinate Teke Tebo, Derrick Neba Nebangwa, Beltine Muyer Tamnjong, Luc Vanhamme, Jacob Souopgui, Vincent P. K. Titanji, Stephen Mbigha Ghogomu   +20 more
wiley   +1 more source

Synergistic effect of two human-like monoclonal antibodies confers protection against orthopoxvirus infection

Nature Communications
The eradication of smallpox was officially declared by the WHO in 1980, leading to discontinuation of the vaccination campaign against the virus. Consequently, immunity against smallpox and related orthopoxviruses like Monkeypox virus gradually declines,
H. Tamir, Tal Noy-Porat, S. Melamed, Lilach Cherry-Mimran, Moria Barlev-Gross, R. Alcalay, Y. Yahalom-Ronen, H. Achdout, B. Politi, N. Erez, Shay Weiss, Ronit Rosenfeld, E. Epstein, O. Mazor, Efi Makdasi, N. Paran, T. Israely   +16 more
semanticscholar   +1 more source

Ophthalmic Features and Implications of Poxviruses: Lessons from Clinical and Basic Research

Microorganisms, 2022
Amidst the ongoing monkeypox outbreak, global awareness has been directed towards the prevention of viral transmission and case management, with the World Health Organization declaring the outbreak a public health emergency of international concern ...
Tolulope Fashina, Ye Huang, Joanne Thomas, Christopher D. Conrady, Steven Yeh   +4 more
doaj   +1 more source

Therapeutic Poxviruses Induce the Secretion of Immunostimulating and Anti‐Tumoral Extracellular Vesicles

Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.
Immune cells infected by therapeutic poxviruses release increased amounts of extracellular vesicles bearing viral proteins and therapeutic payloads. Such EVs have the ability to activate a CD8+ T‐cell mediated antitumoral immune response and decrease tumor growth.
Lucas Walther, Vincent Mittelheisser, Marie‐Christine Claudepierre, Louis Bochler, Magali Rompais, Jules Deforges, Nathalie Silvestre, Annabel Larnicol, Christine Carapito, Eric Quémeneur, Jacky G Goetz, Karola Rittner, Vincent Hyenne   +12 more
wiley   +1 more source