Results 71 to 80 of about 99 (99)

Organoid‐tissue extracellular vesicles

Interdisciplinary Medicine, EarlyView.
Abstract Extracellular vesicles (EVs) are lipid bilayer structures secreted by cells that act as intercellular messengers. Tissue‐derived EVs (TEVs), harvested from the tissue interstitium, directly reflect the actual physiological or pathological state of the tissue microenvironment.
Han Liu, Ting Cheng, Guangfeng Li, Zhidao Xia, Chenglong Wang, Ke Xu, Jiacan Su   +6 more
wiley   +1 more source

Association of UCMA With Cartilage Pathogenesis and Inflammation in Patients With Rheumatoid Arthritis: A Novel Biomarker

Journal of Clinical Laboratory Analysis, EarlyView.
The study of 98 RA patients and 24 healthy controls found significantly higher serum levels of UCMA, COMP, TNF‐α, and IL‐6 in RA patients. ROC curve analysis showed that these markers could differentiate RA from healthy controls. UCMA correlates with inflammation and cartilage degeneration, suggesting its potential as a diagnostic marker.
Münteha Nur Sonuç Karaboğa, Hamza Malik Okuyan, Serdar Dogan, Hamdi Oguzman, Gezmiş Kimyon   +4 more
wiley   +1 more source

Genetically‐targeted control of the spinal cord and peripheral nervous system

Journal of Intelligent Medicine, EarlyView.
Application of genetically‐targeted stimulation for treating diseases or injuries outside the brain. Optogenetic and chemogenetic systems have been developed for dysfunction in the cochlea, spinal cord, dorsal root ganglia (DRGs), peripheral nerves, lower urinary tract, and enteric nervous system (ENS). Created with Biorender.com.
Anakaren Romero Lozano, Victoria Koptelova, Zoya Ahmad, Huiliang (Evan) Wang   +3 more
wiley   +1 more source

Current Landscape of Short‐T2 Imaging Techniques in the Musculoskeletal System: The Past, Present and Future

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Conventional MRI is limited in imaging tissues with short T2 relaxation times, such as bone, ligaments, and cartilage, due to their rapid signal decay. This limitation has spurred the development of specialized MRI techniques designed specifically for short‐T2 tissue imaging.
Pranjal Rai, Amit Kumar Janu, Nitin Shetty, Suyash Kulkarni   +3 more
wiley   +1 more source

Radiographer Preferences for Shoulder x‐Ray Imaging in Australia: A National Survey

Journal of Medical Radiation Sciences, EarlyView.
A national, cross‐sectional online survey obtained data on the views and combination of views preferred by Australian radiographers across five common pathological presentations. The results demonstrate a wide variation in image preferences of Australian radiographers performing shoulder imaging.
Zoe Moran, Amber Loh, Annie K. Lewis, Paul Kelly, Amy M. Dennett   +4 more
wiley   +1 more source

Proteomics Reveals Increased Periostin in Synovial Fluid From Canine and Human Anterior Cruciate Ligament Injury

Journal of Orthopaedic Research, EarlyView.
ABSTRACT Posttraumatic osteoarthritis (PTOA) is a common sequela to anterior cruciate ligament (ACL) injury in humans and dogs. Identification of conserved targets between species may hasten biomarker identification and therapeutic development. To identify differentially regulated synovial fluid (SF) proteins in ACL injury, SF samples were collected ...
Sydney J. Womack, Camila B. Carballo, Erica J. Secor, Scott A. Rodeo, Heidi L. Reesink   +4 more
wiley   +1 more source

Pain Assessment in Osteoarthritis: Present Practices and Future Prospects Including the Use of Biomarkers and Wearable Technologies, and AI‐Driven Personalized Medicine

Journal of Orthopaedic Research, EarlyView.
ABSTRACT Osteoarthritis (OA) is a highly prevalent chronic joint disorder affecting ~600 million individuals worldwide and is characterized by complex pain mechanisms that significantly impair patient quality of life. Challenges exist in accurately assessing and measuring pain in OA due to variations in pain perception among individuals and the ...
Shujaa T. Khan, Nick Huffman, Xiaojuan Li, Anukriti Sharma, Carl S. Winalski, Eric T. Ricchetti, Kathleen Derwin, Suneel S. Apte, Daniel Rotroff, Carl Y. Saab, Nicolas S. Piuzzi   +10 more
wiley   +1 more source

The Influence of Cup Orientation on the Primary Fixation of a Hemispherical Cementless Acetabular Cup: A Cohort Based Finite Element Study

Journal of Orthopaedic Research, EarlyView.
ABSTRACT Cup orientation has been investigated in detail with respect to risk of dislocation, however, the impact on the primary fixation of cementless cups is poorly understood. The aim of this study was to assess the influence acetabular component orientation on the primary fixation of cementless acetabular cups using an in silico clinical trial ...
Mark Taylor, Stuart Callary, Dominic Thewlis, Rebecca Bryan   +3 more
wiley   +1 more source

Automated Acetabular Defect Reconstruction and Analysis for Revision Total Hip Arthroplasty: A Computational Modeling Study

Journal of Orthopaedic Research, EarlyView.
ABSTRACT Revision total hip arthroplasty (rTHA) involving large acetabular defects is associated with high early failure rates, primarily due to cup loosening. Most acetabular defect classification systems used in surgical planning are based on planar radiographs and do not encapsulate three‐dimensional geometry and morphology of the acetabular defect.
Daniel Hopkins, Stuart A. Callary, L. Bogdan Solomon, Peter V. S. Lee, David C. Ackland   +4 more
wiley   +1 more source

Unilateral Single Joint Arthritis Changes Joint Power in Unaffected Joints

Journal of Orthopaedic Research, EarlyView.
ABSTRACT Pain and disability associated with arthritis of the hip, knee, or ankle is well‐documented. However, data on joint power and how arthritis in one joint affects power in that joint and in unaffected joints are limited. This study asks if arthritis in any one joint leads to (1) loss of power in that affected joint compared to the contralateral,
James Campbell, Daniel Schmitt, Laura P. Sands, Robin M. Queen   +3 more
wiley   +1 more source