Results 81 to 90 of about 1,906 (172)

Product strategies for packaged software : an exploratory analysis of the spreadsheet market [PDF]

open access: yes, 1993
Thesis (M.S.)--Massachusetts Institute of Technology, Sloan School of Management, 1993.Includes bibliographical references (p. 101-113).by Donna D. Mayo and Daniel A.
Mayo, Donna D. (Donna Dorothy)   +1 more
core  

OSMAC strategy and LC–MS profiling reveal metabolic diversity and bioactivities of Xylaria thienhirunae SWUF17-44.1

open access: yesAnnals of Microbiology
Background Xylariaceous fungi represent a promising source of secondary metabolites with diverse biological functions. However, their metabolic capacity often remains underestimated under conventional cultivation.
Pitchapa Thongsuwan   +5 more
doaj   +1 more source

Induction of metabolic variability of the endophytic fungus Xylaria sp. by OSMAC approach and experimental design

open access: yesArchives of Microbiology, 2021
This work has as the main focus, to analyze the behavior of physic-chemical variations from the fungus Xylaria sp., through the OSMAC (One Strain, Many Compounds) approach as an efficient way of obtaining new compounds. To perform such inductions and to explore the variability of the metabolic network of this microorganism, a factorial design was ...
Rafael Vieira   +4 more
openaire   +3 more sources

Desvendando o potencial bioativo de bactérias marinhas [PDF]

open access: yes, 2021
Besides a primary metabolism, living organisms possess a secondary metabolism which allows for the production of secondary metabolites that, normally, are not fundamental to the organism’s growth and survival.
João, Susana Afonso
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Use of microwave technology in transdermal drug delivery / Nor Khaizan Anuar [PDF]

open access: yes, 2013
The project focused on the use of microwave in controlling drug release from film matrix and modifying skin barrier for transdermal drug delivery. With reference to controlledrelease application, the effects of microwave on drug release properties of ...
Anuar, Nor Khaizan
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Optimization of Secondary Metabolite Production in the Sponge Associated Bacterium Roseivirga sp. PAP.19 Using the OSMAC Approach

open access: yesJurnal Ilmiah Perikanan dan Kelautan
Graphical Abstract  Highlight Research • Compounds produced by Roseivirga PAP.19 bacteria have potential as antimicrobials. • The OSMAC approach was used successfully to activate BGCs of Roseivirga PAP.19.
Andin Syamsi Pradani   +5 more
doaj   +1 more source

Combining OSMAC, metabolomic and genomic methods for the production and annotation of halogenated azaphilones and ilicicolins in termite symbiotic fungi

open access: yesScientific Reports, 2022
We gathered a collection of termite mutualistic strains from French Guiana to explore the metabolites of symbiotic microorganisms. Molecular networks reconstructed from a metabolomic analysis using LC–ESI–MS/MS methodology led us to identify two families
Téo Hebra   +3 more
doaj   +1 more source

Integrated genome and metabolome mining unveiled structure and biosynthesis of novel lipopeptides from a deep‐sea Rhodococcus

open access: yesMicrobial Biotechnology, Volume 17, Issue 11, November 2024.
Combining genome mining and mass spectrometry‐based metabolomics disclosed the deep‐sea Rhodococcus sp. I2R as a source of two families of novel lipopeptide biosurfactants with antiproliferative activity against human A375 melanoma cells. Abstract Microbial biosurfactants have garnered significant interest from industry due to their lower toxicity ...
Costanza Ragozzino   +8 more
wiley   +1 more source

Harnessing Gram‐negative bacteria for novel anti‐Gram‐negative antibiotics

open access: yesMicrobial Biotechnology, Volume 17, Issue 11, November 2024.
In this mini‐review, we highlight prominent examples of novel anti‐Gram negative natural products produced by isolated Gram‐negative bacteria that are currently in pre‐clinical development. Furthermore, we will provide insights into the considerations and strategies behind the discovery of these agents and their putative applications.
Joy Birkelbach   +3 more
wiley   +1 more source

Solanum nigrum: A review study with anti-cancer and antitumor perspective [PDF]

open access: yes, 2016
Solanum nigrum or locally just black nightshade is a species in the Solanum genus, native to Eurasia and introduced in the Americas, Australasia, and South Africa.
Miraj, S.
core  

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