Results 201 to 210 of about 38,017 (252)
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Transcription factors and osteoblasts
Frontiers in Bioscience, 1998Transcription factors play a key role in determination of the fate of the cells in osteoblastic and chondrocytic lineage. A runt family member, Cbfa, is indispensable for osteoblastic differentiation. Sox 9 and scleraxis are involved in the phenotypic expression in chondrocytes and the cells of early stage connective tissues.
M, Noda +7 more
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Osteoblast and chondroblast differentiation
Bone, 1995Recognition of discrete commitment and differentiation stages requires characterization of changes in proliferative capacity together with the temporal acquisition or loss of expression of molecular and morphological traits. Both cell lines and primary cultures have been useful for analysis of transitional steps in the chondroblast (CB) and osteoblast (
J E, Aubin +3 more
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Blood, 2008
In this issue of Blood , Mayak and Wagers report on a new method to isolate putative osteoblastic cells that can regulate hematopoietic stem cell proliferation and function. The cellular and extracellular matrix components that support and regulate hematopoietic stem cells (HSCs) form niches ...
Daniel, Lucas, Paul S, Frenette
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In this issue of Blood , Mayak and Wagers report on a new method to isolate putative osteoblastic cells that can regulate hematopoietic stem cell proliferation and function. The cellular and extracellular matrix components that support and regulate hematopoietic stem cells (HSCs) form niches ...
Daniel, Lucas, Paul S, Frenette
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Osteoclast–osteoblast communication
Archives of Biochemistry and Biophysics, 2008Cells in osteoclast and osteoblast lineages communicate with each other through cell-cell contact, diffusible paracrine factors and cell-bone matrix interaction. Osteoclast-osteoblast communication occurs in a basic multicellular unit (BMU) at the initiation, transition and termination phases of bone remodeling.
Koichi, Matsuo, Naoko, Irie
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Medical Hypotheses, 2012
Bisphosphonates are used in the oncological setting to treat and prevent skeletal-related events and preserve bone mineral density. Bisphosphonates also possess a hypocalcaemic effect. When undesired, hypocalcaemia can result in increased morbidity and complications.
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Bisphosphonates are used in the oncological setting to treat and prevent skeletal-related events and preserve bone mineral density. Bisphosphonates also possess a hypocalcaemic effect. When undesired, hypocalcaemia can result in increased morbidity and complications.
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Bisphosphonates: effects on osteoblast
European Journal of Clinical Pharmacology, 2012Bisphosphonates are synthetic analogues of pyrophosphate usually used in treating bone disorders such as osteoporosis, Paget's disease, fibrous dysplasia, hypercalcemia of malignancy, and inflammation-related bone loss. Though therapeutic effects of bisphosphonates depend primarily on their inhibitory effect on osteoclasts, increasing attention is ...
Maruotti N +3 more
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Osteoblasts and collagen orientation
Cell and Tissue Research, 1975Bone was removed from the calvaria of anaesthetized 70 g rats or freshly killed young monkeys and the fibrous periosteum dissected off the inner, formative surface under 0.15 M cacodylate buffer. The bone and undisturbed osteoblasts were fixed in 3% glutaraldehyde in the same buffer for 24 to 48 hours, critical point dried and coated with evaporated ...
S J, Jones, A, Boyde, J B, Pawley
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Advances in the osteoblast lineage
Biochemistry and Cell Biology, 1998Osteoblasts are the skeletal cells responsible for synthesis, deposition and mineralization of the extracellular matrix of bone. By mechanisms that are only beginning to be understood, stem and primitive osteoprogenitors and related mesenchymal precursors arise in the embryo and at least some appear to persist in the adult organism, where they ...
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Osteoblast function in myeloma
Bone, 2011Multiple myeloma (MM) is the most frequent cancer to involve the skeleton and results in purely osteolytic lesions that rarely heal. MM bone disease is responsible for some of the most devastating complications of MM. The marrow microenvironment plays a key role in MM bone disease as well as in the initiation, expansion and chemoresistance of MM cells.
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