Results 291 to 300 of about 130,158 (334)

Developments of Thermosensitive Hydrogel for Maxillofacial Bone Regeneration

Small Science, EarlyView.
Thermosensitive hydrogel with seed cells and growth factors presents a new method for bone regeneration, changing states with temperature and offering fluidity, injectability, and controlled drug release. This article reviews thermosensitive hydrogel's role in angiogenesis, neurogenesis, and osteogenesis in maxillofacial bone regeneration and discusses
Qinrou Zhang, Ying Wu, Jialiang Dai, Zihan Jia, Minjia Zhu, Xinyi Li, Le Xiao, Jingyi Li, Zixiang Dai, Yuxing Bai, Jibin Song, Ke Zhang   +11 more
wiley   +1 more source

CAV-1 regulates osteocyte communication with osteoclast and osteoblast precursors. [PDF]

Sci Rep
Pizarro-Gomez J, Tirado-Cabrera I, Heredero-Jimenez S, Martin-Guerrero E, Portal-Nuñez S, Alonso V, Ardura JA, Gortazar A.   +7 more
europepmc   +1 more source

Nanozymes in Reactive Oxygen Species‐Dependent Diseases: From Design and Preclinical Studies to Clinical Translation Prospects

Small Structures, EarlyView.
Nanozymes emerge as promising therapeutic agents for reactive oxygen species (ROS)‐dependent diseases, offering advantages over traditional biocatalysts through enhanced stability, tunability, and targeting capabilities. This review explores their mechanisms, design strategies, and clinical progress, emphasizing precision medicine potential.
Lihong Zhou, Jingyu Yan, Chenying Cui, Yurong Xu, Kaifang Zhang, Meijun Du, Zhuowei Zhang, Xiuping Wu, Bing Li   +8 more
wiley   +1 more source

Congenital lipodystrophy induces severe osteosclerosis [PDF]

, 2019
Brestoff, Jonathan R, Brodt, Michael D, Craft, Clarissa S, Harris, Carles A, Migotsky, Nicole, Rohatgi, Nidhi, Scheller, Erica L, Silva, Matthew J, Teitelbaum, Steven L, Zhang, Yan, Zou, Wei   +10 more
core   +1 more source

Nanotechnology and cell death: Revolutionizing disease treatment with nanoparticle strategies

VIEW, EarlyView.
Traditional disease treatments often face issues such as poor drug targeting and significant side effects, with many complex diseases lacking effective therapies. Our research utilizes tiny nanomaterials to treat diseases by regulating natural cell death processes, improving the immune environment, etc., enabling drugs to act more precisely.
Yiwen Wan, Wangzheqi Zhang, Yan Liao, Chenglong Zhu, Xiaojing Guo, Zui Zou, Mi Li   +6 more
wiley   +1 more source

Arachidonic Acid Metabolism Down-Regulation-Mediated Tumor Necrosis Factor Signaling Contributes to Cutaneous Fibrosis and Skull Hyperplasia in Goldfish Hoods. [PDF]

Research (Wash D C)
Li LL, Xu QL, Yi WJ, Ma DD, Jin H, Fu DZ, Yang XL, Wang Y, Li Z, Wang ZW, Li XY, Lu M, Zhang XJ, Zhou L, Gui JF, Yu P.   +15 more
europepmc   +1 more source

Skeletal Maturity and Age‐Related Changes in Immune Cells and Circulatory Factors Impair Large‐Scale Bone Regeneration

Aging Cell, EarlyView.
Although the ribs are the only human bones capable of regenerating large‐scale defects, this remarkable ability declines with skeletal maturity and age. Here, we reproduce skeletal maturity and age‐related phenotypic changes in a mouse model of rib resection.
Luciana Yamamoto de Almeida, Catharine Dietrich, Ashleigh S. Hanner, Katelyn M. McTighe, Daniel Martin, NIDCD/NIDCR Genomics and Computational Biology Core, Todd Fairbanks, Thomas M. Link, John M. Le, Natasha Curry, Priyam Jani, Xin Gao, Wenli Yu, Francesca V. Mariani, Olivier Duverger, Janice S. Lee   +15 more
wiley   +1 more source

Exogenous activation of the adhesion GPCR ADGRD1/GPR133 protects against bone loss by negatively regulating osteoclastogenesis. [PDF]

Sci Adv
He L, Zhang Q, You Y, Sun P, Xu Z, Li R, Wang F, Zhang S, He J, Shen J, Zhao L, Hong Y, Li Y, Liu M, Sun JP, Wang N, Sun Y, Yang H, Luo J.   +18 more
europepmc   +1 more source

Iron dysregulation, ferroptosis, and oxidative stress in diabetic osteoporosis: Mechanisms, bone metabolism disruption, and therapeutic strategies. [PDF]

World J Diabetes
Wang YB, Li ZP, Wang P, Wang RB, Ruan YH, Shi Z, Li HY, Sun JK, Mi Y, Li CJ, Zheng PY, Zhang CJ.   +11 more
europepmc   +1 more source

Phosphodiesterase 3 inhibitors boost bone outgrowth

British Journal of Pharmacology, EarlyView.
Background and Purpose C‐type natriuretic peptide (CNP) stimulates skeletal growth by acting on the growth plates of long bones, and a CNP variant is clinically used for achondroplasia treatment. We previously reported that CNP stimulates the autonomic Ca2+ influx mediated by TRPM7 channels in growth plate chondrocytes to facilitate extracellular ...
Takaaki Kawabe, Atsuhiko Ichimura, Tomoki Yasue, Jianhong Li, Haruki Ishikawa, Ga Eun Kim, Hiroki Nagatomo, Naoto Minamino, Yohei Ueda, Hiromu Ito, Miyuki Nishi, Hiroshi Takeshima   +11 more
wiley   +1 more source