Results 101 to 110 of about 42,609 (234)

Thermotolerant D‐Hydantoinases for Efficient and Stereoselective Intermediate Synthesis of (R)‐3‐Isobutylglutaric Acid Monoamide, a Key Intermediate in Pregabalin Production

Microbial Biotechnology, Volume 19, Issue 3, March 2026.
We engineered thermo‐alkali‐stable D‐hydantoinases via mutagenesis (M63A/F65H/C317T) to resolve Pregabalin's challenging chiral splitting, achieving ee value > 97% for key intermediate (R)‐3‐isobutylglutaric acid monoamide (R‐IBM) synthesis under extreme conditions (pH 10, 70°C–80°C).
Jiujiuzi Zhang, Bin Zhi, Zhenyu Xie, Beibei Zhang, Ning Wang, Wanpeng Wang   +5 more
wiley   +1 more source

Influenza Virus Vaccine Efficacy Based On Conserved Sequence Alignment

, 2012
The rapid outbreak of bird flu challenges the outcome of effective vaccine for the upcoming years. The recent research established different norms to eliminate flu pandemics.
Jerald, Baby, Nair, T. R. Gopalakrishnan
core   +1 more source

Five years of monitoring for the emergence of oseltamivir resistance in patients with influenza A infections in the Influenza Resistance Information Study (IRIS) [PDF]

, 2018
Background and Objectives: The Influenza Resistance Information Study (IRIS) was initiated in 2008 to study the emergence of neuraminidase inhibitor (NAI) resistance and the clinical course of influenza in immunocompetent treated and untreated patients.
Aoki, Bloom, Bright, Centers for Disease Control and Prevention, Gaymard, Hauge, Hayden, Hurt, Hussain, Kim, Kiso, Kiso, Meijer, Meijer, Monto, Okomo-Adhiambo, Pozo, Rameix-Welti, Sheu, Stephenson, Tashiro, Tewawong, Vries, Wang, Wetherall, Whitley, World Health Organization (WHO), Yen   +27 more
core   +8 more sources

Symptoms Associated With Detection of Viral Versus Bacterial Pathogens in Outpatients With Lower Respiratory Infections

Influenza and Other Respiratory Viruses, Volume 20, Issue 3, March 2026.
ABSTRACT Purpose This study aims to identify symptoms that predict a high likelihood of viral infection, so these patients could be triaged for home care to avoid antibiotics. Methods We recruited adults presenting to US primary or urgent care sites with a chief complaint of cough and symptoms consistent with LRTI. Data collected included demographics,
Mark Ebell, Dan J. Merenstein, Bruce Barrett, Cassie Hulme, Sarah Walters, Caroline Hamer, Michelle Buhr   +6 more
wiley   +1 more source

Current and evolving approaches for improving the oral permeability of BCS Class III or analogous molecules [PDF]

, 2016
The Biopharmaceutics Classification System (BCS) classifies pharmaceutical compounds based on their aqueous solubility and intestinal permeability. The BCS Class III compounds are hydrophilic molecules (high aqueous solubility) with low permeability ...
Dave, Vivek S, Gupta, Deepak, Gupta, Sheeba Varghese, Nguyen, Phong, Yu, Monica   +4 more
core   +2 more sources

Influenza-associated mortality in hospital care: a retrospective cohort study of risk factors and impact of oseltamivir in an English teaching hospital, 2016 to 2017

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 2019
Background Evidence of an oseltamivir treatment effect on influenza A(H3N2) virus infections in hospitalised patients is incomplete. Aims This cohort study aimed to evaluate risk factors for death among PCR-confirmed hospitalised cases of seasonal ...
M. Reacher, B. Warne, L. Reeve, N. Verlander, N. Jones, K. Ranellou, Silvana Christou, Callum Wright, Saher Choudhry, M. Zambon, C. Sander, Hongyi Zhang, H. Jalal   +12 more
semanticscholar   +1 more source

Persistent Leukoencephalopathy Following H1N1 Infection Associated With a Novel MYRF Variant (p.Gly735Asp)

Annals of Clinical and Translational Neurology, Volume 13, Issue 2, Page 405-412, February 2026.
ABSTRACT Mutations in myelin regulatory factor (MYRF) are linked to demyelinating disorders. We report a 38‐year‐old male who developed acute symmetric leukoencephalopathy mimicking a stroke following an influenza A virus infection. While clinical symptoms markedly improved with corticosteroids, MRI revealed persistent white matter lesions, contrasting
Jinghan Hu, Leiyun Huang, Wan Zhu, Min Peng, Qiang Gong, Jing Qian   +5 more
wiley   +1 more source

Pandemic (H1N1) 2009 and Seasonal Influenza A (H1N1) Co-infection, New Zealand, 2009

Emerging Infectious Diseases, 2010
Co-infection with seasonal influenza A (H1N1) and pandemic (H1N1) 2009 could result in reassortant viruses that may acquire new characteristics of transmission, virulence, and oseltamivir susceptibility.
Matthew Peacey, Richard J. Hall, Stephanie Sonnberg, Mariette Ducatez, Shevaun Paine, Mackenzie Nicol, Jacqui C. Ralston, Don Bandaranayake, Virginia Hope, Richard J. Webby, Sue Huang   +10 more
doaj   +1 more source

Novel N-Substituted oseltamivir derivatives as potent influenza neuraminidase inhibitors: Design, synthesis, biological evaluation, ADME prediction and molecular docking studies.

European journal of medicinal chemistry, 2019
The discovery of novel potent neuraminidase (NA) inhibitors remains an attractive approach for treating infectious diseases caused by influenza. In this study, we describe the design and synthesis of novel N-substituted oseltamivir derivatives for ...
Jiqing Ye, Xiao Yang, Min Xu, P. Chan, Cong Ma   +4 more
semanticscholar   +1 more source

Rapid Recognition of Carfilzomib‐Induced Thrombotic Microangiopathy and Early Application of Eculizumab Successfully Rescued Two Relapsed Myeloma Patients

Chronic Diseases and Translational Medicine, Volume 12, Issue 1, Page 63-68, March 2026.
Zi Wang, Hua Zheng, Wei Wang, Xiaoxiao Shi, Yunpeng Wei, Chao Li, Junling Zhuang   +6 more
wiley   +1 more source