Results 141 to 150 of about 693,773 (371)
Advanced Healthcare Materials, EarlyView.Bone fracture healing is a complex, timely orchestrated scenario involving multiple cell types and a plethora of cytokines and regulatory factors. To gain further insight, an in vitro model to a) study macrophage polarization under mechanical load in a fibrin hydrogel and b) subsequently assess the effect of conditioned media derived from macrophages ...
Anne Géraldine Guex +4 more
wiley +1 more source
Nature Communications, 2017 The pathogenesis of osteoarthritis is unclear. The authors show that estrogen-related receptor gamma is upregulated in cartilage from patients and mouse models, where it drives production of matrix-degrading MMPs in chondrocytes, and that its ...
Young-Ok Son +10 more
doaj +1 more source
European Medical Journal, 2018 Ageing is a complex process of accumulation of molecular, cellular, and organ damage, leading to loss of function and increased vulnerability to disease and death, the rate and extent of which varies among individuals. Osteoarthritis (OA) is not only the most common joint disease, but is also one of the major causes of disability in people aged >65 ...
Valdes, Ana M., Stocks, Joanne
openaire +2 more sources
Cell Calcification Models and Their Implications for Medicine and Biomaterial Research
Advanced Healthcare Materials, EarlyView.Calcification, is the process by which the tissues containing minerals are formed, occurring during normal physiological processes, or in pathological conditions. Here, it is aimed to give a comprehensive overview of the range of cell models available, and the approaches taken by these models, highlighting when and how methodological divergences arise,
Luke Hunter +5 more
wiley +1 more source
Modulation of TGF-beta signaling by proinflammatory cytokines in articular chondrocytes. [PDF]
, 2007 OBJECTIVE: The normal structure and function of articular cartilage are the result of a precisely balanced interaction between anabolic and catabolic processes.
Jimenez, Sergio A. +2 more
core +1 more source
Advanced Healthcare Materials, EarlyView.Meniscal microtissues are fabricated using progenitor cells isolated from the inner (iMPCs) and outer (oMPCs) regions of the meniscus. Meniscal microtissues fuse into cohesive constructs rich in sGAG and collagen. cABC treatment modulates collagen fiber formation and organization in assembled grafts.
Gabriela S. Kronemberger +4 more
wiley +1 more source
Conducting Polymer Coatings for Bioelectronic Arthroscopy Probes
Advanced Healthcare Materials, EarlyView.Schematic of a poly(3,4‐ethylenedioxythiophene, PEDOT)‐coated arthroscopy probe, featuring a semi‐spherical probe with 38 microelectrodes, used to measure streaming potential generated during cartilage indentation in the knee. The inset includes a scanning electron microscopy (SEM) image of the porous PEDOT layer deposited on a nickel‐phosphorus coated
Sara Ebrahimi +6 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.A modular bioreactor platform was developed in order to replicate bone homeostasis and pathology, thereby integrating mechanical loading, dynamic perfusion, and a 3D‐printed microfluidic chamber. With precise control of environmental parameters and dual perfusion for composite tissue models, the system enhances physiological relevance for studying bone
Moritz Pfeiffenberger +8 more
wiley +1 more source
Anxiety and depression prevalence and associated factors in patients with knee osteoarthritis
Frontiers in PsychiatryObjectiveWith the evolving spectrum of diseases, psychological conditions such as anxiety and depression have emerged as significant global public health concerns.
Qizhen Feng +4 more
doaj +1 more source