Results 101 to 110 of about 302,871 (285)
Advanced Science, EarlyView.The loss of Ubiquitin Specific Peptidase 26 (USP26) in osteoblasts results in decreased bone formation, as well as multi‐organ fibrosis associated with insulin resistance (IR). Mechanistically, the absence of USP26 reduces glycolysis and lactate accumulation, leading to decreased histone H3 lysine 18 lactylation (H3K18LA) in the promoter region of KH ...
Jiyuan Tang +9 more
wiley +1 more source
Serum proteomic biomarkers diagnostic of knee osteoarthritis [PDF]
, 2021 Ann M. Reed +8 more
openalex +1 more source
Advanced Science, EarlyView.This study reveals that XBP1s drives production of circTspan3, a circular RNA that strengthens cartilage by boosting anabolic activity and limiting cell death. Phosphorylated ANXA2 directs circTspan3 into exosomes, enabling paracrine repair. Exosomal circTspan3 expands growth‐plate cartilage and promotes in vivo regeneration, highlighting its promise ...
Yiming Pan +16 more
wiley +1 more source
Fibular osteotomy is helpful for talar reduction in the treatment of varus ankle osteoarthritis with supramalleolar osteotomy [PDF]
, 2021 Jingqi Liang +8 more
openalex +1 more source
Organic Electrochemical Transistors in Tissue‐Interfaced Bioelectronics
Advanced Science, EarlyView.This article reviews the design, fabrication, and biological application of organic electrochemical transistors (OECTs), emphasizing their potential in tissue‐interfaced bioelectronics. It covers the fundamental principles of OECTs, strategies for enhancing tissue interfacing, and the development of skin‐mounted and implantable systems.
Ruixiang Bai, Zeyu Zhao, Feng Yan
wiley +1 more source
Lifetime Risk And Genetic Predisposition To Post-Traumatic Osteoarthritis Of The Knee: Time-To-Event And Related Analyses In The Uk Biobank [PDF]
, 2023 B. Hollis +8 more
openalex +1 more source
Advanced Science, EarlyView.Traditionally considered sterile, the articular cavity is now recognized to harbor microbial communities influencing osteoarthritis (OA). Integrating 16S rRNA sequencing and culturomics, Micrococcus luteus is enriched in advanced OA. Notably, M. luteus G18 exacerbates cartilage degeneration via TLR2/JNK/AP‐1‐mediated ECM disruption, revealing intra ...
Tingtao Chen +6 more
wiley +1 more source
Transcutaneous Vagal Nerve Stimulation Reduces Pain And Histological Osteoarthritis In Destabilization Of The Medial Meniscal Mouse Model [PDF]
, 2023 M. Humphrey +10 more
openalex +1 more source