Results 31 to 40 of about 693,773 (371)

Is there a mitochondrial DNA haplogroup connection between osteoarthritis and elite athletes? A narrative review

RMD Open, 2022
Elite athletes are at greater risk of joint injuries linked to the subsequent risk of developing osteoarthritis (OA). Genetic factors such as mitochondrial (mt) DNA haplogroups have been associated with the incidence/progression of OA and athletic ...
Jean-Pierre Pelletier, Johanne Martel-Pelletier   +1 more
doaj   +1 more source

Mild acetabular dysplasia and risk of osteoarthritis of the hip : a case-control study [PDF]

, 2010
Objective To determine whether mild variation in acetabular depth (AD) and shape is a risk factor for osteoarthritis (OA) of the hip. Methods The unaffected contralateral hip of patients with unilateral hip OA was compared with hips of asymptomatic ...
Doherty, Michael, Doherty, Sally A., Jenkins, Wendy D., Maciewicz, Rose A., McWilliams, Daniel F., Muir, Kenneth, Zhang, Weiya   +6 more
core   +1 more source

Pathophysiology of osteoarthritis [PDF]

Osteoarthritis and Cartilage, 1998
Osteoarthritis (OA) is characterized by a degeneration of articular cartilage, in which the breakdown leads to matrix fibrillation, fissure appearance, gross ulceration, and fullthickness loss of the joint surface. This is accompanied by hypertrophic bone changes with osteophyte formation and subchondral bone plate thickening.
openaire   +6 more sources

The use of equine chondrogenic‐induced mesenchymal stem cells as a treatment for osteoarthritis : a randomised, double‐blinded, placebo‐controlled proof‐of‐concept study [PDF]

, 2019
Background: There is a need to improve therapies for osteoarthritis in horses. Objectives To assess the efficacy of equine allogeneic chondrogenic-induced mesenchymal stem cells combined with equine allogeneic plasma as a novel therapy for osteoarthritis
Bertone, AL, Broeckx, Sarah, Chiers, Koen, Duchateau, Luc, Dumoulin, Michèle, Hussein, H, Martens, Ann, Oosterlinck, Maarten, Pille, Frederik, Spaas, JH, Van Brantegem, Leen, Van Hecke, L   +11 more
core   +1 more source

Randomized, double-blind, placebo-controlled study to evaluate the effect of treatment with an SPMs-enriched oil on chronic pain and inflammation, functionality, and quality of life in patients with symptomatic knee osteoarthritis: GAUDI study

Journal of Translational Medicine, 2023
Background Specialized pro-resolving mediators (SPMs), including 18-HEPE, 17-HDHA, and 14-HDHA are recognized as potentially therapeutic in inflammatory diseases because SPMs regulate the inflammation process, which leads to, for example; swelling and ...
Ingrid Möller, Gil Rodas, Jose María Villalón, Jose A. Rodas, Francisco Angulo, Nina Martínez, Josep Vergés   +6 more
doaj   +1 more source

Femoroacetabular impingement: a cause for osteoarthritis of the hip.

Clinical Orthopaedics and Related Research, 2003
A multitude of factors including biochemical, genetic, and acquired abnormalities may contribute to osteoarthritis of the hip. Although the pathomechanism of degenerative process affecting the dysplastic hip is well understood, the exact pathogenesis for
R. Ganz, J. Parvizi, M. Beck, M. Leunig, H. Nötzli, K. Siebenrock   +5 more
semanticscholar   +1 more source

The genetic contribution to severe post-traumatic osteoarthritis [PDF]

, 2013
Objective: to compare the combined role of genetic variants loci associated with risk of knee or hip osteoarthritis (OA) in post-traumatic (PT) and non-traumatic (NT) cases of clinically severe OA leading to total joint replacement.
Ana M Valdes, Anderson, arcOGEN Consortium and arcOGEN Collaborators, Brown, Castaño-Betancourt, Day-Williams, Dieppe, Doherty, Englund, Evangelou, Herrero-Beaumont, Kenneth R Muir, Lopez, Margaret Wheeler, Michael Doherty, Muthuri, Rose A Maciewicz, Sally A Doherty, Sward, Valdes, Valdes, Weiya Zhang   +21 more
core   +1 more source

Acupuncture randomized trials (ART) in patients with chronic low back pain and osteoarthritis of the knee - Design and protocols [PDF]

, 2003
Background: We report on the study design and protocols of two randomized controlled trials (Acupuncture Randomized Trials = ART) that investigate the efficacy of acupuncture in the treatment of chronic low back pain and osteoarthritis of the knee ...
Becker-Witt, C., Brinkhaus, Benno, Hummelsberger, J., Irnich, D., Jena, S., Linde, K., Melchart, Dieter, Streng, A., Wagenpfeil, S., Willich, S. N.   +9 more
core   +1 more source

Impact of oral osteoarthritis therapy usage among other risk factors on knee replacement: a nested case-control study using the Osteoarthritis Initiative cohort

Arthritis Research & Therapy, 2018
Background The aim of this study was to measure the association between exposure to commonly used oral osteoarthritis (OA) therapies and relevant confounding risk factors on the occurrence of knee replacement (KR), using the Osteoarthritis Initiative ...
Marc Dorais, Johanne Martel-Pelletier, Jean-Pierre Raynauld, Philippe Delorme, Jean-Pierre Pelletier   +4 more
doaj   +1 more source

STING mediates experimental osteoarthritis and mechanical allodynia in mouse

Arthritis Research & Therapy, 2023
Background This study was performed to develop therapeutic targets of osteoarthritis (OA) that can be targeted to alleviate OA development (i.e., cartilage destruction) and relieve the OA-associated joint pain.
Youngnim Shin, Deborah Cho, Seul Ki Kim, Jang-Soo Chun   +3 more
doaj   +1 more source