Results 111 to 120 of about 1,282,481 (350)

Rapid and sustained nuclear–cytoplasmic ERK oscillations induced by epidermal growth factor

Molecular Systems Biology, 2009
Although the ERK pathway has a central role in the response of cells to growth factors, its regulatory structure and dynamics are incompletely understood. To investigate ERK activation in real time, we expressed an ERK–GFP fusion protein in human mammary
Harish Shankaran, Danielle L Ippolito, William B Chrisler, Haluk Resat, Nikki Bollinger, Lee K Opresko, H Steven Wiley   +6 more
doaj   +1 more source

Modulation of Circadian Rhythm of DNA Synthesis in Tumor Cells by Inhibiting Platelet-Derived Growth Factor Signaling

Journal of Pharmacological Sciences, 2008
Circadian synchronization of cell proliferation is observed not only in normal healthy tissues but also in malignant solid tumors. However, the proliferation rhythm of tumor cells is often different from that of normal cells.
Hiroo Nakagawa, Satoru Koyanagi, Yukako Kuramoto, Akiko Yoshizumi, Naoya Matsunaga, Hiroshi Shimeno, Shinji Soeda, Shigehiro Ohdo   +7 more
doaj   +1 more source

An oscillating reaction network with an exact closed form solution in the time domain

BMC Bioinformatics, 2023
Background Oscillatory behavior is critical to many life sustaining processes such as cell cycles, circadian rhythms, and notch signaling. Important biological functions depend on the characteristics of these oscillations (hereafter, oscillation ...
Joseph Hellerstein
doaj   +1 more source

Oscillatory Ca2+ Signaling in the Isolated Caenorhabditis elegans Intestine

The Journal of General Physiology, 2005
Defecation in the nematode Caenorhabditis elegans is a readily observable ultradian behavioral rhythm that occurs once every 45–50 s and is mediated in part by posterior body wall muscle contraction (pBoc).
M. Espelt, A. Estevez, Xiaoyan Yin, K. Strange   +3 more
semanticscholar   +1 more source

Stochastic Binary Modeling of Cells in Continuous Time as an Alternative to Biochemical Reaction Equations

, 2011
We have developed a coarse-grained formulation for modeling the dynamic behavior of cells quantitatively, based on stochasticity and heterogeneity, rather than on biochemical reactions.
Akira, Shizuo, Kumagai, Yutaro, Standley, Daron M, Teraguchi, Shunsuke, Vandenbon, Alexis   +4 more
core   +1 more source

Plasma‐Treated Hydrogel for Combined RONS and Chemotherapy Delivery: A Proof‐of‐Concept In Ovo

Advanced Functional Materials, EarlyView.
This study explores plasma‐treated hydrogels (PTH) as a new way to deliver both reactive oxygen and nitrogen species and chemotherapy (Doxorubicin) directly to tumors. In ovo tests show effects after a single dose, especially in osteosarcoma tumors. Tumor weight decrease, and a resistance‐related protein is reduced.
Milica Živanić, Albert Espona‐Noguera, Angela Privat Maldonado, Patrik Matušů, Francesco Tampieri, Maria‐Pau Ginebra, Abraham Lin, Evelien Smits, Annemie Bogaerts, Cristina Canal   +9 more
wiley   +1 more source

Oscillatory calcium release and sustained store-operated oscillatory calcium signaling prevents differentiation of human oligodendrocyte progenitor cells

Scientific Reports, 2022
Endogenous remyelination in demyelinating diseases such as multiple sclerosis is contingent upon the successful differentiation of oligodendrocyte progenitor cells (OPCs).
Richard A. Seidman, Heba Khattab, Jessie J. Polanco, Jacqueline E. Broome, Fraser J. Sim   +4 more
doaj   +1 more source

Signaling between intracellular Ca2+ stores and depletion-activated Ca2+ channels generates [Ca2+]i oscillations in T lymphocytes

The Journal of General Physiology, 1994
Stimulation through the antigen receptor (TCR) of T lymphocytes triggers cytosolic calcium ([Ca2+]i) oscillations that are critically dependent on Ca2+ entry across the plasma membrane.
R. Dolmetsch, R. Lewis
semanticscholar   +1 more source

Soft and Stiff 3D Microstructures by Step‐Growth Photopolymerization Using a Single Photoresin and Multi‐Photon Laser Printing

Advanced Functional Materials, EarlyView.
An additive and initiator‐free photoresin based on a prepolymer decorated with photoreactive step‐growth units as crosslinkers allows for the fabrication of 3D microstructures with strongly disparate mechanical properties ranging from stiff to soft. Abstract Manufacturing three‐dimensional (3D) microstructures with multi‐material properties via two ...
Tugce Nur Eren, Jiajie Liang, Jonathan Ludwig Günter Schneider, Martin Wegener, Jens Bauer, Katharina Ehrmann, Florian Feist, Christopher Barner‐Kowollik   +7 more
wiley   +1 more source

Phase responses of oscillating components in a signaling pathway

Frontiers in Physiology, 2013
Signal transduction pathways control various events in mammalian cells such as growth, proliferation,differentiation, apoptosis, or migration in response to environmental stimuli.Because of their importance, the activity of signaling pathways is ...
Masaki eNomura, Mariko eOkada-Hatakeyama
doaj   +1 more source