Results 41 to 50 of about 23,536 (303)
Frontiers in Computational Neuroscience, 2020 Neurons in many brain regions exhibit spontaneous, intrinsic rhythmic firing activity. This rhythmic firing activity may determine the way in which these neurons respond to extrinsic synaptic inputs. We hypothesized that neurons should be most responsive
Luuk van der Velden +2 more
doaj +1 more source
Neuronal oscillations enhance stimulus discrimination by ensuring action potential precision
, 2006 Although oscillations in membrane potential are a prominent feature of sensory, motor, and cognitive function, their precise role in signal processing remains elusive.
Margrie, Troy W +21 more
core +1 more source
Circadian oscillation of gibberellin signaling in Arabidopsis [PDF]
, 2011 Circadian clocks are endogenous timekeeping mechanisms that allow organisms to anticipate rhythmic, daily environmental changes. Temporal coordination of transcription results in a set of gene expression patterns with peak levels occurring ...
Arana, María Verónica +13 more
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, 2007 Adhesion molecules of the integrin beta1 family are thought to be involved in the malignant progression renal cell carcinoma (RCC). Still, it is not clear how they contribute to this process.
Jones, Jon +15 more
core +1 more source
Experimental Design for Stochastic Models of Nonlinear Signaling Pathways Using an Interval-Wise Linear Noise Approximation and State Estimation. [PDF]
PLoS ONE, 2016 BACKGROUND:Computational modeling is a key technique for analyzing models in systems biology. There are well established methods for the estimation of the kinetic parameters in models of ordinary differential equations (ODE).
Christoph Zimmer
doaj +1 more source
Autonomous Ca2+ Oscillations Reflect Oncogenic Signaling in B-ALL Cells
Blood, 2019 Background: Engagement of the B-cell receptor (BCR) results in Ca2+ flux and is linked to B-cell survival based on store-operated Ca2+ entry (SOCE), which is triggered by ORAI1 and stromal interaction molecule-1 (STIM1). While normal B-cells release Ca2+ only in response to external stimuli (e.g. BCR-engagement), we recently observed that transformed B-
Kohei Kume +3 more
openaire +1 more source
Circadian Oscillation of Sulfiredoxin in the Mitochondria
, 2015 Hydrogen peroxide (H2O2) released from mitochondria regulates various cell signaling pathways. Given that H2O2-eliminating enzymes such as peroxiredoxin III (PrxIII) are abundant in mitochondria, however, it has remained unknown how such release can ...
이서구, 길인섭, 이세경
core +1 more source
Digital image processing of optical density wave propagation in Dictyostelium discoideum and analysis of the effects of caffeine and ammonia [PDF]
, 1989 Waves of chemotactic movement during the early phase of aggregation in Dictyostelium discoideum were analyzed by digital image processing in a manner that immediately shows the following parameters: wave propagation velocity, period length, wave ...
Siegert, Florian, Weijer, Cornelis J.
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FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
iScience, 2020 Summary: Ca2+ oscillations that depend on inositol-1,4,5-trisphosphate (IP3) have been ascribed to biphasic Ca2+ regulation of the IP3 receptor (IP3R) or feedback mechanisms controlling IP3 levels in different cell types.
Paula J. Bartlett +3 more
doaj +1 more source