Results 221 to 230 of about 82,535 (276)

Matrix mineralization controls gene expression in osteoblastic cells. [PDF]

Exp Cell Res, 2018
Wischmann J, Lenze F, Thiel A, Bookbinder S, Querido W, Schmidt O, Burgkart R, von Eisenhart-Rothe R, Richter GHS, Pleshko N, Mayer-Kuckuk P.   +10 more
europepmc   +1 more source

HSD17B7 Counters Bone Loss in Estrogen Deficiency via Estrogen Receptor Stabilization and Mediates the Effect of Raloxifene

MedComm, Volume 7, Issue 2, February 2026.
In this study, we identified a previously unrecognized function of HSD17B7 as an ERα‐binding protein that serves as a coactivator to influence trabecular bone mass in estrogen deficiency. Specifically, deleting HSD17B7 in myeloid cells enhanced the number of osteoclasts and decreased trabecular bone mass post‐OVX, compared with control OVX, mirroring ...
Junyue Zhang, Yiping Song, Jeong‐Hyun Koo, Si Chen, Kyu Yun Jang, Sun‐Jung Yoon, Jung Ryul Kim, Young Jae Moon   +7 more
wiley   +1 more source

Aging of the Hematopoietic System: Mechanisms, Consequences, and Systemic Interactions

Aging Cell, Volume 25, Issue 2, February 2026.
Hematopoietic aging arises from intrinsic stem‐cell decline and bone‐marrow niche dysfunction, leading to myeloid skewing, immunosenescence, and clonal hematopoiesis. These changes drive systemic inflammation and multi‐organ disease, which in turn further disrupt the bone‐marrow niche and hematopoietic stem cell (HSC) function, creating a vicious cycle
Masashi Miyawaki, Seiji Hashimoto, Sumito Ogawa, Yoshitaka Kase   +3 more
wiley   +1 more source

Adhesion and Proliferation of Osteoblastic Cells on Hydroxyapatite-dispersed Ti-based Composite Plate. [PDF]

In Vivo, 2019
Kobayashi M, Nihonmatsu S, Okawara T, Onuki H, Sakagami H, Nakajima H, Takeishi H, Shimada J.   +7 more
europepmc   +1 more source

Periodic Therapeutic Phlebotomy Mitigates Systemic Aging Phenotypes by Promoting Bone Marrow Function

Aging Cell, Volume 25, Issue 2, February 2026.
In D‐galactose‐induced aging model, periodic therapeutic phlebotomy exerts significant and comprehensive anti‐aging effects by inducing bone marrow microenvironment restoration, which rebalances hematopoiesis to restore peripheral blood function and ameliorate systemic aging phenotypes.
Ji‐Ru Cai, Jian Zhang, Yue‐Xin Ning, Jing Zhang, Tian‐Ce Xu, Mei‐Chen Liu, Ke‐Xin Wang, Hui‐Sheng Chen   +7 more
wiley   +1 more source

Effect of low power laser in biomodulation of cultured osteoblastic cells of Wistar rats1. [PDF]

Acta Cir Bras, 2019
Morsoleto MJMDS, Sella V, Machado P, Bomfim FD, Fernandes MH, Morgado F, Lopes Filho GJ, Plapler H.   +7 more
europepmc   +1 more source

Washington University Medical Alumni Quarterly, April 1950 [PDF]

, 1950

core   +1 more source

Stromal Defense Against Cancer: An Unprecedented Mechanism Limiting Cancer Invasion Into the Bone

Cancer Science, Volume 117, Issue 2, Page 308-315, February 2026.
The roles of nonimmune systems in tumor regulation remain largely undefined. This article introduces a new concept, “stromal defense against cancer (SDAC),” which is based on recent findings that the periosteum actively responds to tumor proximity and physically impedes tumor invasion into bone.
Masayuki Tsukasaki, Hiroshi Takayanagi
wiley   +1 more source

A metabolic comparison of GIPR agonism versus GIPR antagonism in male mice

Diabetes, Obesity and Metabolism, Volume 28, Issue 2, Page 1160-1167, February 2026.
Abstract Aims Targeting the glucose dependent insulinotropic polypeptide receptor (GIPR) is of growing interest for treating type 2 diabetes and obesity, though the optimal approach remains unclear. Both GIPR agonism and antagonism, respectively, incorporated into drugs like tirzepatide and maridebart cafraglutide, have paradoxically both shown ...
Iona Davies, Alexandra Turland, Hanh Duyen Tran, Carissa Wong, Olivier Cahn, Cecilia Dunsterville, Yichang Sun, Yilin Xiao, Kevin G. Murphy, Stephen R. Bloom, Ben Jones, Tricia M. M. Tan   +11 more
wiley   +1 more source

Effect of metformin on inflammation and bone damage in a rat model of medication‐related osteonecrosis of the jaw

European Journal of Oral Sciences, Volume 134, Issue 1, February 2026.
Abstract This study investigated how chronic metformin administration modulates the cellular profile and inflammatory markers in a zoledronic acid‐based rat model of medication‐related osteonecrosis of the jaw (MRONJ). Male Wistar rats were allocated to different treatments: (i) naïve, (ii) MRONJ (zoledronic acid, 0.2 mg/kg, i.v.
Liviane Maria Alves Rabelo, Mariana Vasconcelos Guimarães, Aurilene Gomes Cajado, José Vitor Mota Lemos, Felipe Domingos de Sousa, Nylane Maria Nunes Alencar, Vilma de Lima, Paulo Goberlânio de Barros Silva, Ana Paula Negreiros Nunes Alves, Deysi Viviana Tenazoa Wong, Roberto César Pereira Lima‐Júnior   +10 more
wiley   +1 more source