Diclofenac solution (Pennsaid) in the management of osteoarthritis of the knee : Patient implications [PDF]
, 2009 Topical diclofenac sodium (pennsaid) is a non-steroidal-anti- inflammatory drug that is used to manage the recurrent pain and symptoms of osteoarthritis of the knee. Pennsaid is applied topically, absorbed cutaneously and concentrates locally at the site
Banning, M
core +6 more sources
Protease-activated receptor 2: a novel pathogenic pathway in a murine model of osteoarthritis [PDF]
, 2010 <b>Objective:</b> Osteoarthritis is a global clinical challenge for which no effective disease-modifying agents currently exist. This study identified protease-activated receptor 2 (PAR-2) as a novel pathogenic mechanism and potential ...
McInnes, I.B. +10 more
core +4 more sources
The use of topical diclofenac in the pain management of osteoarthritis of the knee [PDF]
, 2006 Osteoarthritis (OA) is a common complaint that affects millions of people worldwide. As there is no cure for OA, drug treatment is the main form of management.
Banning, M
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The role of cumulative physical work load in symptomatic knee osteoarthritis : a case-control study in Germany [PDF]
, 2008 Objectives To examine the dose-response relationship between cumulative exposure to kneeling and squatting as well as to lifting and carrying of loads and symptomatic knee osteoarthritis (OA) in a population-based case-control study.
Nasreddin Abolmaali +12 more
core +1 more source
Primary cilia disassembly down regulates mechanosensitive hedgehog signalling: a feedback mechanism controlling ADAMTS-5 expression in chondrocytes [PDF]
, 2014 SummaryObjectiveHedgehog signalling is mediated by the primary cilium and promotes cartilage degeneration in osteoarthritis. Primary cilia are influenced by pathological stimuli and cilia length and prevalence are increased in osteoarthritic cartilage ...
Knight, M.M. +5 more
core +1 more source
Memory CD8+ T Cell Protection From Viral Reinfection Depends on Interleukin-33 Alarmin Signals
Frontiers in Immunology, 2019 Memory CD8+ cytotoxic T lymphocytes (CTLs) can protect against viral reinfection. However, the signals driving rapid memory CTL reactivation have remained ill-defined.
Claudia Baumann +10 more
doaj +1 more source
Journal of Translational Medicine, 2020 Background An important task in developing accurate public health intervention evaluation methods based on historical interrupted time series (ITS) records is to determine the exact lag time between pre- and post-intervention.
Hossein Bonakdari +2 more
doaj +1 more source
Mass spectrometry-based proteomics identify novel serum osteoarthritis biomarkers
Arthritis Research & Therapy, 2022 Background Osteoarthritis (OA) is a slowly developing and debilitating disease, and there are no validated specific biomarkers for its early detection.
Ginette Tardif +9 more
doaj +1 more source
RMD Open, 2022 Elite athletes are at greater risk of joint injuries linked to the subsequent risk of developing osteoarthritis (OA). Genetic factors such as mitochondrial (mt) DNA haplogroups have been associated with the incidence/progression of OA and athletic ...
Jean-Pierre Pelletier +1 more
doaj +1 more source
The Complexity of Human Walking: A Knee Osteoarthritis Study [PDF]
, 2014 This study proposes a framework for deconstructing complex walking patterns to create a simple principal component space before checking whether the projection to this space is suitable for identifying changes from the normality.
Duffell, LD +7 more
core +2 more sources