Results 31 to 40 of about 313,441 (304)

Levels of serum biomarkers from a two-year multicentre trial are associated with treatment response on knee osteoarthritis cartilage loss as assessed by magnetic resonance imaging: an exploratory study

open access: yesArthritis Research & Therapy, 2017
Background There is an obvious need to identify biomarkers that could predict patient response to an osteoarthritis (OA) treatment. This post hoc study explored in a 2-year randomized controlled trial in patients with knee OA, the likelihood of some ...
Johanne Martel-Pelletier   +6 more
doaj   +1 more source

Temporal trends in incidence of time-loss injuries in four male professional North American sports over 13 seasons

open access: yesScientific Reports, 2021
Sports-related injuries increase healthcare cost burden, and in some instances have harmful long term physical and psychological implications. There is currently a lack of comprehensive data on temporal injury trends across professional North American ...
Garrett S. Bullock   +3 more
doaj   +1 more source

Role of epigenetics and the transcription factor Sp1 in the expression of the D prostanoid receptor 1 in human cartilage

open access: yesFrontiers in Cell and Developmental Biology, 2023
D prostanoid receptor 1 (DP1), a prostaglandin D2 receptor, plays a central role in the modulation of inflammation and cartilage metabolism. We have previously shown that activation of DP1 signaling downregulated catabolic responses in cultured ...
Mehdi Najar   +9 more
doaj   +1 more source

Pulsed electromagnetic energy treatment offers no clinical benefit in reducing the pain of knee osteoarthritis: a systematic review [PDF]

open access: yes, 2006
Background The rehabilitation of knee osteoarthritis often includes electrotherapeutic modalities as well as advice and exercise. One commonly used modality is pulsed electromagnetic field therapy (PEMF).
Michael James Callaghan   +12 more
core   +1 more source

Quantitative sensory testing in painful hand osteoarthritis demonstrates features of peripheral sensitisation. [PDF]

open access: yes, 2012
Hand osteoarthritis (HOA) is a prevalent condition for which treatments are based on analgesia and physical therapies. Our primary objective was to evaluate pain perception in participants with HOA by assessing the characteristics of nodal involvement ...
Hermansson, M   +5 more
core   +1 more source

Exploring determinants predicting response to intra-articular hyaluronic acid treatment in symptomatic knee osteoarthritis: 9-year follow-up data from the Osteoarthritis Initiative

open access: yesArthritis Research & Therapy, 2018
Background The weight of recommendation for intra-articular therapies such as hyaluronic acid injections varies from one set of guidelines to another, and they have not yet reached unanimity with respect to the usefulness of intra-articular hyaluronic ...
Jean-Pierre Pelletier   +5 more
doaj   +1 more source

A Machine Learning Model to Predict Knee Osteoarthritis Cartilage Volume Changes over Time Using Baseline Bone Curvature

open access: yesBiomedicines, 2022
The hallmark of osteoarthritis (OA), the most prevalent musculoskeletal disease, is the loss of cartilage. By using machine learning (ML), we aimed to assess if baseline knee bone curvature (BC) could predict cartilage volume loss (CVL) at one year, and ...
Hossein Bonakdari   +3 more
doaj   +1 more source

The role of cumulative physical work load in symptomatic knee osteoarthritis : a case-control study in Germany

open access: yes, 2008
Objectives To examine the dose-response relationship between cumulative exposure to kneeling and squatting as well as to lifting and carrying of loads and symptomatic knee osteoarthritis (OA) in a population-based case-control study.
Nasreddin Abolmaali   +12 more
core   +1 more source

Global management of patients with knee osteoarthritis begins with quality of life assessment: a systematic review

open access: yesBMC Musculoskeletal Disorders, 2019
Background Knee osteoarthritis (KOA) is a prevalent form of chronic joint disease associated with functional restrictions and pain. Activity limitations negatively impact social connectedness and psychological well-being, reducing the quality of life ...
Marianna Vitaloni   +15 more
doaj   +1 more source

A patients’ view of OA: the Global Osteoarthritis Patient Perception Survey (GOAPPS), a pilot study

open access: yesBMC Musculoskeletal Disorders, 2020
Background Globally, osteoarthritis (OA) is the third condition associated with disability. There is still poor treatment in OA but science holds the key to finding better treatments and a cure.
Marianna Vitaloni   +19 more
doaj   +1 more source

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