Results 21 to 30 of about 432,246 (250)
Journal of Translational Medicine, 2023 Background Specialized pro-resolving mediators (SPMs), including 18-HEPE, 17-HDHA, and 14-HDHA are recognized as potentially therapeutic in inflammatory diseases because SPMs regulate the inflammation process, which leads to, for example; swelling and ...
Ingrid Möller +6 more
doaj +1 more source
Memory CD8+ T Cell Protection From Viral Reinfection Depends on Interleukin-33 Alarmin Signals
Frontiers in Immunology, 2019 Memory CD8+ cytotoxic T lymphocytes (CTLs) can protect against viral reinfection. However, the signals driving rapid memory CTL reactivation have remained ill-defined.
Claudia Baumann +10 more
doaj +1 more source
RMD Open, 2022 Elite athletes are at greater risk of joint injuries linked to the subsequent risk of developing osteoarthritis (OA). Genetic factors such as mitochondrial (mt) DNA haplogroups have been associated with the incidence/progression of OA and athletic ...
Jean-Pierre Pelletier +1 more
doaj +1 more source
Pathophysiology of osteoarthritis [PDF]
Osteoarthritis and Cartilage, 1998 Osteoarthritis (OA) is characterized by a degeneration of articular cartilage, in which the breakdown leads to matrix fibrillation, fissure appearance, gross ulceration, and fullthickness loss of the joint surface. This is accompanied by hypertrophic bone changes with osteophyte formation and subchondral bone plate thickening.
openaire +6 more sources
STING mediates experimental osteoarthritis and mechanical allodynia in mouse
Arthritis Research & Therapy, 2023 Background This study was performed to develop therapeutic targets of osteoarthritis (OA) that can be targeted to alleviate OA development (i.e., cartilage destruction) and relieve the OA-associated joint pain.
Youngnim Shin +3 more
doaj +1 more source
Epidemiology of Osteoarthritis [PDF]
Clinics in Geriatric Medicine, 2008 Osteoarthritis (OA) is the most common joint disorder in the United States. Symptomatic knee OA occurs in 10% men and 13% in women aged 60 years or older. The number of people affected with symptomatic OA is likely to increase due to the aging of the population and the obesity epidemic.
Yuqing Zhang, Joanne M. Jordan
openaire +6 more sources
Scientific Reports, 2021 Sports-related injuries increase healthcare cost burden, and in some instances have harmful long term physical and psychological implications. There is currently a lack of comprehensive data on temporal injury trends across professional North American ...
Garrett S. Bullock +3 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2023 D prostanoid receptor 1 (DP1), a prostaglandin D2 receptor, plays a central role in the modulation of inflammation and cartilage metabolism. We have previously shown that activation of DP1 signaling downregulated catabolic responses in cultured ...
Mehdi Najar +9 more
doaj +1 more source
Update on osteoarthritis part 1: current concepts and the relation to exercise [PDF]
, 2002 There appears to be an increased risk of lower limb osteoarthritis in participants of repetitive, high impact sports, and this is strongly associated with joint injury. There seems to be little risk associated with recreational running.
Conaghan, P.
core +2 more sources
Arthritis Research & Therapy, 2018 Background The aim of this study was to measure the association between exposure to commonly used oral osteoarthritis (OA) therapies and relevant confounding risk factors on the occurrence of knee replacement (KR), using the Osteoarthritis Initiative ...
Marc Dorais +4 more
doaj +1 more source