Results 91 to 100 of about 1,517 (182)
Harnessing Gram‐negative bacteria for novel anti‐Gram‐negative antibiotics
Microbial Biotechnology, Volume 17, Issue 11, November 2024.In this mini‐review, we highlight prominent examples of novel anti‐Gram negative natural products produced by isolated Gram‐negative bacteria that are currently in pre‐clinical development. Furthermore, we will provide insights into the considerations and strategies behind the discovery of these agents and their putative applications.
Joy Birkelbach +3 more
wiley +1 more source
GC- and UHPLC-MS Profiles as a Tool to Valorizate the Red Alga Asparagopsis armata [PDF]
, 2020 Conference Report XVI International Symposium on Marine Natural Products | XI European Conference on Marine Natural Products, 1-5 September 2019, Peniche, Portugal.Asparagopsis armata is considered a biological invader and this red alga is in the last ...
Lesenfants, Marie L. +3 more
core +1 more source
Comptes Rendus. ChimieMarine fungi have been found in all habitats and are able to adapt to their environmental niche conditions. In this study, a combination of liquid chromatography coupled to high-resolution mass spectrometry (LC-HRMS) and gas chromatography coupled to ...
Le, Van-Tuyen +8 more
doaj +1 more source
Identification of Bioactive Molecules from Arctic Marine Arthrobacter Isolates [PDF]
, 2021 In this study, five isolated Arctic marine bacteria of the genus Arthrobacter were cultivated under different temperatures and growth media. Employing the “One Strain-Many Compounds” (OSMAC) approach, in an attempt to produce novel and interesting ...
Trosten, Ella
core
Complexity of fungal polyketide biosynthesis and function
Molecular Microbiology, Volume 121, Issue 1, Page 18-25, January 2024.Fungal secondary metabolites are the basis of many pharmaceuticals. Fungal genome analyses revealed a huge, but yet unexplored potential for more and new secondary metabolites. The review focuses on polyketides, their biosynthesis, their natural functions, and strategies for new discoveries of compounds and functions.
Maria C. Stroe +3 more
wiley +1 more source
Implementation of the novel high-throughput Fungal Isolation one step Device method FIND and secondary metabolite extraction from the isolate Heydenia cf. alpina [PDF]
, 2021 Fungi are an important source of bioactive metabolites. The cultivation of source organisms is a crucial step in natural product isolation. With standard isolation methods for fungi it is difficult to isolate rare und underexamined fungi from ...
Libor, Benjamin
core
Microbial Biotechnology, Volume 17, Issue 8, August 2024.
Miriam Rodríguez +5 more
wiley +1 more source
Molecular Networking Analysis and Antibacterial Potential of Ethyl Acetate Extracts of Sinomicrobium sp. PAP.21 using OSMAC Method [PDF]
Challenges in drug discovery include biosynthetic gene clusters which remain silent under standard laboratory culture conditions. On the other hand, the rediscovery of the known compounds is inevitable.
Harwoko, Harwoko +2 more
core +2 more sources
Malaysian Journal of Microbiology, 2019 Aims: A rare marine-derived actinomycete, Plantactinospora sp. KBS50, has been identified as a potential source of bioactive secondary metabolites compounds. The present study aimed to evaluate the secondary metabolites biosynthetic capability of strain KBS50 using the One Strain Many Compound (OSMAC) fermentation strategy.
Juboi, H. +3 more
openaire +2 more sources
Eutypellaolides A–J, Sesquiterpene diversity expansion of the polar fungus Eutypella sp. D-1
Frontiers in MicrobiologyEight new 12,8-eudesmanolide sesquiterpenes, eutypellaolides A–H (1–8), and two new eudesmane-type sesquiterpenes, eutypellaolides I–J (9–10), along with four known 12,8-eudesmanolide compounds 11–14, were isolated from the culture extract of the polar ...
Zhe Ning +10 more
doaj +1 more source