Results 71 to 80 of about 1,906 (172)

Natural product libraries: Assembly, maintenance, and screening [PDF]

, 2014
This review discusses successful strategies and potential pitfalls to assembling a natural product-based library suitable for high-throughput screening. Specific extraction methods for plants, microorganisms, and marine invertebrates are detailed, along ...
Butler, Mark S., Cooper, Matthew A., Fontaine, Frank   +2 more
core   +1 more source

Cytotoxic potential of Nephthea sp.-derived actinomycetes supported by metabolomics analysis [PDF]

, 2022
Soft corals and associated microorganisms are known to produce leads for anticancer drugs. Keeping this in mind, Nephthea sp.; a Red Sea soft coral was investigated for the first time using the OSMAC approach. Two isolates, Streptomyces sp.
Abdelhafez, Omnia Hesham, Abdelmohsen, Usama Ramadan, Fahim, John Refaat, Ngwa, Che J., Pradel, Gabriele, Rateb, Mostafa E.   +5 more
core   +2 more sources

Highlighting the biotechnological potential of deep oceanic crust fungi through the prism of their antimicrobial activity [PDF]

, 2021
© The Author(s), 2021. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Quemener, M., Dayras, M., Frotté, N., Debaets, S., Le Meur, C., Barbier, G., Edgcomb, V., Mehiri, M., &
Barbier, Georges, Burgaud, Gaëtan, Dayras, Marie, Debaets, Stella, Edgcomb, Virginia P., Frotté, Nicolas, Le Meur, Christophe, Mehiri, Mohamed, Quemener, Maxence   +8 more
core   +2 more sources

Co‐cultivation and Medium Optimization: A Strategy for Discovering Fungal‐derived Protease Inhibitors

Chemistry &Biodiversity, Volume 22, Issue 12, December 2025.
ABSTRACT The fungi Fusarium guttiforme and Phytophthora palmivora were cultivated in four different media (Potato Dextrose Agar, Czapek, rice, and ISP2) and co‐cultured to stimulate fungal interactions and enhance secondary metabolite production. Promising extracts were fractionated, yielding compounds such as the iron complex of fusaric acid (1 ...
Vitor de Souza Mazucato, Ludmilla Tonani, Marcia Regina von Zeska Kress, Adriano Defini Andricopulo, Gisele Barbosa, Renata Krogh, Leonardo Luiz Gomes Ferreira, Paulo Cezar Vieira   +7 more
wiley   +1 more source

Non‐Heme Iron Enzymes Catalyze Heterobicyclic and Spirocyclic Isoquinolone Core Formation in Piperazine Alkaloid Biosynthesis

Angewandte Chemie, Volume 136, Issue 20, May 13, 2024.
The biosynthesis of newly identified alkaloids featuring unique heterobicyclic and spirocyclic isoquinolone skeletons, arizonamides and arizolidines, has been characterized. Notably, the non‐heme iron enzyme ParG demonstrated catalytic versatility in multiple oxidative reactions, including cyclization and ring reconstruction.
Mai‐Truc Pham, Feng‐Ling Yang, I‐Chen Liu, Po‐Huang Liang, Hsiao‐Ching Lin   +4 more
wiley   +2 more sources

Amazonian Cyanobacteria as a Source of Bioactive Compounds With Antimicrobial and Cytotoxic Properties

Chemistry &Biodiversity, Volume 22, Issue 12, December 2025.
ABSTRACT Cyanobacteria are photosynthetic microorganisms known for producing diverse bioactive compounds. This study explores the bioactivity of extracts and fractions from Amazonian cyanobacteria and their pigment and phenolic compound production. A fraction from Synechococcus sp. CACIAM 05 showed cytotoxicity against hCMEC/D3 and MG‐63 cells.
Samuel Cavalcante do Amaral, Luciana Pereira Xavier, Mariana Reis, Rhuana V. Médice, Janaína Morone, Raquel Silva, João Morais, Vitor Vasconcelos, Agenor Valadares Santos   +8 more
wiley   +1 more source

Exploring deep-sea Actinomycetota chemical diversity by using the OSMAC approach

Frontiers in Marine Science
The constant need to search for new drugs is a major driver for the discovery of new molecules of pharmaceutical interest. Natural products (NPs) of microbial origin have been recognized for their therapeutic properties, with Actinomycetota being one of ...
Sofia Correia, Sofia Correia, Inês Ribeiro, Andreia Braga-Henriques, Andreia Braga-Henriques, Andreia Braga-Henriques, Andreia Braga-Henriques, Andreia Braga-Henriques, Pedro N. Leão, Ralph Urbatzka, Maria F. Carvalho, Maria F. Carvalho   +11 more
doaj   +1 more source

Integration of soft skills in the teaching of technical courses: an exploratory study of a private university / Hairuzila Idrus [PDF]

, 2013
Institutions of higher education have been pressed by the industry practitioners to produce quality graduates who are ready to compete in the competitive job market locally and globally.
Idrus, Hairuzila
core  

Marine Fungi from the Sponge Grantia compressa: Biodiversity, Chemodiversity, and Biotechnological Potential

Marine Drugs, 2019
The emergence of antibiotic resistance and viruses with high epidemic potential made unexplored marine environments an appealing target source for new metabolites. Marine fungi represent one of the most suitable sources for the discovery of new compounds.
Elena Bovio, Laura Garzoli, Anna Poli, Anna Luganini, Pietro Villa, Rosario Musumeci, Grace P. McCormack, Clementina E. Cocuzza, Giorgio Gribaudo, Mohamed Mehiri, Giovanna C. Varese   +10 more
doaj   +1 more source

Microtiter Plate Cultivation Systems Enable Chemically Diverse Metabolic Footprints During Bacterial Natural Product Discovery

Biotechnology and Bioengineering, Volume 122, Issue 8, Page 2021-2036, August 2025.
The utilization of microtiter plate cultivation systems in the discovery of natural products expands the secondary metabolic footprint. Microtiter plate cultivation systems, in particular the 48 well flower plate, facilitate the parallelization of bacterial cultivation and offer a greater degree of comparability to stirred tank bioreactors in ...
Anton Lindig, Georg Hubmann, Stephan Lütz   +2 more
wiley   +1 more source