An excitable signal integrator couples to an idling cytoskeletal oscillator to drive cell migration [PDF]
Nature Cell Biology, 2013 It is generally believed that cytoskeletal activities drive random cell migration, whereas signal transduction events initiated by receptors regulate the cytoskeleton to guide cells. However, we find that the cytoskeletal network, involving SCAR/WAVE, Arp 2/3 and actin-binding proteins, is capable of generating only rapid oscillations and undulations ...
Chuan-Hsiang Huang +4 more
openaire +2 more sources
Clofazimine inhibits human Kv1.3 potassium channel by perturbing calcium oscillation in T lymphocytes. [PDF]
PLoS ONE, 2008 The Kv1.3 potassium channel plays an essential role in effector memory T cells and has been implicated in several important autoimmune diseases including multiple sclerosis, psoriasis and type 1 diabetes.
Yunzhao R Ren +10 more
doaj +1 more source
Heat Oscillations Driven by the Embryonic Cell Cycle Reveal the Energetic Costs of Signaling [PDF]
Developmental Cell, 2019 All living systems function out of equilibrium and exchange energy in the form of heat with their environment. Thus, heat flow can inform on the energetic costs of cellular processes, which are largely unknown. Here, we have repurposed an isothermal calorimeter to measure heat flow between developing zebrafish embryos and the surrounding medium.
Jonathan, Rodenfels +2 more
openaire +3 more sources
A transcriptomic taxonomy of Drosophila circadian neurons around the clock
eLife, 2021 Many different functions are regulated by circadian rhythms, including those orchestrated by discrete clock neurons within animal brains. To comprehensively characterize and assign cell identity to the 75 pairs of Drosophila circadian neurons, we ...
Dingbang Ma +6 more
doaj +1 more source
Signaling Pathways Underlying Muscarinic Receptor-induced [Ca2+] Oscillations in HEK293 Cells [PDF]
Journal of Biological Chemistry, 2001 We have investigated the signaling pathways underlying muscarinic receptor-induced calcium oscillations in human embryonic kidney (HEK293) cells. Activation of muscarinic receptors with a maximal concentration of carbachol (100 microm) induced a biphasic rise in cytoplasmic calcium ([Ca2+]i) comprised of release of Ca2+ from intracellular stores and ...
D, Luo +3 more
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Synchronization of oscillatory growth prepares fungal hyphae for fusion
eLife, 2023 Communication is crucial for organismic interactions, from bacteria, to fungi, to humans. Humans may use the visual sense to monitor the environment before starting acoustic interactions.
Valentin Wernet +5 more
doaj +1 more source
Protocol: optimised electrophyiological analysis of intact guard cells from arabidopsis [PDF]
, 2012 Genetic resources available for Arabidopsis thaliana make this species particularly attractive as a model for molecular genetic studies of guard cell homeostasis, transport and signalling, but this facility is not matched by accessible tools for ...
Adrian Hills +19 more
core +1 more source
Messages across time and space
eLife, 2020 Compartmentalized oscillations of second messengers affect global cellular signaling.
Sascha M Kuhn, André Nadler
doaj +1 more source
A multiscale hybrid model for pro-angiogenic calcium signals in a vascular endothelial cell [PDF]
, 2011 Cytosolic calcium machinery is one of the principal signaling mechanisms by which endothelial cells (ECs) respond to external stimuli during several biological processes, including vascular progression in both physiological and pathological conditions ...
Marco Scianna, Scianna, Marco
core +1 more source
Forty-five years of cGMP research in Dictyostelium:Understanding the regulation and function of the cGMP pathway for cell movement and chemotaxis [PDF]
, 2021 In Dictyostelium chemoattractants induce a fast cGMP response that mediates myosin filament formation in the rear of the cell. The major cGMP signaling pathway consists of a soluble guanylyl cyclase sGC, a cGMP-stimulated cGMP-specific phosphodiesterase ...
van Egmond, Wouter +7 more
core +1 more source