Results 31 to 40 of about 1,906 (172)
Activation of the Dimer of 3, 4-dimethylphenol Production From Marine Streptomyces sp. FJNU027 Under Oligotrophic Condition. [PDF]
MicrobiologyopenThis study assessed the potential for secondary metabolites production of marine Streptomyces sp. FJNU027 under various media. It was found the FJNU027 strain produced a differential compound in oligotrophic medium. The pure compound was obtained through mass fermentation, extraction and isolation, and identified as the dimer of 3, 4‐dimethylphenol ...
Wang F +7 more
europepmc +2 more sources
Optimal Surrogate-Assisted Sampling for Cost-Efficient Validation of Electronic Health Record Outcomes. [PDF]
Stat MedABSTRACT Electronic Health Record (EHR) databases are an increasingly valuable resource for observational studies. However, misclassification of EHR‐derived outcomes due to imperfect phenotyping leads to bias, inflated type I error, and reduced power in risk‐factor association studies. On the other hand, manual chart review to validate outcomes is both
Marks-Anglin A +4 more
europepmc +2 more sources
Impact of growth conditions on the abundance and diversity of cultivable bacteria recovered from <i>Pheronema carpenteri</i> and investigation of their antimicrobial potential. [PDF]
FEMS MicrobesConway J +5 more
europepmc +3 more sources
Triaging of Culture Conditions for Enhanced Secondary Metabolite Diversity from Different Bacteria
Biomolecules, 2021 Over the past decade, the one strain many compounds (OSMAC) approach has been established for the activation of biosynthetic gene clusters (BGCs), which mainly encode the enzymes of secondary metabolite (SM) biosynthesis pathways.
Jenny Schwarz +3 more
doaj +1 more source
Molecules, 2021 Apple Replant Disease (ARD) is a significant problem in apple orchards that causes root tissue damage, stunted plant growth, and decline in fruit quality, size, and overall yield.
Reyhaneh Armin +4 more
doaj +1 more source
Molecules, 2021 Three endophytic fungi isolated from Moquiniastrum polymorphum (Less.) G. Sancho (Asteraceae) were cultivated using the one strain many compounds (OSMAC) strategy to evaluate the production of griseofulvin derivatives.
Victor F. Farinella +5 more
doaj +1 more source
Angewandte Chemie, Volume 134, Issue 23, June 7, 2022., 2022 Light and glutamic acid induced E. gracilis to produce euglenatides with antifungal and anticancer activity. Euglenatides were also detected in E. sanguinea and E. mutabilis. They resemble the nemamides isolated from C. elegans, inhibited both producing species, and represent uniquely convergent assembly‐line biosynthesis between unicellular organisms ...
Mohammed Aldholmi +15 more
wiley +2 more sources
Allelopathic Polyketides from an Endolichenic Fungus Myxotrichum SP. by Using OSMAC Strategy [PDF]
Scientific Reports, 2016 AbstractThree new polyketides myxotritones A-C (2–4), together with a new natural product 7,8-dihydro-7R,8S-dihydroxy-3,7-dimethyl-2-benzopyran-6-one (1) were obtained from the endolichenic fungus Myxotrichum sp. by using OMSAC (One Strain, Many Compounds) method.
Chao Yuan +7 more
openaire +2 more sources
Induction of New Lactam Derivatives From the Endophytic Fungus Aplosporella javeedii Through an OSMAC Approach [PDF]
Frontiers in Microbiology, 2020 Fermentation of the endophytic fungus Aplosporella javeedii on solid rice medium in presence of either 3.5% NaNO3 or 3.5% monosodium glutamate caused a significant change of the fungal metabolite pattern compared to fungal controls grown only on rice. Chemical investigation of the former fungal extracts yielded 11 new lactam derivatives, aplosporellins
Ying Gao +10 more
openaire +4 more sources
Marine Drugs, 2021 “One strain many compounds” (OSMAC) based approaches have been widely used in the search for bioactive compounds. Introducing stress factors like nutrient limitation, UV-light or cocultivation with competing organisms has successfully been used in ...
Renate Døving Osvik +5 more
doaj +1 more source