Cryptic Metabolites from Marine-Derived Microorganisms Using OSMAC and Epigenetic Approaches [PDF]
Marine Drugs, 2022 Marine microorganisms have proven to be a source of new natural products with a wide spectrum of biological activities relevant in different industrial sectors.
Cristina Pinedo-Rivilla +2 more
doaj +4 more sources
Extending the “One Strain Many Compounds” (OSMAC) Principle to Marine Microorganisms [PDF]
Marine Drugs, 2018 Genomic data often highlights an inconsistency between the number of gene clusters identified using bioinformatic approaches as potentially producing secondary metabolites and the actual number of chemically characterized secondary metabolites produced ...
Stefano Romano +3 more
doaj +4 more sources
Frontiers in Microbiology, 2023 IntroductionAlkaloidal natural products are attractive for their broad spectrum of pharmaceutical bioactivities. In the present work, the highly productive saline soil derived fungus, Penicillium raistrichii, was subjected to the strategy of OSMAC (one ...
Meijia Zhong +4 more
doaj +3 more sources
Unveiling the Substrate-Dependent Dynamics of Mycotoxin Production in Fusarium verticillioides Using an OSMAC-Metabolomics Approach. [PDF]
Chem BiodiversAbstract Fusarium verticillioides is a prevalent plant pathogenic fungus known to produce harmful mycotoxins, including fumonisins and emerging toxins. This study aimed to investigate the influence of substrate on the temporal patterns of mycotoxin biosynthesis by F.
Groppi E +4 more
europepmc +4 more sources
Metabolomic Strategies to Improve Chemical Information from OSMAC Studies of Endophytic Fungi
Metabolites, 2023 Metabolomics strategies are important tools to get holistic chemical information from a system, but they are scarcely applied to endophytic fungi to understand their chemical profiles of biosynthesized metabolites. Here Penicillium sp. was cultured using
Fernanda Motta Ribeiro da Silva +4 more
doaj +3 more sources
Journal of Fungi, 2023 Different fungal species belonging to the Colletotrichum genus cause anthracnose disease in a range of major crops, resulting in huge economic losses worldwide. Typical symptoms include dark, sunken lesions on leaves, stems, or fruits. Colletotrichum spp.
Pierluigi Reveglia +5 more
doaj +4 more sources
Exploring Structural Diversity of Microbe Secondary Metabolites Using OSMAC Strategy: A Literature Review [PDF]
Frontiers in Microbiology, 2019 Microbial secondary metabolites (MSMs) have played and continue to play a highly significant role in the drug discovery and development process. Genetically, MSM chemical structures are biologically synthesized by microbial gene clusters.
Rui Pan +4 more
doaj +3 more sources
A systems approach using OSMAC, Log P and NMR fingerprinting: An approach to novelty
Synthetic and Systems Biotechnology, 2017 The growing number of sequenced microbial genomes has revealed a remarkably large number of secondary metabolite biosynthetic clusters for which the compounds are still unknown.
Miaomiao Liu +5 more
doaj +4 more sources
Cytosporin Derivatives from Arctic-Derived Fungus Eutypella sp. D-1 via the OSMAC Approach
Marine Drugs, 2023 A chemical investigation of the Arctic-derived fungus Eutypella sp. D-1 based on the OSMAC (one strain many compounds) approach resulted in the isolation of five cytosporin polyketides (compounds 1–3 and 11–12) from rice medium and eight cytosporins ...
Hao-Bing Yu +7 more
doaj +3 more sources
OSMAC-Driven Discovery of Six New Alkaloids from the Cold-Seep-Derived Fungus Talaromyces amestolkiae HDN21-0307 [PDF]
Marine DrugsSix new alkaloid compounds, including two rare aromatic nitrile compounds talaronitriles A–B (1–2), a novel oxime-functionalized azadiphilone analogue talarooxime A (3), a new phenylhydrazone alkaloid talarohydrazone E (4), and two new dipeptide ...
Xinsheng Huang +8 more
doaj +2 more sources