Results 21 to 30 of about 28,700 (204)
Arthritis Research & Therapy, 2018 Background The aim of this study was to measure the association between exposure to commonly used oral osteoarthritis (OA) therapies and relevant confounding risk factors on the occurrence of knee replacement (KR), using the Osteoarthritis Initiative ...
Marc Dorais +4 more
doaj +1 more source
STING mediates experimental osteoarthritis and mechanical allodynia in mouse
Arthritis Research & Therapy, 2023 Background This study was performed to develop therapeutic targets of osteoarthritis (OA) that can be targeted to alleviate OA development (i.e., cartilage destruction) and relieve the OA-associated joint pain.
Youngnim Shin +3 more
doaj +1 more source
Arthritis Research & Therapy, 2017 Background There is an obvious need to identify biomarkers that could predict patient response to an osteoarthritis (OA) treatment. This post hoc study explored in a 2-year randomized controlled trial in patients with knee OA, the likelihood of some ...
Johanne Martel-Pelletier +6 more
doaj +1 more source
Scientific Reports, 2021 Sports-related injuries increase healthcare cost burden, and in some instances have harmful long term physical and psychological implications. There is currently a lack of comprehensive data on temporal injury trends across professional North American ...
Garrett S. Bullock +3 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2023 D prostanoid receptor 1 (DP1), a prostaglandin D2 receptor, plays a central role in the modulation of inflammation and cartilage metabolism. We have previously shown that activation of DP1 signaling downregulated catabolic responses in cultured ...
Mehdi Najar +9 more
doaj +1 more source
Biomedicines, 2022 The hallmark of osteoarthritis (OA), the most prevalent musculoskeletal disease, is the loss of cartilage. By using machine learning (ML), we aimed to assess if baseline knee bone curvature (BC) could predict cartilage volume loss (CVL) at one year, and ...
Hossein Bonakdari +3 more
doaj +1 more source
Arthritis Research & Therapy, 2018 Background The weight of recommendation for intra-articular therapies such as hyaluronic acid injections varies from one set of guidelines to another, and they have not yet reached unanimity with respect to the usefulness of intra-articular hyaluronic ...
Jean-Pierre Pelletier +5 more
doaj +1 more source
BMC Musculoskeletal Disorders, 2019 Background Knee osteoarthritis (KOA) is a prevalent form of chronic joint disease associated with functional restrictions and pain. Activity limitations negatively impact social connectedness and psychological well-being, reducing the quality of life ...
Marianna Vitaloni +15 more
doaj +1 more source
A patients’ view of OA: the Global Osteoarthritis Patient Perception Survey (GOAPPS), a pilot study
BMC Musculoskeletal Disorders, 2020 Background Globally, osteoarthritis (OA) is the third condition associated with disability. There is still poor treatment in OA but science holds the key to finding better treatments and a cure.
Marianna Vitaloni +19 more
doaj +1 more source
An unusual midfoot injury pattern: Navicular-cuneiform and calcaneal-cuboid fracture-dislocation
Trauma Case Reports, 2022 Fracture-dislocations of the midfoot are relatively rare injuries. We present a case of a 20-year-old man presenting with navicular-cuneiform and calcaneal-cuboid fracture-dislocation of his right foot due to a crush injury during work.
Ali Fares +3 more
doaj +1 more source