Results 111 to 120 of about 81,269 (285)

Serum markers of bone fragility in type-2 diabetes mellitus [PDF]

, 2019
Patients with type-2 diabetes mellitus (T2DM) have normal or increased bone mineral density (BMD) but despite that, they are characterized by an increased hip and vertebral fracture risk that involves the alteration of bone quality and not the reduction ...
Dănciulescu Miulescu, Rucsandra, Guja, Loreta, Ochiana, Lavinia Claudia, Ungurianu, Anca, Șeremet, Oana Cristina, Ștefănescu, Emil   +5 more
core   +1 more source

Disease Progression Mediated by Egr-1 Associated Signaling in Response to Oxidative Stress [PDF]

, 2012
When cellular reducing enzymes fail to shield the cell from increased amounts of reactive oxygen species (ROS), oxidative stress arises. The redox state is misbalanced, DNA and proteins are damaged and cellular transcription networks are activated.
Abdulkadir, Abdulkadir, Aggeli, Arsenian, Banks, Baron, Bedadala, Bedard, Bjelakovic, Bjelakovic, Bonventre, Brand, Calogero, Cao, Cao, Chang, Chen, Christy, Christy, Cramer, Datta, Dixit, Dixit, Dyson, Dyson, Eidelman, Elisabeth Deindl, Eto, Eto, Fahmy, Fahmy, Feldman, Forsberg, Förstermann, Gao, Gashler, Hallahan, Halliwell, Harja, Harman, Harrison, Hasan, Hasan, Hebert, Heo, Hill, Hirata, Huang, Irani, Iyoda, Izumi, Judith-Irina Pagel, Katsarou, Kawamura, Khachigian, Khachigian, Konishi, Lee, Liao, Lim, Lukac, Marais, Meira, Nishi, Nose, Nose, Nozik-Grayck, Ohba, Ouellette, Pagel, Paron, Pavletich, Peskin, Pines, Preston, Radisky, Sakamoto, Sattler, Schwachtgen, Sies, Sies, Stuart, Sudenga, Tell, Tell, Tell, Tell, Terashima, Treisman, Tsai-Morris, Vickers, Vivekananthan, Wang, Whitmarsh, Yan, Yan, Yang, Yang, Ye, Yu   +99 more
core   +2 more sources

Pelvic morphology and body size in relation to the preauricular sulcus: Evidence from medieval to modern Iberia

The Anatomical Record, EarlyView.
Abstract The preauricular sulcus has long been debated as a pelvic feature variably attributed to obstetric stress, ligamentous traction, and broader biomechanical processes. To clarify its determinants, we analyzed 409 adult individuals from three archeological and one early modern skeletal collection from the Iberian Peninsula, integrating graded ...
Rebeca García‐González, Julia Muñoz‐Guarinos, Nico Cirotto, Sonia Díaz‐Navarro, Laura Rodríguez, José Miguel Carretero   +5 more
wiley   +1 more source

Periodontitis and metabolic diseases (diabetes and obesity): Tackling multimorbidity

Periodontology 2000, EarlyView., 2023
Abstract Noncommunicable diseases (NCDs) are multifactorial, long‐term, chronic conditions that represent a burden to health‐care systems worldwide as they can only be controlled rather than cured; hence, they require long‐term care. With the exponential increase in NCDs, the occurrence of individuals presenting with more than one chronic disease is ...
Crystal Marruganti, Jean E. Suvan, Francesco D'Aiuto   +2 more
wiley   +1 more source

EMD273316 & EMD95833, type 4 phosphodiesterase inhibitors, stimulate fibroblastic-colony formation by bone marrow cells via direct inhibition of PDE4 and the induction of endogenous prostaglandin synthesis [PDF]

, 2004
BACKGROUND: Type 4 phosphodiesterase (PDE4) inhibitors have been shown to stimulate bone formation in vivo and to stimulate osteoblastic differentiation in vitro.
Beier, Norbert, Fittschen, Claus, Scutt, Andrew   +2 more
core   +2 more sources

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

Surface guidance of stem cell behavior: Chemically tailored co-presentation of integrin-binding peptides stimulates osteogenic differentiation in vitro and bone formation in vivo [PDF]

, 2016
Surface modification stands out as a versatile technique to create instructive biomaterials that are able to actively direct stem cell fate. Chemical functionalization of titanium has been used in this work to stimulate the differentiation of human ...
Dashnyam, Khandmaa, Fraioli, Roberta, Gil Mur, Francisco Javier, Ginebra Molins, Maria Pau, Kim, Hae-Won, Kim, Joong-Hyun, Manero Planella, José María, Mas Moruno, Carlos, Pérez Antoñanzas, Román   +8 more
core   +2 more sources

Exosome as bioactive nanovesicle for diagnostic and therapeutic applications in periodontitis

BMEMat, EarlyView.
This review introduces the mechanism that exosomes participate in the pathogenesis of periodontitis and their potential as biomarkers for early diagnosis and summarizes the application of cell‐ or plant‐derived exosomes or engineered exosomes in periodontitis or periodontal regeneration while proposing the perspective of translational application of ...
Yu Wang, Yuchen Li, Yunfan Zhang, Chenshuang Li, Yifan Lin, Si Chen, Bing Han   +6 more
wiley   +1 more source

Targeting self-renewal pathways in myeloid malignancies [PDF]

, 2013
A fundamental property of hematopoietic stem cells (HSCs) is the ability to self-renew. This is a complex process involving multiple signal transduction cascades which control the fine balance between self-renewal and differentiation through ...
Copland, M., Sands, W.A., Wheadon, H.
core   +2 more sources

2D copper nanozyme patches facilitate bone regeneration via interfacial modulation of osteoclast‐osteoblast dynamics

BMEMat, EarlyView.
This study develops a nano‐enzyme patch (ezPatch) targeting bone interfaces. Utilizing ligand‐to‐metal charge transfer (LMCT) catalysis and bone‐targeting ligands on copper nanosheets, ezPatch simultaneously scavenges reactive oxygen species (ROS) and generates oxygen in situ at bone‐losing sites.
Yi Chen, Haoyue Hu, Danyang Wang, Ying Wang, Zhibang Li, Xiaoyi Liu, Yandi Zhang, Junkun Feng, Weiwei Zhao, Kai Li, Qi‐Zhi Zhong, Shaohua Ge, Jianhua Li   +12 more
wiley   +1 more source