Results 11 to 20 of about 275,512 (248)

A continuous data driven translational model to evaluate effectiveness of population-level health interventions: case study, smoking ban in public places on hospital admissions for acute coronary events

Journal of Translational Medicine, 2020
Background An important task in developing accurate public health intervention evaluation methods based on historical interrupted time series (ITS) records is to determine the exact lag time between pre- and post-intervention.
Hossein Bonakdari, Jean-Pierre Pelletier, Johanne Martel-Pelletier   +2 more
doaj   +1 more source

Mass spectrometry-based proteomics identify novel serum osteoarthritis biomarkers

Arthritis Research & Therapy, 2022
Background Osteoarthritis (OA) is a slowly developing and debilitating disease, and there are no validated specific biomarkers for its early detection.
Ginette Tardif, Frédéric Paré, Clarisse Gotti, Florence Roux-Dalvai, Arnaud Droit, Guangju Zhai, Guang Sun, Hassan Fahmi, Jean-Pierre Pelletier, Johanne Martel-Pelletier   +9 more
doaj   +1 more source

Randomized, double-blind, placebo-controlled study to evaluate the effect of treatment with an SPMs-enriched oil on chronic pain and inflammation, functionality, and quality of life in patients with symptomatic knee osteoarthritis: GAUDI study

Journal of Translational Medicine, 2023
Background Specialized pro-resolving mediators (SPMs), including 18-HEPE, 17-HDHA, and 14-HDHA are recognized as potentially therapeutic in inflammatory diseases because SPMs regulate the inflammation process, which leads to, for example; swelling and ...
Ingrid Möller, Gil Rodas, Jose María Villalón, Jose A. Rodas, Francisco Angulo, Nina Martínez, Josep Vergés   +6 more
doaj   +1 more source

STING mediates experimental osteoarthritis and mechanical allodynia in mouse

Arthritis Research & Therapy, 2023
Background This study was performed to develop therapeutic targets of osteoarthritis (OA) that can be targeted to alleviate OA development (i.e., cartilage destruction) and relieve the OA-associated joint pain.
Youngnim Shin, Deborah Cho, Seul Ki Kim, Jang-Soo Chun   +3 more
doaj   +1 more source

Impact of oral osteoarthritis therapy usage among other risk factors on knee replacement: a nested case-control study using the Osteoarthritis Initiative cohort

Arthritis Research & Therapy, 2018
Background The aim of this study was to measure the association between exposure to commonly used oral osteoarthritis (OA) therapies and relevant confounding risk factors on the occurrence of knee replacement (KR), using the Osteoarthritis Initiative ...
Marc Dorais, Johanne Martel-Pelletier, Jean-Pierre Raynauld, Philippe Delorme, Jean-Pierre Pelletier   +4 more
doaj   +1 more source

Temporal trends in incidence of time-loss injuries in four male professional North American sports over 13 seasons

Scientific Reports, 2021
Sports-related injuries increase healthcare cost burden, and in some instances have harmful long term physical and psychological implications. There is currently a lack of comprehensive data on temporal injury trends across professional North American ...
Garrett S. Bullock, Elizabeth Murray, Jake Vaughan, Stefan Kluzek   +3 more
doaj   +1 more source

Dynamic weight-bearing test during jumping: A sensitive outcome measure of chronic osteoarthritis pain in rats

Heliyon, 2021
Pain due to osteoarthritis (OA) often occurs during locomotion in the vertical direction when joints are subjected to high mechanical load, e.g. during standing up from a chair or using stairs.
Andreas Westhof, Kerstin Kleinschmidt-Doerr, Martin Michaelis, Christian Brenneis   +3 more
doaj  

Levels of serum biomarkers from a two-year multicentre trial are associated with treatment response on knee osteoarthritis cartilage loss as assessed by magnetic resonance imaging: an exploratory study

Arthritis Research & Therapy, 2017
Background There is an obvious need to identify biomarkers that could predict patient response to an osteoarthritis (OA) treatment. This post hoc study explored in a 2-year randomized controlled trial in patients with knee OA, the likelihood of some ...
Johanne Martel-Pelletier, Jean-Pierre Raynauld, François Mineau, François Abram, Patrice Paiement, Philippe Delorme, Jean-Pierre Pelletier   +6 more
doaj   +1 more source

Role of epigenetics and the transcription factor Sp1 in the expression of the D prostanoid receptor 1 in human cartilage

Frontiers in Cell and Developmental Biology, 2023
D prostanoid receptor 1 (DP1), a prostaglandin D2 receptor, plays a central role in the modulation of inflammation and cartilage metabolism. We have previously shown that activation of DP1 signaling downregulated catabolic responses in cultured ...
Mehdi Najar, Sami G. Alsabri, Gadid G. Guedi, Makram Merimi, Frédéric Lavoie, Detlev Grabs, Jean-Pierre Pelletier, Johanne Martel-Pelletier, Mohamed Benderdour, Hassan Fahmi   +9 more
doaj   +1 more source

Exploring determinants predicting response to intra-articular hyaluronic acid treatment in symptomatic knee osteoarthritis: 9-year follow-up data from the Osteoarthritis Initiative

Arthritis Research & Therapy, 2018
Background The weight of recommendation for intra-articular therapies such as hyaluronic acid injections varies from one set of guidelines to another, and they have not yet reached unanimity with respect to the usefulness of intra-articular hyaluronic ...
Jean-Pierre Pelletier, Jean-Pierre Raynauld, François Abram, Marc Dorais, Philippe Delorme, Johanne Martel-Pelletier   +5 more
doaj   +1 more source