Results 21 to 30 of about 313,441 (304)

Protease-activated receptor 2: a novel pathogenic pathway in a murine model of osteoarthritis [PDF]

, 2010
<b>Objective:</b> Osteoarthritis is a global clinical challenge for which no effective disease-modifying agents currently exist. This study identified protease-activated receptor 2 (PAR-2) as a novel pathogenic mechanism and potential ...
McInnes, I.B., Lockhart, J.C., Plevin, R., Elizabeth B Kelso, Robin Plevin, Iain B McInnes, Ferrell, W.R., Kelso, E.B., Plevin, R.J., William R Ferrell, John C Lockhart   +10 more
core   +1 more source

Mass spectrometry-based proteomics identify novel serum osteoarthritis biomarkers

Arthritis Research & Therapy, 2022
Background Osteoarthritis (OA) is a slowly developing and debilitating disease, and there are no validated specific biomarkers for its early detection.
Ginette Tardif, Frédéric Paré, Clarisse Gotti, Florence Roux-Dalvai, Arnaud Droit, Guangju Zhai, Guang Sun, Hassan Fahmi, Jean-Pierre Pelletier, Johanne Martel-Pelletier   +9 more
doaj   +1 more source

Balance and gait adaptations in patients with early knee osteoarthritis [PDF]

, 2014
Gait adaptations in people with severe knee osteoarthritis (OA) have been well documented, with increased knee adduction moments (KAM) the most commonly reported parameter.
Gulati, Vivek, McGregor, Alison H., Duffell, LD, Gulati, V, McGregor, AH, Southgate, Dominic F.L., Southgate, DFL, Duffell, Lynsey D.   +7 more
core   +1 more source

Randomized, double-blind, placebo-controlled study to evaluate the effect of treatment with an SPMs-enriched oil on chronic pain and inflammation, functionality, and quality of life in patients with symptomatic knee osteoarthritis: GAUDI study

Journal of Translational Medicine, 2023
Background Specialized pro-resolving mediators (SPMs), including 18-HEPE, 17-HDHA, and 14-HDHA are recognized as potentially therapeutic in inflammatory diseases because SPMs regulate the inflammation process, which leads to, for example; swelling and ...
Ingrid Möller, Gil Rodas, Jose María Villalón, Jose A. Rodas, Francisco Angulo, Nina Martínez, Josep Vergés   +6 more
doaj   +1 more source

Impact of oral osteoarthritis therapy usage among other risk factors on knee replacement: a nested case-control study using the Osteoarthritis Initiative cohort

Arthritis Research & Therapy, 2018
Background The aim of this study was to measure the association between exposure to commonly used oral osteoarthritis (OA) therapies and relevant confounding risk factors on the occurrence of knee replacement (KR), using the Osteoarthritis Initiative ...
Marc Dorais, Johanne Martel-Pelletier, Jean-Pierre Raynauld, Philippe Delorme, Jean-Pierre Pelletier   +4 more
doaj   +1 more source

STING mediates experimental osteoarthritis and mechanical allodynia in mouse

Arthritis Research & Therapy, 2023
Background This study was performed to develop therapeutic targets of osteoarthritis (OA) that can be targeted to alleviate OA development (i.e., cartilage destruction) and relieve the OA-associated joint pain.
Youngnim Shin, Deborah Cho, Seul Ki Kim, Jang-Soo Chun   +3 more
doaj   +1 more source

Potential directions for drug development for osteoarthritis [PDF]

, 2008
Background: osteoarthritis (OA) is a frustrating disease for both patient and physician because neither cause nor cure is known and there are currently no disease-modifying drugs.
Roach, Helmtrud I.
core   +1 more source

Self-reported adult footwear and the risks of lower limb osteoarthritis : the GOAL case control study [PDF]

, 2014
Background: Biomechanical factors may play a role in osteoarthritis (OA) development and progression. Previous biomechanical studies have indicated that types of footwear may modulate forces across the knee joint, and high heeled womens’ shoes in ...
Muthuri, Stella, Weiya Zhang, Zhang, W, Muthuri, S, Rose A Maciewicz, Maciewicz, Rose A., Muir, Kenneth, Doherty, M, Stella Muthuri, McWilliams, Daniel F., McWilliams, D F, Daniel F McWilliams, Muir, Kenneth R., Maciewicz, R A, Kenneth R Muir, Michael Doherty, Zhang, Weiya, Muir, K R; id_orcid, Doherty, Michael   +18 more
core   +1 more source

Correction: The role of cumulative physical work load in symptomatic knee osteoarthritis – a case–control study in Germany (Seidler et al. 2008) [PDF]

, 2012
: In the original paper (Seidler et al. 2008), there is a mistake in the results of the occupational group analysis. This mistake occurred when the core data set was merged with the occupational group data.
Seidler, Andreas, Nasreddin Abolmaali, Elsner, Gine, Ulrich Bolm-Audorff, Bolm-Audorff, Ulrich, Abolmaali, Nasreddin, Andreas Seidler, Gine Elsner   +7 more
core   +1 more source

Global, regional, and national burden of osteoarthritis, 1990–2020 and projections to 2050: a systematic analysis for the Global Burden of Disease Study 2021 [PDF]

, 2023
Background Osteoarthritis is the most common form of arthritis in adults, characterised by chronic pain and loss of mobility. Osteoarthritis most frequently occurs after age 40 years and prevalence increases steeply with age.
GBD 2021 Osteoarthritis Collaborators
core   +1 more source