Results 111 to 120 of about 42,609 (234)

Newly recognized causes of acute lung injury: transfusion of blood products, severe acute respiratory syndrome, and avian influenza. [PDF]

, 2006
Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a clinical syndrome that has an ever-growing list of potential causes. The transfusion of blood products is often a life-saving therapy, but it can be associated with the development of ...
Looney, Mark R
core   +1 more source

Optimization of N-Substituted Oseltamivir Derivatives as Potent Inhibitors of Group-1 and -2 Influenza A Neuraminidases, Including a Drug-Resistant Variant.

Journal of Medicinal Chemistry, 2018
On the basis of our earlier discovery of N1-selective inhibitors, the 150-cavity of influenza virus neuraminidases (NAs) could be further exploited to yield more potent oseltamivir derivatives.
Jian Zhang, Vasanthanathan Poongavanam, Dongwei Kang, Chiara Bertagnin, Hua Lu, Xiujie Kong, Han Ju, Xueyi Lu, Ping Gao, Ye Tian, Haiyong Jia, Samuel Desta, Xiao Ding, Lin Sun, Zengjun Fang, Boshi Huang, Xuewu Liang, Ruifang Jia, Xiuli Ma, Wenfang Xu, N. A. Murugan, A. Loregian, Bing Huang, P. Zhan, Xinyong Liu   +24 more
semanticscholar   +1 more source

Point-of-care testing for disasters: needs assessment, strategic planning, and future design. [PDF]

, 2009
Objective evidence-based national surveys serve as a first step in identifying suitable point-of-care device designs, effective test clusters, and environmental operating conditions.
Bangs, Bulut, Cazacu, de la Hoz, Dighe, Diiulio, Ender, Farfel, Gerald J. Kost, Ginocchio, Grandjean, Grondhal, Hiransuthikul, Hurt, Ivers, Kazancioglu, Kost, Kost, Kost, Kost, Kost, Kristin N. Hale, Lam, Louie, Lupisan, Millie, MMWR, Nam K. Tran, Nicole L. Gentile, Nishiura, Pabbaraju, Qadri, Rajendran, Richard F. Louie, Schneider, Shaman, Shaman, Sinigalliano, T. Keith Brock, Tao, Thomas, Tyler K. Kitano, Uckay, Vernon, Vollaard   +44 more
core   +1 more source

Structure-Based Optimization of N-Substituted Oseltamivir Derivatives as Potent Anti-Influenza A Virus Agents with Significantly Improved Potency against Oseltamivir-Resistant N1-H274Y Variant.

Journal of Medicinal Chemistry, 2018
Due to the emergence of highly pathogenic and oseltamivir-resistant influenza viruses, there is an urgent need to develop new anti-influenza agents. Herein, five subseries of oseltamivir derivatives were designed and synthesized to improve their activity
Jian Zhang, N. A. Murugan, Ye Tian, Chiara Bertagnin, Zengjun Fang, Dongwei Kang, Xiujie Kong, Haiyong Jia, Zhuosen Sun, Ruifang Jia, Ping Gao, Vasanthanathan Poongavanam, A. Loregian, Wenfang Xu, Xiuli Ma, Xiao Ding, Bing Huang, P. Zhan, Xinyong Liu   +18 more
semanticscholar   +1 more source

A Pilot Study of Value of Information Analysis to Support Research Recommendations for the National Institute for Health and Clinical Excellence [PDF]

Background - This project developed as a result of the activities of the Research Teams at the Centre for Health Economics, University of York, and ScHARR at the University of Sheffield in the methods and application of decision analysis and value of ...
Alan Wailoo, Christopher McCabe, Karl Claxton, Laura Ginnelly, Paul Tappenden, Simon Eggington, Susan Griffin, Zoe Philips   +7 more
core  

Influenza A(H1N1)pdm09 Resistance and Cross-Decreased Susceptibility to Oseltamivir and Zanamivir Antiviral Drugs [PDF]

, 2015
Neuraminidase inhibitors (NAIs) oseltamivir and zanamivir are currently the only effective antiviral drugs available worldwide for the management of influenza.
Almeida-Santos, MM, Correia, V, Gíria, M, Rebelo-de-Andrade, H, Santos, L   +4 more
core   +1 more source

Trends in Anti-Influenza Drug Prescription and Adverse Drug Reaction Reporting After the Lifting of Oseltamivir Prescribing Restrictions in Pediatric Outpatients: An Ecological Study Using the MDV Analyzer® And the Japanese Adverse Drug Event Report Database

Drugs - Real World Outcomes
Background Abnormal behavior after oseltamivir administration has been reported in the media; in 2007, the package insert for oseltamivir phosphate was revised to restrict its administration to individuals aged over 10 years.
Misaki Tokunaga, Daisuke Kikuchi, Aoi Noda, Sachiko Oikawa, Makoto Shiozawa, Hiroaki Hino, Ryosuke Miura, Kensuke Usui, Taku Obara, Kouji Okada   +9 more
doaj   +1 more source

Efficacy and safety of intravenous peramivir versus oral oseltamivir in the treatment of influenza in children: A meta-analysis

Journal of Clinical Virology Plus
Objective: To investigate the efficacy and safety of intravenous peramivir compared to oral oseltamivir for pediatric influenza by a method of meta-analysis.
Jie Yuan, Shuhua An, Zhongfu Zhang
doaj   +1 more source

Influenza and Other Respiratory Virus Weekly Activity Report, March 28, 2009, Week 12 [PDF]

, 2009
Weekly report of the Iowa Influenza Surveillance Network produced by the Iowa Department of Public ...

core  

Development of oseltamivir and zanamivir resistance in influenza A(H1N1)pdm09 virus, Denmark, 2014

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 2017
Antiviral treatment of immunocompromised patients with prolonged influenza virus infection can lead to multidrug resistance. This study reveals the selection of antiviral resistance mutations in influenza A(H1N1)pdm09 virus in an immunocompromised ...
R. Trebbien, S. Pedersen, K. Vorborg, K. Franck, T. Fischer   +4 more
semanticscholar   +1 more source