OSMaC strategies to discover new natural products
, 2023 As cianobactérias são microrganismos fotossintéticos capazes de produzir uma larga gama de produtos secundários, desde toxinas a outros compostos com aplicações biotecnológicas e farmacêuticas reconhecidas. Recentes avanços na Genómica e Bioinformática têm vindo a demonstrar que os genomas das cianobactérias codificam para mais conjuntos de genes ...
openaire +1 more source
Sorbicillasins A–B and Scirpyrone K from a Deep-Sea-Derived Fungus, Phialocephala sp. FL30r
Marine Drugs, 2018 Two new nitrogen-containing sorbicillinoids named sorbicillasins A and B (1 and 2) and a new 3,4,6-trisubstituted α-pyrone derivative, scirpyrone K (3), together with two known biosynthetically related polyketides (4–5), were isolated from ...
Zhenzhen Zhang +6 more
doaj +1 more source
Antibiotic Discovery from the Abyss [PDF]
, 2020 It is essential that we discover and develop new antibiotics to overcome the problems associated with antibiotic resistance and find treatments for bacteria that don’t respond well to currently available treatment options.
Stennett, Henry
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Induced secondary metabolites from the endophytic fungus Aspergillus versicolor through bacterial co-culture and OSMAC approaches [PDF]
, 2018 LBK
Abdelwahab, Miada F. +9 more
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Complexity of fungal polyketide biosynthesis and function
Molecular Microbiology, Volume 121, Issue 1, Page 18-25, January 2024.Fungal secondary metabolites are the basis of many pharmaceuticals. Fungal genome analyses revealed a huge, but yet unexplored potential for more and new secondary metabolites. The review focuses on polyketides, their biosynthesis, their natural functions, and strategies for new discoveries of compounds and functions.
Maria C. Stroe +3 more
wiley +1 more source
GC- and UHPLC-MS Profiles as a Tool to Valorizate the Red Alga Asparagopsis armata [PDF]
, 2020 Conference Report XVI International Symposium on Marine Natural Products | XI European Conference on Marine Natural Products, 1-5 September 2019, Peniche, Portugal.Asparagopsis armata is considered a biological invader and this red alga is in the last ...
Lesenfants, Marie L. +3 more
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Marine Drugs, 2019 Terrosamycins A (1) and B (2), two polycyclic polyether natural products, were purified from the fermentation broth of Streptomyces sp. RKND004 isolated from Prince Edward Island sediment.
Amanda Sproule +6 more
doaj +1 more source
Cryptic Secondary Metabolites from the Sponge-Associated Fungus Aspergillus ochraceus
Marine Drugs, 2019 The fungus Aspergillus ochraceus was isolated from the Mediterranean sponge Agelas oroides. The initial fermentation of the fungus on solid rice medium yielded 16 known compounds (4⁻19).
Marian Frank +7 more
doaj +1 more source
Aplospojaveedins A-C, unusual sulfur-containing alkaloids produced by the endophytic fungus Aplosporella javeedii using OSMAC strategy. [PDF]
Front MicrobiolThree sulfur-containing alkaloids aplospojaveedins A–C (1–3) with a hitherto undescribed carbon skeleton comprising octahy-dronaphthalene, α, β-unsaturated lactam and glycine-cysteine moieties were isolated from Aplosporella javeedii. Their structures were elucidated by 1D and 2D NMR spectroscopy, HR-MS, X-ray diffraction analysis, DFT-NMR and TDDFT ...
Gao Y +16 more
europepmc +5 more sources
Identification of Bioactive Molecules from Arctic Marine Arthrobacter Isolates [PDF]
, 2021 In this study, five isolated Arctic marine bacteria of the genus Arthrobacter were cultivated under different temperatures and growth media. Employing the “One Strain-Many Compounds” (OSMAC) approach, in an attempt to produce novel and interesting ...
Trosten, Ella
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