DETECTION OF ANTIMICROBIAL COMPOUNDS FROM THERMOPHILIC ACTINOMYCETES USING ONE STRAIN MANY COMPOUNDS (OSMAC) APPROACH [PDF]
BioLink, 2022 Actinomycetes are a group of filamentous bacteria with high biosynthetic potential that can produce secondary metabolites. Actinomycetes are known to produce secondary metabolites which are potential as antimicrobial, antitumor, and others. Actinomycetes
Endah Wati Zahroh +2 more
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Bivariate One Strain Many Compounds Designs Expand the Secondary Metabolite Production Space in Corallococcus coralloides [PDF]
Microorganisms, 2023 The scarcely investigated myxobacterium Corallococcus coralloides holds a large genome containing many uncharacterized biosynthetic gene clusters (BGCs) that potentially encode the synthesis of entirely new natural products. Despite its promising genomic
Anton Lindig +4 more
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Studies on Secondary Metabolites of Streptomyces gossypiisoli TRM 44567 under the Guidance of OSMAC Strategy [PDF]
Polish Journal of MicrobiologyStreptomycetes synthesize a wide variety of biologically active compounds, such as antimicrobials, enzyme blockers, insecticides, and weed killers, offering the potential for use in farming as agents for enhancing plant health and defense.
CHEN YI HUANG +6 more
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Rapid Discovery of Substances with Anticancer Potential from Marine Fungi Based on a One Strain–Many Compounds Strategy and UPLC-QTOF-MS [PDF]
Marine Drugs, 2023 The secondary metabolites of marine fungi with rich chemical diversity and biological activity are an important and exciting target for natural product research. This study aimed to investigate the fungal community in Quanzhou Bay, Fujian, and identified
Yu-Ting Wu +9 more
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Evaluation of Apple Root-Associated Endophytic Streptomyces pulveraceus Strain ES16 by an OSMAC-Assisted Metabolomics Approach [PDF]
Frontiers in Sustainable Food Systems, 2021 The One Strain Many Compounds approach (OSMAC) is a powerful and comprehensive method that enables the chemo-diversity evaluation of microorganisms. This is achieved by variations of physicochemical cultivation parameters and by providing biotic and ...
Reyhaneh Armin +4 more
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OSMAC-Based Discovery and Biosynthetic Gene Clusters Analysis of Secondary Metabolites from Marine-Derived Streptomyces globisporus SCSIO LCY30 [PDF]
Marine Drugs, 2023 The one strain many compounds (OSMAC) strategy is an effective method for activating silent gene clusters by cultivating microorganisms under various conditions.
Yanqing Li +7 more
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An OSMAC Strategy for the Production of Antimicrobial Compounds by the Amazonian Fungi Talaromyces pinophilus CCM-UEA-F0414 and Penicillium paxilli CCM-UEA-F0591 [PDF]
AntibioticsBackground/Objectives: The emergence of antimicrobial resistance represents a critical global health threat, requiring the discovery of novel bioactive compounds.
Cleudiane Pereira de Andrade +9 more
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OSMAC guided bioprospecting of Atlantic sponges reveals novel bacterial species and evidence for the antimicrobial thiazole alkaloid agrochelin II [PDF]
Applied and Environmental MicrobiologyThe deep sea remains a major reservoir of underexplored microbial diversity and biosynthetic novelty. Here, we describe three bacterial species isolated from Atlantic sponges, including Stappia quadratibracata sp. nov., Bacillus crepusculi sp.
Sam E. Williams +14 more
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Genome mining and OSMAC strategies unveil diverse secondary metabolites from the endophytic fungus Diaporthe kyushuensis ZMU-48-1 with antifungal activity [PDF]
Frontiers in MicrobiologyFungal-derived bioactive natural products are a crucial resource for drug discovery; however, under standard laboratory cultivation conditions, fungi predominantly yield known and repetitively isolated metabolites.
Jiaqi Zheng +5 more
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Investigation of Antimicrobial Compounds Produced by Endolichenic Fungi in Different Culture Media [PDF]
The Plant Pathology JournalContinuous use of synthetic fungicides has led to explosive emergence of fungicide-resistant microbes. Therefore, there are urgent needs for environmentally friendly antimicrobial agents with novel modes of action.
Jaycee Augusto G. Paguirigan +4 more
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