Results 161 to 170 of about 1,906 (172)

Induction of ambuic acid derivatives by the endophytic fungus Pestalotiopsis lespedezae through an OSMAC approach

Tetrahedron, 2021
Abstract Ten new ambuic acid derivatives, pestallic acids H–Q including one new iodinated natural product along with two known compounds, ambuic acid and ambuic acid 18-acetate, were obtained through fermentation of the endophytic fungus Pestalotiopsis lespedezae on solid rice medium with 3.5% NaI. Pestallic acids H–Q were undetectable in cultures of
Xiaoqin Yu, Ying Gao, Marian Frank, Attila Mándi, Tibor Kurtán, Werner E.G. Müller, Rainer Kalscheuer, Zhiyong Guo, Kun Zou, Zhen Liu, Peter Proksch   +10 more
openaire   +2 more sources

Discovery of andrastones from the deep-sea-derived Penicillium allii-sativi MCCC 3A00580 by OSMAC strategy

Bioorganic Chemistry, 2021
Andrastones are unusual 6,6,6,5-tetracyclic meroterpenoids that are rarely found in nature. Previously, three andrastones were obtained from the rice static fermentation extract of the deep-sea-derived fungus Penicillium allii-sativi MCCC 3A00580. Inspired by one strain many compounds (OSMAC) approach, the oat static fermentation on P. allii-sativi was
Chun-Lan, Xie, Qingmei, Liu, Zhi-Hui, He, Ying-Bao, Gai, Zheng-Biao, Zou, Zong-Ze, Shao, Guang-Ming, Liu, Hai-Feng, Chen, Xian-Wen, Yang   +8 more
openaire   +2 more sources

Mycobolome of Phialomyces Macrosporus Across OSMAC‐Based Assorted Culture Media

Chemistry & Biodiversity
AbstractThe fungus Phialomyces macrosporus was cultured using the One Strain Many Compounds (OSMAC) strategies to evaluate its metabolome. Variations in the nutrient culture media, culture regime, and cultivation parameters can significantly influence fungal extract quantity and chemical diversity.
Vitória Evelyn Teles de Jesus, Yasmin Alvarenga, Elisangela F. Boffo, Regina Geris   +3 more
openaire   +2 more sources

Tricycloalternarenes F–H: Three new mixed terpenoids produced by an endolichenic fungus Ulocladium sp. using OSMAC method

Fitoterapia, 2013
Three new mixed terpenoids, tricycloalternarenes (TCAs) F-H (1-3), together with ten known tricycloalternarenes (4-13), were isolated from the Czapek's culture of an endophytic fungus Ulocladium sp. Their structures were identified by extensive spectroscopic experiments (NMR and MS) and comparison with literature data.
Quan-Xin, Wang, Li, Bao, Xiao-Li, Yang, Hui, Guo, Biao, Ren, Liang-Dong, Guo, Fu-Hang, Song, Wen-Zhao, Wang, Hong-Wei, Liu, Li-Xin, Zhang   +9 more
openaire   +2 more sources

Novel bioactive molecules from Lentzea violacea strain AS 08 using one strain-many compounds (OSMAC) approach

Bioorganic & Medicinal Chemistry Letters, 2017
A new eudesmane sesquiterpenoid (1), and a new homologue of virginiae butanolide E (2) along with butyl isobutyl phthalate (3) were isolated from, actinomycete-Lentzea violacea strain AS08 isolated from north western Himalayas by stressing on modified one strain-many compounds (OSMAC) method.
Aehtesham, Hussain, Muzafar A, Rather, Mohd S, Dar, Mushtaq A, Aga, Nisar, Ahmad, Aabid, Manzoor, Arem, Qayum, Aiyatullah, Shah, Saleem, Mushtaq, Zahoor, Ahmad, Qazi P, Hassan   +10 more
openaire   +2 more sources

Studium změn antimikrobiální aktivity houby Ganoderma adspersum pomocí kultivační strategie OSMAC

2023
Ganoderma adspersum is a white rot fungus that degrades lignocellulose in nature. However, it has also been proven to have many biological activities, including antioxidant, antitumor and anti-inflammatory. This study is focused on monitoring the antimicrobial activity of G.
openaire   +1 more source

Discovery of a Hybrid Molecule with Phytotoxic Activity by Genome Mining, Heterologous Expression, and OSMAC Strategy

Journal of Agricultural and Food Chemistry
Genome mining in association with the OSMAC (one strain, many compounds) approach provides a feasible strategy to extend the chemical diversity and novelty of natural products. In this study, we identified the biosynthetic gene cluster (BGC) of restricticin, a promising antifungal agent featuring a reactive primary amine, from the fungus Aspergillus ...
Yubo Lu, Yanpeng Li, Min Dou, Dong Liu, Wenhan Lin, Aili Fan   +5 more
openaire   +2 more sources

Microbial Coculture and OSMAC Approach as Strategies to Induce Cryptic Fungal Biogenetic Gene Clusters

2017
This chapter provides an overview of successful examples that highlight the power of the one strain many compounds (OSMAC) approach or of microbial cocultivation for an elicitation of bioactive fungal natural products that resulted either in an enhanced accumulation of constitutively present compounds, and/or in an accumulation of new natural compounds
openaire   +1 more source

[OSMAC (one strain many compounds) approach in the research of microbial metabolites--a review].

Wei sheng wu xue bao = Acta microbiologica Sinica, 2010
Microbial secondary metabolites have a wide range of biological activities due to their structural diversity and have been proved a major source for drug lead compounds. However,the traditional method of a single culture restricts the metabolic pathways of microorganisms and as a result many metabolites cannot be formed.
Hongjuan, Wei, Zhenjian, Lin, Dehai, Li, Qianqun, Gu, Tianjiao, Zhu   +4 more
openaire   +1 more source

Study on the Secondary Metabolites of Neosartorya fischeri via the OSMAC Method

Advances in Microbiology, 2021
openaire   +1 more source