Results 61 to 70 of about 1,517 (182)

The Bristol Sponge Microbiome Collection:A unique repository of deep-sea microorganisms and associated natural products [PDF]

, 2020
The deep ocean is the largest habitat for life on Earth, though the microorganisms that occupy this unique environmental niche remain largely unexplored.
Back, Catherine, Challand, Martin R, Curnow, Paul, Essex-Lopresti, Angela, Hendry, Katharine, Ojeda Gomez, Jorge, Race, Paul R, Spencer, James, Stennett, Henry L, Tiwari, Kavita, Williams, Sam, Willis, Chris L   +11 more
core   +2 more sources

Cytotoxic potential of Nephthea sp.-derived actinomycetes supported by metabolomics analysis [PDF]

, 2022
Soft corals and associated microorganisms are known to produce leads for anticancer drugs. Keeping this in mind, Nephthea sp.; a Red Sea soft coral was investigated for the first time using the OSMAC approach. Two isolates, Streptomyces sp.
Abdelhafez, Omnia Hesham, Abdelmohsen, Usama Ramadan, Fahim, John Refaat, Ngwa, Che J., Pradel, Gabriele, Rateb, Mostafa E.   +5 more
core   +2 more sources

Extending the “One Strain Many Compounds” (OSMAC) Principle to Marine Microorganisms

Marine Drugs, 2018
Genomic data often highlights an inconsistency between the number of gene clusters identified using bioinformatic approaches as potentially producing secondary metabolites and the actual number of chemically characterized secondary metabolites produced ...
Stefano Romano, Stephen A. Jackson, Sloane Patry, Alan D. W. Dobson   +3 more
doaj   +1 more source

Steroids Produced by Endophytic Fungus Lasiodiplodia Theobromae From Aglaia Argentea Blume and Their Cytotoxic Activity Against Hela Cervical Cancer Cell Lines [PDF]

, 2023
Three steroids, ergosterol (1), ergosterol peroxide (2) and stigmasterol (3) have been isolated from endophytic fungus, Lasiodiplodia theobromae derived from the root of Aglaia argentea Blume.
Azhari, Azmi, Harneti, Desi, Mulyani, Yeni, Purbaya, Sari, Sari, Aprilia Permata, Supratman, Unang, Wulandari, Asri Peni   +6 more
core   +2 more sources

Comparative Metabologenomics Analysis of Polar Actinomycetes

Marine Drugs, 2021
Biosynthetic and chemical datasets are the two major pillars for microbial drug discovery in the omics era. Despite the advancement of analysis tools and platforms for multi-strain metabolomics and genomics, linking these information sources remains a ...
Sylvia Soldatou, Grímur Hjörleifsson Eldjárn, Andrew Ramsay, Justin J. J. van der Hooft, Alison H. Hughes, Simon Rogers, Katherine R. Duncan   +6 more
doaj   +1 more source

Natural product libraries: Assembly, maintenance, and screening [PDF]

, 2014
This review discusses successful strategies and potential pitfalls to assembling a natural product-based library suitable for high-throughput screening. Specific extraction methods for plants, microorganisms, and marine invertebrates are detailed, along ...
Butler, Mark S., Cooper, Matthew A., Fontaine, Frank   +2 more
core   +1 more source

Highlighting the biotechnological potential of deep oceanic crust fungi through the prism of their antimicrobial activity [PDF]

, 2021
© The Author(s), 2021. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Quemener, M., Dayras, M., Frotté, N., Debaets, S., Le Meur, C., Barbier, G., Edgcomb, V., Mehiri, M., &
Barbier, Georges, Burgaud, Gaëtan, Dayras, Marie, Debaets, Stella, Edgcomb, Virginia P., Frotté, Nicolas, Le Meur, Christophe, Mehiri, Mohamed, Quemener, Maxence   +8 more
core   +2 more sources

Combining OSMAC, metabolomic and genomic methods for the production and annotation of halogenated azaphilones and ilicicolins in termite symbiotic fungi

Scientific Reports, 2022
We gathered a collection of termite mutualistic strains from French Guiana to explore the metabolites of symbiotic microorganisms. Molecular networks reconstructed from a metabolomic analysis using LC–ESI–MS/MS methodology led us to identify two families
Téo Hebra, Nicolas Pollet, David Touboul, Véronique Eparvier   +3 more
doaj   +1 more source

Optimization of Secondary Metabolite Production in the Sponge Associated Bacterium Roseivirga sp. PAP.19 Using the OSMAC Approach

Jurnal Ilmiah Perikanan dan Kelautan
Graphical Abstract  Highlight Research • Compounds produced by Roseivirga PAP.19 bacteria have potential as antimicrobials. • The OSMAC approach was used successfully to activate BGCs of Roseivirga PAP.19.
Andin Syamsi Pradani, Harwoko Harwoko, Maria Dyah Nur Meinita, Riviani Riviani, Ute Mettal, Riyanti   +5 more
doaj   +1 more source

Cyclic Tetrapeptides with Synergistic Antifungal Activity from the Fungus Aspergillus westerdijkiae Using LC-MS/MS-Based Molecular Networking

Antibiotics, 2022
Fungal natural products play a prominent role in the development of pharmaceuticalagents. Two new cyclic tetrapeptides (CTPs), westertide A (1) and B (2), with eight known compounds (3–10) were isolated from the fungus Aspergillus westerdijkiae guided by
Junjie Han, Hanying Wang, Rui Zhang, Huanqin Dai, Baosong Chen, Tao Wang, Jingzu Sun, Wenzhao Wang, Fuhang Song, Erwei Li, Zhitang Lyu, Hongwei Liu   +11 more
doaj   +1 more source