Results 81 to 90 of about 93,007 (256)

A Small‐Molecule DEPTAC Rescues Cognitive Deficits by Targeted Dephosphorylation of Pathological Tau

Advanced Science, EarlyView.
TP2 is a fully synthetic small‐molecule dephosphorylation‐targeting chimera that recruits endogenous PP2A‐Bα to Tau, enabling targeted removal of pathological phosphate modifications. In two tauopathy mouse models, systemic TP2 reduces Tau pathology, preserves neuronal and synaptic integrity, improves neuroimmune homeostasis, and rescues cognition ...
Fei Sun, Yang Liu, Qiuzhi Zhou, Qingyuan Hu, Weixia Wang, Yue Xiao, Jingfen Su, Guanting Liu, Miaomiao Sun, Lixia Chen, Hua Li, Ying Yang, Jian‐Zhi Wang   +12 more
wiley   +1 more source

MICROINCLUSIONS OF PGM MINERALS IN ANCIENT GOLD PRODUCTS: OCCURRENCE, COMPOSITION, ALTERATION [PDF]

Минералогия, 2015
The PGM microinclusions in ancient gold products from the Urals, Siberia, Azov region and Turkmenistan are compared with similar inclusions from the Middle East artifacts. Microinclusions were found in the archaeological sites, which are located close to
V.V. Zaykov, P.K. Dashkovsky, E.V. Zaykova, V.A. Kotlyarov, A.M. Yuminov, I.A. Blinov   +5 more
doaj  

Preparation of Diazoalkane Complexes of Osmium(II)

, 2016
Preparation of Diazoalkane Complexes of Osmium ...
Gabriele Albertin (1647244), Barbara Carrera (2980104), Stefano Antoniutti (1647241), Emilio Bordignon (2971953)   +3 more
core   +1 more source

Polystyrene Nanoplastics Drive β‐Cell Dedifferentiation Through Dendritic Cell‐Intrinsic MHC‐I‐Dependent Inflammatory Crosstalk

Advanced Science, EarlyView.
Polystyrene nanoplastics disrupt pancreatic immune–endocrine homeostasis by promoting MHC‐I‐associated dendritic cell activation and inflammatory crosstalk with β cells. This immune remodeling drives β‐cell dedifferentiation, impairs insulin secretion, and aggravates metabolic dysfunction, revealing a previously unrecognized immunometabolic mechanism ...
Conghui Qiao, Yuqing Song, Fang Yang, Menghui Guo, Libin Jiang, Xiaoyue Quan, Wei Wei, Xinyang Wang, Tianshu Han, Mingyuan Liu, Wenbo Jiang   +10 more
wiley   +1 more source

Influence of Transition Metals on Animal and Human Health: A Review

Contemporary Agriculture, 2018
Niobium, osmium, scandium, tungsten and vanadium are transition metals naturally occuring in the environment, particularly in the Earth’s crust. Anthropogenic activities, primarily industrial technologies, have precipitated significant alternations in ...
Bilčíková Jana, Fialková Veronika, Kováčiková Eva, Miškeje Michal, Tombarkiewicz Barbara, Kňažická Zuzana   +5 more
doaj   +1 more source

Is Osmium Diboride An Ultra-Hard Material?

, 2016
Is Osmium Diboride An Ultra-Hard ...
Hong Sun (132232), Changfeng Chen (1289595), Jun Yang (2084)   +2 more
core   +1 more source

A Multidimensional Engineering Strategy Reprograms Microglia via Targeted and Sustained‐Release Extracellular Vesicles for Spinal Cord Injury Repair

Advanced Science, EarlyView.
A multifunctional EV‐based nanoplatform (Ang‐TEVs@Gel) was engineered via preconditioning, surface targeting, and ROS‐responsive hydrogel encapsulation to reprogram microglia. This system restored autophagy via miR‐664a‐3p/PIK3CA axis, cleared myelin debris, resolved neuroinflammation, and promoted axon remyelination, ultimately achieving robust motor ...
Wu Xiong, Minhao Liu, Mingming Zheng, Jizhou Jia, Ziyan Zhu, Guang Kong, Jie Liu, Juan Wang, Wenbo Li, Qingyuan Wang, Qian Zhu, Peiran Chan, Tao Qin, Jiayang Wu, Yongjie Zhang, Chunming Tang, Cong Li, Jin Fan   +17 more
wiley   +1 more source

Interaction of potassium hexahalogenoosmates(IV) with DMSO

Тонкие химические технологии, 2013
Interaction of К2 [OsX6], where X=Cl, Br ( СOs = n · 10-4 – n · 10-2 mol/l) with DMSO has been studied by electronic absorption spectroscopy at room temperature and heating.
O. V. Rudnitskaya, Е. К. Kultyshkina, Е. V. Dobrokhotova   +2 more
doaj  

Nucleoside‐Modified mRNA Encoding Alpha‐Galactosidase A Ameliorates Fabry Disease Phenotypes in Human IPSC‐Derived Cardiomyocytes

Advanced Science, EarlyView.
Human iPSC‐derived Fabry cardiomyocytes exhibited broad transcriptional dysregulation, apoptosis, mitochondrial dysfunction, impaired reactive oxygen species handling, altered contractility, and abnormal calcium transient decay, potentially mediated by phospholamban hyperphosphorylation.
Malte Juchem, Lea Oehlsen, Sedef Ersoy, Jia Li Ye, Natalie Weber, Elisa Mohr, Wilson Agyapong, Junqing Liu, Maximilian Fuchs, Ke Xiao, Christopher Jahn, Reto Eggenschwiler, Tobias Cantz, Julia Beimdiek, Falk F. R. Buettner, Theresia Kraft, Jan Hegermann, Ivonne J. Knorr, Lisa Ernst, Linda Feldbrügge, Resa Puffert, Kevin Schmidt, Christian Bär, Jeannine Hoepfner, Thomas Thum   +24 more
wiley   +1 more source

Double staining method for array tomography using scanning electron microscopy

Applied Microscopy, 2020
Scanning electron microscopy (SEM) plays a central role in analyzing structures by imaging a large area of brain tissue at nanometer scales. A vast amount of data in the large area are required to study structural changes of cellular organelles in a ...
Eunjin Kim, Jiyoung Lee, Seulgi Noh, Ohkyung Kwon, Ji Young Mun   +4 more
doaj   +1 more source