Results 81 to 90 of about 89,050 (201)

Demographic and clinical features of pediatric patients with orthostatic intolerance and an abnormal head-up tilt table test; A retrospective descriptive study

Pediatrics and Neonatology, 2020
Background: Clinical presentation varies in children with Orthostatic Intolerance. This study aimed to evaluate the epidemiological and clinical characteristics of pediatric patients with orthostatic intolerance (OI) and positive head-up tilt test (HUTT).
Anand Gourishankar, Mathew D. Belton, S. Shahrukh Hashmi, Ian J. Butler, Jeremy E. Lankford, Mohammed T. Numan   +5 more
doaj   +1 more source

Exercise and physiological monitoring in isolated, confined and extreme environments and space analogues: A scoping review

Experimental Physiology, EarlyView.
Abstract This scoping review synthesized evidence on physical activity/exercise and physiological monitoring in isolated, confined and extreme (ICE) environments, with emphasis on Antarctic missions and space analogues. ICE exposures combine cold stress, confinement, disrupted light–dark cycles and psychosocial strain, which can challenge ...
Gustavo S. O. Lima, Kaline V. F. Dinis, Leonardo P. Silva, Nayanne B. Sousa, Maria Keiliane F. S. Silva, Danilo C. Talhari, Josélia S. Almeida, Michele M. Moraes, Rosa M. E. Arantes, Marcos A. Nascimento, Thiago T. Mendes   +10 more
wiley   +1 more source

Orthostatic intolerance predicts mild cognitive impairment: incidence of mild cognitive impairment and dementia from the Swedish general population cohort Good Aging in Skåne

, 2014
Sölve Elmståhl, Elisabet Widerström Division of Geriatric Medicine, Department of Health Sciences, Lund University, Skåne University Hospital, Malmö, Sweden Introduction: Contradictory results have been reported on the ...
Elmståhl S, Widerström E
core  

Cardiovascular Autonomic Neuropathy in Charcot–Marie–Tooth Disease: A Genotype‐Stratified Study of PMP22 Duplication and GJB1 Mutation Carriers

Journal of the Peripheral Nervous System, Volume 31, Issue 4, December 2026.
ABSTRACT Background and Aims Data on cardiovascular autonomic neuropathy (CAN) are sparse in Charcot–Marie–Tooth disease. We aimed to determine the prevalence of CAN in CMT1A and CMTX1 and its associations with neuropathy severity and heart rate variability (HRV), compared with age‐ and sex‐matched controls. Methods Thirty‐six CMT1A, 24 CMTX1 patients,
Kryštof Prášil, Veronika Potočková, Tomáš Nedělka, Alžběta Prášilová, Radim Mazanec   +4 more
wiley   +1 more source

Diabetic Autonomic Neuropathy and Impaired Inflammatory Reflex

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 6, November 2026.
The cholinergic anti‐inflammatory pathway under normal and diabetic conditions. In the normal state, vagal activation through nicotinic acetylcholine receptors helps regulate immune responses and suppress excessive inflammation. In diabetes, impaired autonomic function and dysregulated cholinergic signalling weaken this anti‐inflammatory pathway ...
Narges Dastmalchi, Mohammad Amin Doustvandi, Reza Rahbarghazi, Khalil Hajiasgharzadeh   +3 more
wiley   +1 more source

Orthostatic function and the cardiovascular response to early mobilization after breast cancer surgery

, 2010
Early postoperative mobilization is essential for an enhanced recovery, but it can be hindered by orthostatic intolerance, characterized by signs of cerebral hypoperfusion, such as dizziness, nausea, vomiting, and ultimately syncope.
Bundgaard-Nielsen, Morten, Gamborg Müller, Rasmus, Kehlet, H, M. Bundgaard-Nielsen, R.G. Müller, H. Kehlet   +5 more
core   +1 more source

Neurohumoral mechanisms associated with orthostasis: Reaffirmation of the significant contribution of the heart rate response

Frontiers in Physiology, 2014
The inability to compensate for acute central hypovolemia underlies the clinical development of orthostatic hypotension and instability (e.g., syncope). Although neuro-humoral control of both cardiac output and peripheral vascular resistance contributes ...
Victor A Convertino
doaj   +1 more source

Neurodegenerative Diseases: Epidemiology, Risk Factors, Classification, Pathophysiology, Clinical Features, Diagnosis, and Therapeutic Strategies

MedComm, Volume 7, Issue 11, November 2026.
Neurodegenerative diseases share convergent risk architectures and pathological mechanisms, yet diverge in selective vulnerability, clinical presentation, and therapeutic responsiveness. This review integrates cross‐disease epidemiology, pathophysiology, diagnosis, and treatment, highlighting the transition from symptomatic care toward biomarker‐guided
Zimeng He, Jingjing Zeng, Guoqing Wang, Yuxin Li, Feng Zhang   +4 more
wiley   +1 more source

Diabetic Polyneuropathy Patients Exhibit an Altered Skeletal Muscle Proteome Phenotype

PROTEOMICS – Clinical Applications, Volume 20, Issue 6, November 2026.
ABSTRACT Purpose Diabetic polyneuropathy (DPN) is a debilitating complication of diabetes that affects motor nerves and may impair skeletal muscle health. This study investigated skeletal muscle proteomic alterations associated with DPN compared with type 2 diabetes without DPN (T2D) and healthy controls (CON).
Frederik Forsberg Thybo, Karolina Snopek Khan, Jesper Emil Jakobsgaard, Henning Andersen, Kristian Vissing, Johan Palmfeldt   +5 more
wiley   +1 more source

Mechanisms of orthostatic intolerance during heat stress [PDF]

, 2016
Postprint, author's accepted manuscriptHeat stress profoundly and unanimously reduces orthostatic tolerance. This review aims to provide an overview of the numerous and multifactorial mechanisms by which this occurs in humans.
Schlader, Z. J., Crandall, C. G., Wilson, T. E.   +2 more
core   +1 more source