Results 61 to 70 of about 1,906 (172)

Influence of OSMAC-Based Cultivation in Metabolome and Anticancer Activity of Fungi Associated with the Brown Alga Fucus vesiculosus

Marine Drugs, 2019
The fungi associated with marine algae are prolific sources of metabolites with high chemical diversity and bioactivity. In this study, we investigated culture-dependent fungal communities associated with the Baltic seaweed Fucus vesiculosus. Altogether,
Bicheng Fan, Delphine Parrot, Martina Blümel, Antje Labes, Deniz Tasdemir   +4 more
doaj   +1 more source

Rethinking the Idea of Ability: Convergence of People, Paradigms and Prototypes [PDF]

, 2023
This research article explores the evolving concept of ability in the context of contemporary society, focusing on the convergence of diverse elements such as individuals, paradigms, and prototypes. The traditional understanding of ability has often been
Maruthi, T. R., Sadat, Kavitha L, Basira
core  

Induction of New Aromatic Polyketides from the Marine Actinobacterium Streptomyces griseorubiginosus through an OSMAC Approach

Marine Drugs, 2023
Using the OSMAC (One Strain Many Compounds) approach, the actinobacterium Streptomyces griseorubiginosus, derived from an unidentified cnidarian collected from a reef near Pointe de Bellevue in Réunion Island (France), was subjected to cultivation under diverse conditions. This endeavour yielded the isolation of a repertoire of 23 secondary metabolites
Víctor Rodríguez Martín-Aragón, Francisco Romero Millán, Cristina Cuadrado, Antonio Hernández Daranas, Antonio Fernández Medarde, José M. Sánchez López   +5 more
openaire   +3 more sources

Genetics of Polyketide Metabolism in Aspergillus nidulans [PDF]

, 2012
metabolite
Adams, Bailey, Bergmann, Bergmann, Birkinshaw, Blount, Brechbühler, Brown, Bullock, Chang, Chang, Chen, Chen, Chiang, Chung, Couch, Crawford, Ehrlich, Ehrlich, Fujita, Fukuyama, Fukuyama, Halo, Halo, Hatsuda, Hatsuda, Henry, Holker, Howard, Kelkar, Kelkar, Keller, Keller, Krappmann, Li, Liu, Marshall, Mayorga, McDonald, McInnes, Meyers, Neelakantan, Nekam, O’Hara, Pontecorvo, Sanchez, Scott, Silva, Simpson, Simpson, Sims, Szewczyk, Terao, Trail, Watanabe, Watanabe, Xu, Yabe, Yabe, Yadav, Yu, Yu, Yuill   +62 more
core   +4 more sources

Fungal Endophytes as Efficient Sources of Plant-Derived Bioactive Compounds and Their Prospective Applications in Natural Product Drug Discovery: Insights, Avenues, and Challenges

Microorganisms, 2021
Fungal endophytes are well-established sources of biologically active natural compounds with many producing pharmacologically valuable specific plant-derived products.
Archana Singh, Dheeraj K. Singh, Ravindra N. Kharwar, James F. White, Surendra K. Gond   +4 more
doaj   +1 more source

The Bristol Sponge Microbiome Collection:A unique repository of deep-sea microorganisms and associated natural products [PDF]

, 2020
The deep ocean is the largest habitat for life on Earth, though the microorganisms that occupy this unique environmental niche remain largely unexplored.
Back, Catherine, Challand, Martin R, Curnow, Paul, Essex-Lopresti, Angela, Hendry, Katharine, Ojeda Gomez, Jorge, Race, Paul R, Spencer, James, Stennett, Henry L, Tiwari, Kavita, Williams, Sam, Willis, Chris L   +11 more
core   +2 more sources

Steroids Produced by Endophytic Fungus Lasiodiplodia Theobromae From Aglaia Argentea Blume and Their Cytotoxic Activity Against Hela Cervical Cancer Cell Lines [PDF]

, 2023
Three steroids, ergosterol (1), ergosterol peroxide (2) and stigmasterol (3) have been isolated from endophytic fungus, Lasiodiplodia theobromae derived from the root of Aglaia argentea Blume.
Azhari, Azmi, Harneti, Desi, Mulyani, Yeni, Purbaya, Sari, Sari, Aprilia Permata, Supratman, Unang, Wulandari, Asri Peni   +6 more
core   +2 more sources

Three new polyketides from Ascotricha sp. ZJ-M-5 by the OSMAC strategy

Journal of Asian Natural Products Research, 2018
Three new compounds, ascotrichols A-B (1–2) and ascotrichrone A (3), along with two known isocoumarin derivatives (4–5), were isolated from the solid culture of a sea mud-derived fungus, Ascotricha sp. ZJ-M-5 on rice media. The structures were elucidated by extensive spectroscopic analyses, including 1D and 2D NMR data, and the absolute configurations ...
Ya-Jing Dong, Guo-Mei Hou, Bin Lin, Dan-Yi Li, Zhan-Lin Li   +4 more
openaire   +2 more sources

Production of antibacterial compounds by a Steely hybrid polyketide synthase in Dictyostelium

FEBS Open Bio, Volume 16, Issue 1, Page 68-78, January 2026.
By selecting appropriate production species under optimised culture conditions, new chlorinated dibenzofuran compounds, which previously could not be analysed in sufficient quantities, were identified from cellular slime mould fruiting bodies. The strong antibacterial activity exhibited by these compounds suggests a link to the ecological function of ...
Tomoaki R. Yamashita, Toyonobu Usuki, Robert R. Kay, Tamao Saito   +3 more
wiley   +1 more source

Genome Mining and Metabolic Profiling Reveal Cytotoxic Cyclodipeptides in Streptomyces hygrospinosus var. Beijingensis

Antibiotics, 2022
Two new cyclodipeptide (CDP) derivatives (1–2) and another seven known cyclodipeptides (3–9) were isolated from Streptomyces 26D9-414 by the genome mining approach combined with genetic dereplication and the “one strain many compounds” (OSMAC) strategy ...
Dashan Zhang, Junbo Wang, Yongjian Qiao, Baixin Lin, Zixin Deng, Lingxin Kong, Delin You   +6 more
doaj   +1 more source