Using a 'one strain-many compounds' approach to screen a collection of diverse fungi from Aotearoa New Zealand for antibacterial activity against <i>Escherichia coli</i>. [PDF]
Microbiology (Reading)van de Pas S +8 more
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O-methyltransferase CbzMT catalyzes iterative 3,4-dimethylations for carbazomycin biosynthesis. [PDF]
Eng MicrobiolLin B +7 more
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Genome mining of Streptomyces bambergiensis AC-800 unravels the biosynthetic gene cluster for inhibitors of prolyl hydroxylase fibrostatins. [PDF]
Sci RepGuerrero Garzón JF +6 more
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OSMAC and Co-Culture Approaches for Diversifying Secondary Metabolites from Endophytic Fungi
, 2020 openaire +1 more source
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Six new sesquiterpenes, fusarchlamols A-F (1, 2, 4-7); one new natural product of sesquiterpenoid, methyltricinonoate (3); and ten known compounds were found from Fusarium sp. cultured in two different media by the one strain many compounds strategy. The compounds (1, 2, and 4-11) were isolated from Fusarium sp.
Jing, Sun +7 more
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OSMAC: Optimizing Subgraph Matching Algorithms with Community Structure
2019 IEEE 35th International Conference on Data Engineering (ICDE), 2019Subgraph has gained increasing attention as it is an important query type on graphs. The efficiency of existing subgraph matching algorithms becomes unsatisfactory since graphs gradually get larger and more complex. This paper proposes an optimization method named OSMAC to accelerate subgraph matching algorithms with the community structure of data ...
Yunkai Lou, Chaokun Wang
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OSMAC approach leads to new fusarielin metabolites from Fusarium tricinctum
The Journal of Antibiotics, 2017Using the OSMAC (One Strain MAny Compounds) approach, the fungal endophyte Fusarium tricinctum was cultivated on fruit and vegetable juice-supplemented solid rice media. This led to an up to 80-fold increase in the accumulation of the new natural product fusarielin J (1), as well as to the induction of two new natural products fusarielin K (2) and ...
Catalina F Pérez, Hemphill +6 more
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Cytotoxic cytochalasans from Aspergillus flavipes PJ03-11 by OSMAC method
Tetrahedron Letters, 2018Abstract Two new cytochalasans flavichalasine N (1), flavichalasine O (2), together with six known cytochalasans (3–8), were isolated from Aspergillus flavipes PJ03-11 through the application of OSMAC (one strain many compounds) strategy. Flavichalasine O (2) represented the first example of cytochalasans possessing a nitrogen-oxygen heterocycle at ...
Yingying Si +9 more
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Abstract Fungi are an extraordinary source of bioactive metabolites especially because their metabolic profile can be modulated according to the conditions under which they are grown, a strategy known as OSMAC. Aspergillus sydowii has been showing to be a fungal species with a series of interesting biosynthetic pathways, but production of ...
Gesiane da Silva Lima +5 more
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OSMAC Strategy: A promising way to explore microbial cyclic peptides
European Journal of Medicinal ChemistryMicrobial secondary metabolites are pivotal for the development of novel drugs. However, conventional culture techniques, have left a vast array of unexpressed biosynthetic gene clusters (BGCs) in microorganisms, hindering the discovery of metabolites with distinct structural features and diverse biological functions.
Yu Zhang +4 more
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