Results 141 to 150 of about 128,752 (251)

Sheep Horn Development Revealed by Multi‐Tissue and Cross‐Species Transcriptomic Analysis

Animal Research and One Health, EarlyView.
Multi‐tissue and cross‐species transcriptomics with allele‐specific expression show sheep horns are a composite organ integrating epidermal and osteogenic programs. Conserved horn gene modules and cis‐regulatory variation fine‐tune expression networks underlying horn development and size (small scurs vs. large spiral horns).
Hao Li, Yuchen He, Yangshuo Hu, Naominggaowa, Huaiqiang Yang, Zhu Meng, Fei Liu, Shiwen Zhang, Yi Jin, Mingxing Chu, Zhangyuan Pan   +10 more
wiley   +1 more source

Complement Proteins C1q-C5 as Context‑Dependent Regulators of Osteoblast Function and Fracture Healing: A Systematic Review. [PDF]

Orthop Rev (Pavia)
Counts PR, Baer TM, Viswanath O, Ganti L.   +3 more
europepmc   +1 more source

T cells, the Next Big Target in Axial Spondyloarthritis?

Arthritis &Rheumatology, EarlyView.
Axial spondyloarthritis (axSpA) is a chronic inflammatory disease characterized by complex immune dysregulation, with T cells playing a central role in its pathogenesis. In this review, we synthesize current knowledge on diverse T cell subsets in axSpA, their pathogenic mechanisms, and emerging therapeutic strategies targeting these cells. We highlight
Mansi K. Aparnathi, Nigil Haroon
wiley   +1 more source

The Role of Ferroptosis Induced by Iron Overload in Osteoblast and Osteoclast Function. [PDF]

Cell Biol Int
Sooksawanwit S, Lertsuwan K, Tannop N, Lapatkeattisukul P, Jenpichitkulchai T, Sotapong N, Teerapornpuntakit J, Khunluck T, Punvilai S, Charoenphandhu N.   +9 more
europepmc   +1 more source

CD248/Endosialin Regulates Synovial Fibroblast State to Control Coupling of Inflammation and Bone Damage in Murine Models of Immune‐Mediated Inflammatory Arthritis and Aging

Arthritis &Rheumatology, EarlyView.
Objective Synovial fibroblasts directly contribute to inflammation and damage in immune‐mediated inflammatory arthritis. CD248/endosialin is expressed by fibroblasts in the synovium, is highly up‐regulated during inflammation, and has been proposed as a potential therapeutic target.
Samuel Kemble, Corinna Wehmeyer, James M. Brown, Charlotte G. Smith, Holly R. Adams, Eva Crombie, Ellie Northall, Maryam Imran, Paulynn Chin, Harris R. Perlman, Christopher D. Buckley, Adam P. Croft, Amy J. Naylor   +12 more
wiley   +1 more source

Reprogramming bone homeostasis: The recoupling-oriented framework of bidirectional regulation strategies for osteoporosis. [PDF]

iScience
Niu J, Li Z, Zou Y, Wang Z, Kang J, Zhang Y, Wang S, Liu R, Han X.   +8 more
europepmc   +1 more source

Dual Effects of β‐TrCP2 Deletion in Bone Homeostasis: Suppression of Osteoclastogenesis and Enhancement of Osteoblast Activity

Arthritis &Rheumatology, EarlyView.
Objective The aim of this study was to elucidate the role of beta‐transducin repeat‐containing protein 2 (β‐TrCP2) in bone homeostasis for its potential as a therapeutic target for osteoporosis. Methods The role of β‐TrCP2 in bone phenotypes was investigated using systemic β‐TrCP1 knockout (KO) and β‐TrCP2KO mice, along with myeloid‐specific ...
Woo Jung Kim, Sora Han, Hye In Ka, Sun Young Lee, Jiwon Kim, Hyunjeong Joo, Sujung Soh, Gaeun Oh, Kyung Hyun Yoo, Seung Hyun Han, Yeongkag Kwon, Choogon Lee, Kyung‐Hyun Park‐Min, Se Hwan Mun, Young Yang   +14 more
wiley   +1 more source

Epigenetic regulatory networks in the pathogenesis and treatment of osteoporosis subtypes. [PDF]

Mol Biomed
Ren Z, Dai B, Chen D, Li Z, Meng K, Lan S, Liu C, Zhang Z, Mo X.   +8 more
europepmc   +1 more source

Plasma Proteomics Identifies Molecular Signatures and Biomarkers Associated With High Structural Damage in Ankylosing Spondylitis

Arthritis &Rheumatology, EarlyView.
Objective Pathologic bone formation in ankylosing spondylitis (AS) is not fully reflected by systemic inflammation, limiting the utility of markers of inflammation for structural damage assessment. This study aimed to identify plasma protein signatures associated with structural damage severity in AS.
Tiantian Sun, Wanlin Liu, Kun Yang, Xiaohan Xu, Yu Wang, Xinning Qu, Yifan Gong, Wenya Zhang, Jie Ma, Hongxiao Liu   +9 more
wiley   +1 more source

Effects of simvastatin-loaded polymeric micelles on human osteoblast-like MG-63 cells

, 2012
To develop an optimized simvastatin (SV) delivery device for bone regeneration, SV-loaded poly(ethylene glycol)-poly(ɛ-caprolactone) (PECL) micelles were constructed. The micelles had an average size of 80 nm.
Shaobing Li, Qiangbin Wang(王强斌), Zhonglei Wang, Jianwu Dai(戴建武), Xiaoran Li(李晓然), Yan Gao, Haibin Lu, Ying Jiang, Xiangning Liu(刘湘宁), Lei Zhou, Jie Sun(孙杰)   +10 more
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