PLCγ2 controls neutrophil-like cell sensitivity through calcium oscillation and gates chemoattractant concentration range for chemotaxis [PDF]
Frontiers in ImmunologyThe relationship between calcium oscillation and cell sensitivity is poorly understood. Calcium oscillation can occur spontaneously or be triggered upon receptor-ligand binding.
Xuehua Xu +3 more
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An agent-based model of metabolic signaling oscillations in Bacillus subtilis biofilms. [PDF]
PLoS Computational BiologyMicrobes of nearly every species can form biofilms, communities of cells bound together by a self-produced matrix. It is not understood how variation at the cellular level impacts putatively beneficial, colony-level behaviors, such as cell-to-cell ...
Obadiah J Mulder +4 more
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Bioengineering, 2023 Chemotaxis, regulated by oscillatory signals, drives critical processes in cancer metastasis. Crucial chemoattractant molecules in breast cancer, CXCL12 and EGF, drive the activation of ERK and Akt.
Kenneth K. Y. Ho +5 more
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Visualization of Notch Signaling Oscillation in Cells and Tissues [PDF]
, 2014 The Notch signaling effectors Hes1 and Hes7 exhibit oscillatory expression with a period of about 2-3 h during embryogenesis. Hes1 oscillation is important for proliferation and differentiation of neural stem cells, whereas Hes7 oscillation regulates periodic formation of somites.
Shimojo, Hiromi +2 more
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An excitable signal integrator couples to an idling cytoskeletal oscillator to drive cell migration [PDF]
Nature Cell Biology, 2013 It is generally believed that cytoskeletal activities drive random cell migration, whereas signal transduction events initiated by receptors regulate the cytoskeleton to guide cells. However, we find that the cytoskeletal network, involving SCAR/WAVE, Arp 2/3 and actin-binding proteins, is capable of generating only rapid oscillations and undulations ...
Chuan-Hsiang Huang +4 more
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Computational modeling of the interplay between cadherin-mediated cell adhesion and Wnt signaling pathway. [PDF]
PLoS ONE, 2014 Wnt signaling and cadherin-mediated adhesion have been implicated in both processes of embryonic development and the progression of carcinomas. Recent experimental studies revealed that Wnt signaling and cadherin-mediated cell adhesion have close ...
Jiawen Chen, Zhong-Ru Xie, Yinghao Wu
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Clofazimine inhibits human Kv1.3 potassium channel by perturbing calcium oscillation in T lymphocytes. [PDF]
PLoS ONE, 2008 The Kv1.3 potassium channel plays an essential role in effector memory T cells and has been implicated in several important autoimmune diseases including multiple sclerosis, psoriasis and type 1 diabetes.
Yunzhao R Ren +10 more
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Oscillation dynamics underlie functional switching of NF-κB for B-cell activation. [PDF]
, 2016 Transcription factor nuclear factor kappa B (NF-κB) shows cooperative switch-like activation followed by prolonged oscillatory nuclear translocation in response to extracellular stimuli.
Aihara, Kazuyuki +7 more
core +1 more source
Heat Oscillations Driven by the Embryonic Cell Cycle Reveal the Energetic Costs of Signaling [PDF]
Developmental Cell, 2019 All living systems function out of equilibrium and exchange energy in the form of heat with their environment. Thus, heat flow can inform on the energetic costs of cellular processes, which are largely unknown. Here, we have repurposed an isothermal calorimeter to measure heat flow between developing zebrafish embryos and the surrounding medium.
Jonathan, Rodenfels +2 more
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Cellular Architecture Regulates Collective Calcium Signaling and Cell Contractility.
PLoS Computational Biology, 2016 A key feature of multicellular systems is the ability of cells to function collectively in response to external stimuli. However, the mechanisms of intercellular cell signaling and their functional implications in diverse vascular structures are poorly ...
Jian Sun +4 more
doaj +1 more source