Results 91 to 100 of about 93,007 (256)

New osmium-based reagent for the dihydroxylation of alkenes.

, 2006
The cis dihydroxylation of alkenes is most efficiently accomplished by reaction with osmium tetroxide. Recently, the expense and toxicity of osmium tetroxide have led to a number of attempts to harness alternative osmium-based reagents, including ...
Burrows, Jeremy N., Parker, JS, Burrows, JN, Donohoe, Timothy J., Donohoe, Timothy, Harris, RM, Butterworth, S, Parker, Jeremy S., Cowley, Andrew, Harris, Robert M., Cowley, A, Butterworth, Sam; id_orcid   +11 more
core   +1 more source

USP30‐Mediated Deubiquitination of PEX5 Suppresses Pexophagy to Drive Tubular Injury in Diabetic Kidney Disease

Advanced Science, EarlyView.
USP30 accumulation in diabetic renal tubular epithelial cells deubiquitinates PEX5, suppresses pexophagy, and drives dysfunctional peroxisome accumulation and tubular injury. USP30 depletion restores PEX5 ubiquitination and pexophagy, improves peroxisomal function, and alleviates tubular damage, highlighting USP30 as a therapeutic target in diabetic ...
Jia Li, Chaoyang Hua, Guangpu Li, Furong Zhai, Jingjing Ren, Shaokang Pan, Qi Feng, Jianguo Wen, Dongwei Liu, Zhangsuo Liu, Jiayu Duan   +10 more
wiley   +1 more source

A Micropeptide Component of the OGDH Complex Modulates ATP Production in the TCA Cycle

Advanced Science, EarlyView.
This study identified a mitochondrial micropeptide encoded by a non‐canonical open reading frame (alt‐ORF) within the CTSB gene. This micropeptide named APPM (ATP production‐promoting micropeptide) is a novel component of the OGDHc complex in the TCA cycle. APPM localizes to the inner mitochondrial membrane and directly binds to OGDH, the E1 subunit of
Xinqiang Yin, Weiyan Qi, Lifen Lin, Huilin Zheng, Guoxiang Zhao, Quan Chen, Guoqiang Shao, Yifan Wu, Jialiang Hu, Hanmei Xu   +9 more
wiley   +1 more source

COMPOSITION AND MORPHOLOGY OF CRYSTALS OF PLATINUM GROUP MINERALS FROM PLACERS OF THE SOUTH URALS [PDF]

Минералогия, 2017
Crystals of platinum group minerals (PGMs) of the Os–Ir–Ru and Pt–Fe systems from placer deposits of the South Urals are zonal and relatively homogenous in composition and can contain inclusions of PGE sulfides, arsenides, sulfarsenides, and antimonides.
V.V. Zaykov, V.A. Popov, E.V. Zaykova, I.A. Blinov, V.A. Kotlyarov   +4 more
doaj  

(Table 1) Rhenium and osmium concentrations and osmium isotopic results for composite altered samples at ODP Site 185-801

, 2008
(Table 1) Rhenium and osmium concentrations and osmium isotopic results for composite altered samples at ODP Site 185 ...
Staudigel, Hubert, Laurie Reisberg (6979361), Zimmermann, Catherine, Reisberg, Laurie, Olivier J Rouxel (6958442), Ludden, John N, John N Ludden (6958451), Hubert Staudigel (6961400), Rouxel, Olivier J, Catherine Zimmermann (7910648)   +9 more
core   +1 more source

Fzd7 Restrains Pink1‐Dependent Mitophagy in Suture Stem Cells to Maintain Cranial Suture Patency

Advanced Science, EarlyView.
How suture stem cells fail to preserve cranial suture patency remains incompletely understood. Integrated single‐cell and high‐resolution spatial transcriptomic analyses identify reduced Fzd7 expression in Prrx1+ suture stem cells as an early feature of craniosynostosis.
Xinyan Chen, Zong Chen, Chenzhi Lai, Yingying Yue, Tian He, Hao Gong, Jing Shi, Xiaoshuang Guo, Yu Wang, Guodong Song, Xiaolei Jin   +10 more
wiley   +1 more source

Pyridyl-Thiourea Ruthenium and Osmium Complexes: Coordination of Ligand and Application as FLP Hydrogenation Catalysts

Molecules
Pyridyl-thiourea complexes of formula [(Cym)MCl(κ2Npy,S-H2NNS)][SbF6] (Cym = η6-p-MeC6H4iPr; H2NNS = N-(p-tolyl)-N′-(2-pyridylmethyl)thiourea); M = Ru (1), Os (2)) were synthesized by reacting the corresponding metal dimers [{(Cym)MCl}2(μ-Cl)2] with ...
Alejandro Grasa, Roisin D. Leavey, Fernando Viguri, Ricardo Rodríguez, Pilar Lamata   +4 more
doaj   +1 more source

KLF5 Downregulation Links Impaired BNIP3‐Mediated Mitophagy to Inflammatory Valve Remodeling in Calcific Aortic Valve Disease

Advanced Science, EarlyView.
In human CAVD, KLF5 is reduced in VIC‐rich regions and remodeling/stress‐associated VIC states. In VICs, KLF5 sustains BNIP3 promoter activity and BNIP3‐mediated mitophagy, thereby limiting cytosolic mtDNA accumulation. KLF5 loss weakens mitochondrial quality control and enhances mtDNA‐sensitive STING/NF‐κB/NLRP3 inflammatory signaling under osteogenic
Jin‐Hui Bian, Jia‐Xi Gu, Zhang Yue, Chun‐Ze Yuan, Hai‐Bin Ji, Ao Li, Yu Zhong, Xiu‐Fan Xu, Yu‐Qiu He, Ye‐Fan Jiang, Hong‐Shan Chen, Xiang Chen, Meng‐Lin Chao, Yong‐Feng Shao   +13 more
wiley   +1 more source

Catalytic Analysis. VIII : Microdetermination of Osmium by a Reaction between Potassium Chlorate and Potassium Iodide [PDF]

, 2010
application/pdfPotassium chlorate and potassium iodide react slowly for themselves, but are accelerated by minute amount of osmium, hence applying this catalytic reaction, the microdetermination of osmium was accomplished.紀要類(bulletin)215411 ...
SHIOKAWA, Takanobu
core   +1 more source

ACSL4‐Dependent Lysosomal Lipid Peroxidation Links WTAP‐Mediated m6A Modification to Intervertebral Disc Degeneration

Advanced Science, EarlyView.
IL‐1β upregulates the protein level of WTAP, which promotes the m6A modification of ACSL4 mRNA in an IGF2BP2‐dependent manner, thereby enhancing its stability. The increased ACSL4 drives lipid peroxidation, leading to lysosomal membrane permeabilization (LMP) and impaired mitophagy, which collectively accelerate intervertebral disc degeneration (IVDD).
Shu Jia, Xu Gao, Laimin Zhu, Haixia Song, Jing Wu, Shang Chen, Sheng Gao, Lu Zhang, Chunyang Meng   +8 more
wiley   +1 more source