Results 21 to 30 of about 1,517 (182)

OSMAC-Driven Discovery of Six New Alkaloids from the Cold-Seep-Derived Fungus Talaromyces amestolkiae HDN21-0307 [PDF]

Marine Drugs
Six new alkaloid compounds, including two rare aromatic nitrile compounds talaronitriles A–B (1–2), a novel oxime-functionalized azadiphilone analogue talarooxime A (3), a new phenylhydrazone alkaloid talarohydrazone E (4), and two new dipeptide ...
Xinsheng Huang, Jiajin Wu, Luning Zhou, Zhengjie Wang, Qian Che, Liangzhen Chen, Wenxue Wang, Tianjiao Zhu, Dehai Li   +8 more
doaj   +2 more sources

New acorane-sesequiterpenes and anti-retinoblastoma constituents from the marine algicolous fungus Trichoderma harzianum NTU2180 guided by molecular networking strategy [PDF]

Botanical Studies
Background Trichoderma species, known as biocontrol agents against plant diseases, contain diverse compounds, especially terpenoids, with various bioactivities.
Andrea Gu, Fan-Li Lin, Chung-Kuang Lu, Tz-Wei Yeh, Yih-Fung Chen, Ho-Cheng Wu, Tzong-Huei Lee   +6 more
doaj   +2 more sources

Discovery of new eremophilanes from the marine-derived fungus Emericellopsis maritima BC17 by culture conditions changes: evaluation of cytotoxic and antimicrobial activities [PDF]

Frontiers in Marine Science
In our previous studies, the marine-derived fungus Emericellopsis maritima BC17 was found to produce new eremophilane-type sesquiterpenoids on solid media. In order to explore its potential to produce more metabolites, E. maritima BC17 was subjected to a
Jorge R. Virués-Segovia, Jorge R. Virués-Segovia, Cristina Pinedo, Cristina Pinedo, David Zorrilla, Jesús Sánchez-Márquez, Pilar Sánchez, María C. Ramos, Mercedes de la Cruz, Josefina Aleu, Josefina Aleu, Rosa Durán-Patrón, Rosa Durán-Patrón   +12 more
doaj   +3 more sources

Induced secondary metabolites from the endophytic fungus Aspergillus versicolor through bacterial co-culture and OSMAC approaches [PDF]

Tetrahedron Letters, 2018
LBK
Abdelwahab, Miada F., Daletos, Georgios, Ebrahim, Weaam, Fouad, Mostafa A., Kamel, Mohamed S., Kurtán, Tibor, Liu, Zhen, Mándi, Attila, Müller, Werner E. G., Proksch, Peter   +9 more
core   +2 more sources

Investigation of Antimicrobial Compounds Produced by Endolichenic Fungi in Different Culture Media [PDF]

The Plant Pathology Journal
Continuous use of synthetic fungicides has led to explosive emergence of fungicide-resistant microbes. Therefore, there are urgent needs for environmentally friendly antimicrobial agents with novel modes of action.
Jaycee Augusto G. Paguirigan, Eunah Jeong, Kyo Bin Kang, Jae-Seoun Hur, Wonyong Kim   +4 more
doaj   +2 more sources

Combining OSMAC Approach and Untargeted Metabolomics for the Identification of New Glycolipids with Potent Antiviral Activity Produced by a Marine Rhodococcus. [PDF]

Int J Mol Sci, 2021
Natural products of microbial origin have inspired most of the commercial pharmaceuticals, especially those from Actinobacteria. However, the redundancy of molecules in the discovery process represents a serious issue. The untargeted approach, One Strain Many Compounds (OSMAC), is one of the most promising strategies to induce the expression of silent ...
Palma Esposito F, Giugliano R, Della Sala G, Vitale GA, Buonocore C, Ausuri J, Galasso C, Coppola D, Franci G, Galdiero M, de Pascale D.   +10 more
europepmc   +4 more sources

New Polyketide Congeners with Antibacterial Activities from an Endophytic Fungus Stemphylium globuliferum 17035 (China General Microbiological Culture Collection Center No. 40666) [PDF]

Journal of Fungi
Four new polyketides, heterocornol Y (1), stemphyindan (2), pestalospirane C (3), and stemphyspyrane (4), along with five known ones (5–9) were isolated from the endophytic fungus Stemphylium globuliferum 17035 (SG17035) based on the One Strain Many ...
Yingying Li, Guoliang Zhu, Jing Wang, Junjie Yu, Ke Ye, Cuiping Xing, Biao Ren, Bin Zhu, Simin Chen, Lijun Lai, Yue Li, Tom Hsiang, Lixin Zhang, Xueting Liu, Jingyu Zhang   +14 more
doaj   +2 more sources

Activation of the Dimer of 3, 4-dimethylphenol Production From Marine Streptomyces sp. FJNU027 Under Oligotrophic Condition. [PDF]

Microbiologyopen
This study assessed the potential for secondary metabolites production of marine Streptomyces sp. FJNU027 under various media. It was found the FJNU027 strain produced a differential compound in oligotrophic medium. The pure compound was obtained through mass fermentation, extraction and isolation, and identified as the dimer of 3, 4‐dimethylphenol ...
Wang F, Yuan H, Bai C, Li H, Xu L, Yu L, Luo L, Zheng Y.   +7 more
europepmc   +2 more sources

Optimal Surrogate-Assisted Sampling for Cost-Efficient Validation of Electronic Health Record Outcomes. [PDF]

Stat Med
ABSTRACT Electronic Health Record (EHR) databases are an increasingly valuable resource for observational studies. However, misclassification of EHR‐derived outcomes due to imperfect phenotyping leads to bias, inflated type I error, and reduced power in risk‐factor association studies. On the other hand, manual chart review to validate outcomes is both
Marks-Anglin A, Chen J, Luo C, Hubbard R, Chen Y.   +4 more
europepmc   +2 more sources

Triaging of Culture Conditions for Enhanced Secondary Metabolite Diversity from Different Bacteria

Biomolecules, 2021
Over the past decade, the one strain many compounds (OSMAC) approach has been established for the activation of biosynthetic gene clusters (BGCs), which mainly encode the enzymes of secondary metabolite (SM) biosynthesis pathways.
Jenny Schwarz, Georg Hubmann, Katrin Rosenthal, Stephan Lütz   +3 more
doaj   +1 more source