Results 31 to 40 of about 275,413 (149)

Playing sport injured is associated with osteoarthritis, joint pain and worse health-related quality of life: a cross-sectional study

BMC Musculoskeletal Disorders, 2020
Background Sports participants are faced with the decision to continue or cease play when injured. The implications of playing sport while injured on joint health and health-related quality of life (HRQoL) has not been investigated.
Garrett S. Bullock, Gary S. Collins, Nick Peirce, Nigel K. Arden, Stephanie R. Filbay   +4 more
doaj   +1 more source

RNA-binding protein ZFP36L1 regulates osteoarthritis by modulating members of the heat shock protein 70 family

Nature Communications, 2019
Osteoarthritis is characterised by degeneration of joint cartilage. Here the authors show that the RNA-binding protein ZFP36L1 is upregulated in chondrocytes of humans and mice with osteoarthritis, and that its knockdown in mouse joints protects ...
Young-Ok Son, Hyo-Eun Kim, Wan-Su Choi, Churl-Hong Chun, Jang-Soo Chun   +4 more
doaj   +1 more source

A randomized controlled trial of teriparatide for accelerating bone union and improving clinical outcomes in patients with pertrochanteric fracture fixation

Scientific Reports
This prospective, double-blind, placebo-controlled, randomized trial evaluated the effects of teriparatide following pertrochanteric fracture fixation on bone healing and clinical outcomes.
Chotetawan Tanavalee, Srihatach Ngarmukos, Chavarin Amarase, Saran Tantavisut, Nonn Jaruthien, Aree Tanavalee   +5 more
doaj   +1 more source

Sprifermin (rhFGF18) modulates extracellular matrix turnover in cartilage explants ex vivo

Journal of Translational Medicine, 2017
Background Sprifermin (recombinant human fibroblast growth factor 18) is in clinical development as a potential disease-modifying osteoarthritis drug (DMOAD).
Ditte Reker, Cecilie F. Kjelgaard-Petersen, Anne Sofie Siebuhr, Martin Michaelis, Anne Gigout, Morten A. Karsdal, Christoph Ladel, Anne C. Bay-Jensen   +7 more
doaj   +1 more source

Complicated thromboembolic prophylaxis in the treatment of septic gonitis – case report

Pediatria i Medycyna Rodzinna, 2015
In this paper the case of a patient subjected to orthopaedic treatment with a history of a number of internal comorbidities, cardiac ones in particular, has been reported. Cardiac comorbidities were related to the implantation of a VVI pacemaker.
Adrian Brychcy, Wojciech J. Marczyński, Stanisław Rak   +2 more
doaj   +1 more source

Circ_0020014 mediates CTSB expression and participates in IL-1β-prompted chondrocyte injury via interacting with miR-24-3p

Journal of Orthopaedic Surgery and Research, 2023
Background Recent studies have shown that circRNAs are involved in the pathogenesis of osteoarthritis (OA) by affecting various fundamental cellular characteristics of chondrocytes.
Chenpeng Zhang, Wenjun He
doaj   +1 more source

Aging and Osteoarthritis: An Inevitable Encounter?

Journal of Aging Research, 2012
Osteoarthritis (OA) is a major health burden of our time. Age is the most prominent risk factor for the development and progression of OA. The mechanistic influence of aging on OA has different facets.
Thomas Hügle, Jeroen Geurts, Corina Nüesch, Magdalena Müller-Gerbl, Victor Valderrabano   +4 more
doaj   +1 more source

Hand Osteoarthritis: investigating Pain Effects of estrogen-containing therapy (HOPE-e): a protocol for a feasibility randomised placebo-controlled trial

Pilot and Feasibility Studies, 2021
Background Hand osteoarthritis (OA) is a common condition, causing pain, stiffness and reduced quality of life. Incidence is higher amongst women, particularly around the age of the menopause.
Ioana R. Marian, Megan Goff, Jennifer A. E. Williams, Malvika Gulati, Mae Chester-Jones, Anne Francis, Marion Watson, Tonia L. Vincent, Sue Woollacott, Charles Mackworth-Young, Victoria Glover, Dominic Furniss, Matthew Gardiner, Sarah E. Lamb, Katy Vincent, Vicki S. Barber, Joanna Black, Susan J. Dutton, Fiona E. Watt   +18 more
doaj   +1 more source

THE OPERATIVE TREATMENT OF OSTEOARTHRITIS. [PDF]

, 1916
W. I. d. C. Wheeler
openalex   +2 more sources

An unusual midfoot injury pattern: Navicular-cuneiform and calcaneal-cuboid fracture-dislocation

Trauma Case Reports, 2022
Fracture-dislocations of the midfoot are relatively rare injuries. We present a case of a 20-year-old man presenting with navicular-cuneiform and calcaneal-cuboid fracture-dislocation of his right foot due to a crush injury during work.
Ali Fares, Benoit Orfeuvre, Morad Abou Al Ezz, Régis Pailhe   +3 more
doaj