Results 71 to 80 of about 1,517 (182)

Editorial: Strategies for the Discovery of Fungal Natural Products [PDF]

, 2022
Strategies for the Discovery of Fungal Natural ...
Bills, Gerald F., Durán Patrón, Rosa María, Reyes, Fernando   +2 more
core   +1 more source

Co‐cultivation and Medium Optimization: A Strategy for Discovering Fungal‐derived Protease Inhibitors

Chemistry &Biodiversity, Volume 22, Issue 12, December 2025.
ABSTRACT The fungi Fusarium guttiforme and Phytophthora palmivora were cultivated in four different media (Potato Dextrose Agar, Czapek, rice, and ISP2) and co‐cultured to stimulate fungal interactions and enhance secondary metabolite production. Promising extracts were fractionated, yielding compounds such as the iron complex of fusaric acid (1 ...
Vitor de Souza Mazucato, Ludmilla Tonani, Marcia Regina von Zeska Kress, Adriano Defini Andricopulo, Gisele Barbosa, Renata Krogh, Leonardo Luiz Gomes Ferreira, Paulo Cezar Vieira   +7 more
wiley   +1 more source

Non‐Heme Iron Enzymes Catalyze Heterobicyclic and Spirocyclic Isoquinolone Core Formation in Piperazine Alkaloid Biosynthesis

Angewandte Chemie, Volume 136, Issue 20, May 13, 2024.
The biosynthesis of newly identified alkaloids featuring unique heterobicyclic and spirocyclic isoquinolone skeletons, arizonamides and arizolidines, has been characterized. Notably, the non‐heme iron enzyme ParG demonstrated catalytic versatility in multiple oxidative reactions, including cyclization and ring reconstruction.
Mai‐Truc Pham, Feng‐Ling Yang, I‐Chen Liu, Po‐Huang Liang, Hsiao‐Ching Lin   +4 more
wiley   +2 more sources

Enhanced Molecular Networking Shows Microbacterium sp. V1 as a Factory of Antioxidant Proline-Rich Peptides

Marine Drugs, 2023
Two linear proline-rich peptides (1–2), bearing an N-terminal pyroglutamate, were isolated from the marine bacterium Microbacterium sp. V1, associated with the marine sponge Petrosia ficiformis, collected in the volcanic CO2 vents in Ischia Island (South
Giovanni Andrea Vitale, Silvia Scarpato, Alfonso Mangoni, Maria Valeria D’Auria, Gerardo Della Sala, Donatella de Pascale   +5 more
doaj   +1 more source

Antimicrobial alkaloids produced by the mangrove endophyte Penicillium brocae MA-231 using the OSMAC approach

RSC Advances, 2017
The OSMAC (one strain-many compounds) protocol was used in this study to obtain various metabolites from the mangrove-derived endophytic fungus Penicillium brocae MA-231.
Ling-Hong Meng, Xiao-Ming Li, Yang Liu, Gang-Ming Xu, Bin-Gui Wang   +4 more
openaire   +2 more sources

Amazonian Cyanobacteria as a Source of Bioactive Compounds With Antimicrobial and Cytotoxic Properties

Chemistry &Biodiversity, Volume 22, Issue 12, December 2025.
ABSTRACT Cyanobacteria are photosynthetic microorganisms known for producing diverse bioactive compounds. This study explores the bioactivity of extracts and fractions from Amazonian cyanobacteria and their pigment and phenolic compound production. A fraction from Synechococcus sp. CACIAM 05 showed cytotoxicity against hCMEC/D3 and MG‐63 cells.
Samuel Cavalcante do Amaral, Luciana Pereira Xavier, Mariana Reis, Rhuana V. Médice, Janaína Morone, Raquel Silva, João Morais, Vitor Vasconcelos, Agenor Valadares Santos   +8 more
wiley   +1 more source

Time-variation study and OSMAC approach on fumonisin B1 and other mycotoxin production by Fusarium verticillioides.

, 2023
Abstract Fusarium verticillioides is a plant pathogenic fungus that can cause disease in a variety of crops, including corn, sorghum, and cotton. It is commonly found in soil, but can also be found in infected seeds and plant debris.
Emie Groppi, Alice Gadea, Valérie Cristofoli, Marieke Vansteelandt, Mohamed Haddad   +4 more
openaire   +1 more source

Exploring deep-sea Actinomycetota chemical diversity by using the OSMAC approach

Frontiers in Marine Science
The constant need to search for new drugs is a major driver for the discovery of new molecules of pharmaceutical interest. Natural products (NPs) of microbial origin have been recognized for their therapeutic properties, with Actinomycetota being one of ...
Sofia Correia, Sofia Correia, Inês Ribeiro, Andreia Braga-Henriques, Andreia Braga-Henriques, Andreia Braga-Henriques, Andreia Braga-Henriques, Andreia Braga-Henriques, Pedro N. Leão, Ralph Urbatzka, Maria F. Carvalho, Maria F. Carvalho   +11 more
doaj   +1 more source

Genome mining combined metabolic shunting and OSMAC strategy of an endophytic fungus leads to the production of diverse natural products

Acta Pharmaceutica Sinica B, 2021
Endophytic fungi are promising producers of bioactive small molecules. Bioinformatic analysis of the genome of an endophytic fungus Penicillium dangeardii revealed 43 biosynthetic gene clusters, exhibited its strong ability to produce numbers of ...
Qian Wei, Jian Bai, Daojiang Yan, Xiuqi Bao, Wenting Li, Bingyu Liu, Dan Zhang, Xiangbing Qi, Dequan Yu, Youcai Hu   +9 more
doaj   +1 more source

Integration of soft skills in the teaching of technical courses: an exploratory study of a private university / Hairuzila Idrus [PDF]

, 2013
Institutions of higher education have been pressed by the industry practitioners to produce quality graduates who are ready to compete in the competitive job market locally and globally.
Idrus, Hairuzila
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