Results 21 to 30 of about 693,773 (371)

Prokineticin 2 is a catabolic regulator of osteoarthritic cartilage destruction in mouse

Arthritis Research & Therapy, 2023
Background Our preliminary study indicates that the multi-functional protein, prokineticin 2 (Prok2), is upregulated in osteoarthritic (OA) chondrocytes as a target of the hypoxia-inducible factor (HIF)-2α.
Jiye Yang, Youngnim Shin, Hwee-Jin Kim, Hyo-Eun Kim, Jang-Soo Chun   +4 more
doaj   +1 more source

In silico targeting of interleukin-6 by natural compounds

Bangladesh Journal of Pharmacology, 2014
Rheumatoid arthritis an autoimmune disorder affecting many tissues and organs, is a challenging prospect in terms of treatment. Our work is looking into finding lead compound of natural origin against IL-6, an important cyto-kine having a profound role ...
Wei Zhou, Jun-Feng Cai, Feng Yuan, Min Ma, Feng Yin   +4 more
doaj   +1 more source

Therapeutic Effect of Exosomes Derived From Stem Cells in Spinal Cord Injury: A Systematic Review Based on Animal Studies

Frontiers in Neurology, 2022
ObjectiveA systematic review of the role of stem cell-derived exosomes in repairing spinal cord injury (SCI) and the existing problems in animal experiments to provide a reference for better animal experiments and clinical studies in the future ...
Cangyu Zhang, Cangyu Zhang, Rongrong Deng, Guangzhi Zhang, Guangzhi Zhang, Xuegang He, Xuegang He, Haiwei Chen, Haiwei Chen, Bao Chen, Bao Chen, Lin Wan, Lin Wan, Xuewen Kang, Xuewen Kang   +14 more
doaj   +1 more source

Modifications of Gait as Predictors of Natural Osteoarthritis Progression in STR/Ort Mice [PDF]

, 2014
Objective. Osteoarthritis (OA) is a common chronic disease for which disease-modifying therapies are not currently available. Studies to seek new targets for slowing the progress of OA rely on mouse models, but these do not allow for longitudinal ...
Poulet, B, De Souza, R, Knights, C B, Gentry, C, Wilson, A M, Bevan, S, Chang, Y M, Pitsillides, A A, Fed Mato Grosso, King's, UCL   +10 more
core   +8 more sources

Two or four injections of platelet-rich plasma for osteoarthritic knee did not change synovial biomarkers but similarly improved clinical outcomes

Scientific Reports, 2021
We compared two and four intra-articular injections of platelet-rich plasma (PRP) in terms of changes of synovial cytokines and clinical outcomes. One hundred twenty-five patients having knee osteoarthritis (OA) underwent PRP injections at a 6-week ...
Srihatach Ngarmukos, Chotetawan Tanavalee, Chavarin Amarase, Suphattra Phakham, Warayapa Mingsiritham, Rangsima Reantragoon, Nitigorn Leearamwat, Thidarat Kongkaew, Kittipan Tharakhet, Sittisak Honsawek, Sinsuda Dechsupa, Aree Tanavalee   +11 more
doaj   +1 more source

The potential for dietary factors to prevent or treat osteoarthritis [PDF]

, 2014
Osteoarthritis (OA) is a degenerative joint disease for which there are no disease-modifying drugs. It is a leading cause of disability in the UK. Increasing age and obesity are both major risk factors for OA and the health and economic burden of this ...
Bao, Yongping, Cassidy, Aedín, Clark, Ian M., Davidson, Rose K., Donell, Simon T., Green, Jonathan A., Hirst-Jones, Kimberley L., Jupp, Orla, Macgregor, Alexander J.   +8 more
core   +1 more source

Update on osteoarthritis part 1: current concepts and the relation to exercise [PDF]

, 2002
There appears to be an increased risk of lower limb osteoarthritis in participants of repetitive, high impact sports, and this is strongly associated with joint injury. There seems to be little risk associated with recreational running.
Conaghan, P.
core   +2 more sources

Memory CD8+ T Cell Protection From Viral Reinfection Depends on Interleukin-33 Alarmin Signals

Frontiers in Immunology, 2019
Memory CD8+ cytotoxic T lymphocytes (CTLs) can protect against viral reinfection. However, the signals driving rapid memory CTL reactivation have remained ill-defined.
Claudia Baumann, Claudia Baumann, Anja Fröhlich, Anja Fröhlich, Tobias M. Brunner, Tobias M. Brunner, Vivien Holecska, Vivien Holecska, Daniel D. Pinschewer, Max Löhning, Max Löhning   +10 more
doaj   +1 more source

A continuous data driven translational model to evaluate effectiveness of population-level health interventions: case study, smoking ban in public places on hospital admissions for acute coronary events

Journal of Translational Medicine, 2020
Background An important task in developing accurate public health intervention evaluation methods based on historical interrupted time series (ITS) records is to determine the exact lag time between pre- and post-intervention.
Hossein Bonakdari, Jean-Pierre Pelletier, Johanne Martel-Pelletier   +2 more
doaj   +1 more source

Mass spectrometry-based proteomics identify novel serum osteoarthritis biomarkers

Arthritis Research & Therapy, 2022
Background Osteoarthritis (OA) is a slowly developing and debilitating disease, and there are no validated specific biomarkers for its early detection.
Ginette Tardif, Frédéric Paré, Clarisse Gotti, Florence Roux-Dalvai, Arnaud Droit, Guangju Zhai, Guang Sun, Hassan Fahmi, Jean-Pierre Pelletier, Johanne Martel-Pelletier   +9 more
doaj   +1 more source