Results 201 to 210 of about 9,580 (245)
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The preparation of orthopoxvirus DNA
Journal of Virological Methods, 1981Abstract A method is presented for the preparation of cross-linked, intact orthopoxvirus DNA from viral cores extracted from virus-infected cell cultures.
J, Esposito, R, Condit, J, Obijeski
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A Cross-Sectional Serosurvey of Anti-Orthopoxvirus Antibodies in Central and Western Africa [PDF]
Viruses, 2017 Since the eradication of smallpox and the subsequent discontinuation of the worldwide smallpox vaccination program, other Orthopoxviruses beside Variola virus have been increasingly representing a risk to human health.
Daniel Stern +2 more
exaly +2 more sources
European Journal of Medicinal Chemistry
The orthopoxvirus genus, particularly the monkeypox virus (MPXV), continues to pose a significant global public health threat. Therefore, the development of novel anti-orthopoxvirus agents remains an urgent priority.
Xixi Guo
exaly +2 more sources
The orthopoxvirus genus, particularly the monkeypox virus (MPXV), continues to pose a significant global public health threat. Therefore, the development of novel anti-orthopoxvirus agents remains an urgent priority.
Xixi Guo
exaly +2 more sources
ChemMedChem, 2022
In this work, a library of (+)‐camphor and (−)‐fenchone based N‐acylhydrazones, amides, and esters, including para‐substituted aromatic/hetaromatic/cyclohexane ring was synthesized, with potent orthopoxvirus inhibitors identified among them ...
A. Sokolova +15 more
semanticscholar +1 more source
In this work, a library of (+)‐camphor and (−)‐fenchone based N‐acylhydrazones, amides, and esters, including para‐substituted aromatic/hetaromatic/cyclohexane ring was synthesized, with potent orthopoxvirus inhibitors identified among them ...
A. Sokolova +15 more
semanticscholar +1 more source
1990
Genetic analysis of orthopoxviruses has contributed substantially to our understanding of the functional organization of the poxvirus genome, and individual mutants provide invaluable tools for future studies of poxvirus biology. Deletion and transposition mutants, localized primarily in the termini of the genome, may be particularly useful for ...
R C, Condit, E G, Niles
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Genetic analysis of orthopoxviruses has contributed substantially to our understanding of the functional organization of the poxvirus genome, and individual mutants provide invaluable tools for future studies of poxvirus biology. Deletion and transposition mutants, localized primarily in the termini of the genome, may be particularly useful for ...
R C, Condit, E G, Niles
openaire +2 more sources
Genome of Alaskapox Virus, a Novel Orthopoxvirus Isolated from Alaska
Viruses, 2019 Since the eradication of smallpox, there have been increases in poxvirus infections and the emergence of several novel poxviruses that can infect humans and domestic animals. In 2015, a novel poxvirus was isolated from a resident of Alaska.
Crystal M Gigante +2 more
exaly +2 more sources
2004
Biologic and antigenic properties are often useful for identifying and differentiating orthopoxviruses (OPV). However, polymerase chain reaction (PCR) amplification, with either restriction cleavage or sequencing of amplicons, has been gaining credibility as a more rapid, specific, sensitive, and often cost-saving technique for research and diagnostic ...
Hermann, Meyer +2 more
openaire +2 more sources
Biologic and antigenic properties are often useful for identifying and differentiating orthopoxviruses (OPV). However, polymerase chain reaction (PCR) amplification, with either restriction cleavage or sequencing of amplicons, has been gaining credibility as a more rapid, specific, sensitive, and often cost-saving technique for research and diagnostic ...
Hermann, Meyer +2 more
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The Lancet Microbe
BACKGROUND Cross-reactive immune memory responses to orthopoxviruses in humans remain poorly characterised despite their relevance for vaccine design and outbreak control.
Jameson Crandell +29 more
semanticscholar +1 more source
BACKGROUND Cross-reactive immune memory responses to orthopoxviruses in humans remain poorly characterised despite their relevance for vaccine design and outbreak control.
Jameson Crandell +29 more
semanticscholar +1 more source
The mechanism of cytoplasmic orthopoxvirus DNA replication
Cell, 1981Orthopoxvirus DNA replication occurs in the cytoplasm of infected cells within discrete foci designated as virosomes. We show that newly synthesized rabbit poxvirus (RPV) virosomal DNA consists predominantly of concatamers wherein unit length molecules are joined by fusion of two left (LL) or right (RR) ends, resulting in genomes aligned in alternating
R W, Moyer, R L, Graves
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npj Vaccines
Shortly after 2022, mpox again becomes a public health emergency of international concern as declared by the World Health Organization on August 14, 2024.
Fengwen Xu +23 more
semanticscholar +1 more source
Shortly after 2022, mpox again becomes a public health emergency of international concern as declared by the World Health Organization on August 14, 2024.
Fengwen Xu +23 more
semanticscholar +1 more source