Results 11 to 20 of about 212,125 (236)

Osteoarthritis [PDF]

Nature Reviews Disease Primers, 2016
Osteoarthritis (OA) is the most common joint disorder, is associated with an increasing socioeconomic impact owing to the ageing population and mainly affects the diarthrodial joints. Primary OA results from a combination of risk factors, with increasing age and obesity being the most prominent.
Johanne, Martel-Pelletier, Andrew J, Barr, Flavia M, Cicuttini, Philip G, Conaghan, Cyrus, Cooper, Mary B, Goldring, Steven R, Goldring, Graeme, Jones, Andrew J, Teichtahl, Jean-Pierre, Pelletier   +9 more
  +8 more sources

Osteoarthritis [PDF]

Disease-a-Month, 2006
Osteoarthritis (OA), the syndrome of joint pain and dysfunction caused by joint degeneration, affects more people than any other joint disease. In most instances joint degeneration develops in the absence of an identifiable cause, but increasing age, excessive joint loading, and joint abnormalities and insults increase the risk of OA. Articular surface
David J, Hunter, David T, Felson
  +7 more sources

Osteoarthritis

British Journal of Hospital Medicine, 2014
Osteoarthritis is nowadays one of the most frequent chronic diseases and, with the increase in life expectancy, both its prevalence and incidence is expected to rise. This condition is progressive and leads to functional decline and loss in quality of life, with important health care and society costs.
Philip, Courtney, Michael, Doherty
openaire   +6 more sources

Memory CD8+ T Cell Protection From Viral Reinfection Depends on Interleukin-33 Alarmin Signals

Frontiers in Immunology, 2019
Memory CD8+ cytotoxic T lymphocytes (CTLs) can protect against viral reinfection. However, the signals driving rapid memory CTL reactivation have remained ill-defined.
Claudia Baumann, Claudia Baumann, Anja Fröhlich, Anja Fröhlich, Tobias M. Brunner, Tobias M. Brunner, Vivien Holecska, Vivien Holecska, Daniel D. Pinschewer, Max Löhning, Max Löhning   +10 more
doaj   +1 more source

A continuous data driven translational model to evaluate effectiveness of population-level health interventions: case study, smoking ban in public places on hospital admissions for acute coronary events

Journal of Translational Medicine, 2020
Background An important task in developing accurate public health intervention evaluation methods based on historical interrupted time series (ITS) records is to determine the exact lag time between pre- and post-intervention.
Hossein Bonakdari, Jean-Pierre Pelletier, Johanne Martel-Pelletier   +2 more
doaj   +1 more source

Mass spectrometry-based proteomics identify novel serum osteoarthritis biomarkers

Arthritis Research & Therapy, 2022
Background Osteoarthritis (OA) is a slowly developing and debilitating disease, and there are no validated specific biomarkers for its early detection.
Ginette Tardif, Frédéric Paré, Clarisse Gotti, Florence Roux-Dalvai, Arnaud Droit, Guangju Zhai, Guang Sun, Hassan Fahmi, Jean-Pierre Pelletier, Johanne Martel-Pelletier   +9 more
doaj   +1 more source

Is there a mitochondrial DNA haplogroup connection between osteoarthritis and elite athletes? A narrative review

RMD Open, 2022
Elite athletes are at greater risk of joint injuries linked to the subsequent risk of developing osteoarthritis (OA). Genetic factors such as mitochondrial (mt) DNA haplogroups have been associated with the incidence/progression of OA and athletic ...
Jean-Pierre Pelletier, Johanne Martel-Pelletier   +1 more
doaj   +1 more source

Randomized, double-blind, placebo-controlled study to evaluate the effect of treatment with an SPMs-enriched oil on chronic pain and inflammation, functionality, and quality of life in patients with symptomatic knee osteoarthritis: GAUDI study

Journal of Translational Medicine, 2023
Background Specialized pro-resolving mediators (SPMs), including 18-HEPE, 17-HDHA, and 14-HDHA are recognized as potentially therapeutic in inflammatory diseases because SPMs regulate the inflammation process, which leads to, for example; swelling and ...
Ingrid Möller, Gil Rodas, Jose María Villalón, Jose A. Rodas, Francisco Angulo, Nina Martínez, Josep Vergés   +6 more
doaj   +1 more source

Impact of oral osteoarthritis therapy usage among other risk factors on knee replacement: a nested case-control study using the Osteoarthritis Initiative cohort

Arthritis Research & Therapy, 2018
Background The aim of this study was to measure the association between exposure to commonly used oral osteoarthritis (OA) therapies and relevant confounding risk factors on the occurrence of knee replacement (KR), using the Osteoarthritis Initiative ...
Marc Dorais, Johanne Martel-Pelletier, Jean-Pierre Raynauld, Philippe Delorme, Jean-Pierre Pelletier   +4 more
doaj   +1 more source

STING mediates experimental osteoarthritis and mechanical allodynia in mouse

Arthritis Research & Therapy, 2023
Background This study was performed to develop therapeutic targets of osteoarthritis (OA) that can be targeted to alleviate OA development (i.e., cartilage destruction) and relieve the OA-associated joint pain.
Youngnim Shin, Deborah Cho, Seul Ki Kim, Jang-Soo Chun   +3 more
doaj   +1 more source