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Smallpox and Other Orthopoxvirus Diseases
VacciTUTOR, 2022Smallpox was a severe disease causing substantial mortality among populations over several thousand years. It is caused by an orthopoxvirus, the variola (= smallpox) virus. Smallpox is a febrile disease with a maculo-, papulo-, vesicular and finally pustular rash, the typical pox lesions, numerous complications and a fatality rate of approximately 30%.
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Pharmacological Review on Orthopoxvirus
Research Journal of Pharmacology and PharmacodynamicsMonkeypox is an emerging viral zoonotic disease caused by the monkeypox virus, which is particularly significant as it is endemic to Central and Western Africa. This disease is rare and manifests with a rash resembling that of smallpox. However, its transmission between individuals beyond close contact is limited, and the case fatality rates for ...
P. Devi Guna Sireesha +4 more
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Orthopoxvirus Purification for High Containment Laboratories
Purification of large viruses in a high containment laboratory can create unique challenges. Traditional purification methods for large viruses rely on equipment and techniques that are not ideal for high containment work. Poxvirus purification has long relied on the use of Genetron®, a reagent that is no longer available.Laura, Hughes +4 more
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Genus Orthopoxvirus: Monkeypox virus
2007Monkeypox virus is an orthopoxvirus that is genetically distinct from other members of the genus, including Variola virus, Vaccinia virus, Ectromelia virus, Camelpox virus, and Cowpox virus. It was first identified as the cause of a pox-like illness in captive monkeys in 1958.
Sandra Essbauer, Hermann Meyer
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Genus Orthopoxvirus: Cowpox virus
2007Cowpox virus (CPXV) is distinguished from other orthopoxvirus (OPV) species by producing cytoplasmic A-type inclusion bodies and flattened pocks with a hemorrhagic center on the chorioallantoic membrane. CPXV is endemic to Western Eurasia and naturally infects a broad range of host species including domestic animals, and zoo animals, as well as humans.
Sandra Essbauer, Hermann Meyer
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Orthopoxvirus Genome Sequencing, Assembly, and Analysis
Poxviruses have exceptionally large genomes compared to most other viruses, which represent unique challenges to sequencing and assembly due to complex features such as repeat elements and low complexity sequences. The 2022 global mpox outbreak led to an unprecedented level of poxvirus sequencing as public health and research institutions faced with ...Crystal M, Gigante +2 more
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Mécanismes d'échappement immunitaire des Orthopoxvirus Orthopoxvirus immune evasion mechanism
Médecine et Maladies Infectieuses, 2004F Messud-Petit, S Bertagnoli
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Genus Orthopoxvirus: Variola virus
2007Variola major virus caused the human disease smallpox; interpretations of the historic record indicate that the initial introduction of disease in a naive population had profound effects on its demographics. Smallpox was declared eradicated by the World Health Organization (WHO) in 1980.
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