Results 321 to 330 of about 130,158 (334)
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Generation of Osteoclasts In Vitro, and Assay of Osteoclast Activity
2007Osteoclasts are bone-resorbing multinucleated cells derived from the monocyte-macrophage lineage. The authors have developed a mouse marrow culture system and a coculture system of mouse osteoblasts and hemopoietic cells, in which osteoclasts are formed in response to various osteotropic factors such as 1alpha,25-dihydroxyvitamin D3, parathyroid ...
Nobuyuki Udagawa +3 more
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Long bone osteoclasts display an augmented osteoclast phenotype compared to calvarial osteoclasts
Biochemical and Biophysical Research Communications, 2010Osteoclasts are multinucleated cells specialized in degrading bone and characterized by high expression of the enzymes tartrate-resistant acid phosphatase (TRAP) and cathepsin K (CtsK). Recent studies show that osteoclasts exhibit phenotypic differences depending on their anatomical site of action.
Göran Andersson +2 more
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1998
Publisher Summary This chapter discusses the osteoclast cytoskeleton. Eukaryotic cells contain three major classes of cytoskeletal fibers: 7 nm diameter actin microfilaments, 24 nm diamenter microtubules (MTs), and 10 nm diameter intermediate filaments. All of these fibers are formed by finely regulated polymerization of protein subunits.
ZAMBONIN ZALLONE A +2 more
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Publisher Summary This chapter discusses the osteoclast cytoskeleton. Eukaryotic cells contain three major classes of cytoskeletal fibers: 7 nm diameter actin microfilaments, 24 nm diamenter microtubules (MTs), and 10 nm diameter intermediate filaments. All of these fibers are formed by finely regulated polymerization of protein subunits.
ZAMBONIN ZALLONE A +2 more
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Osteoblasts and Osteoclasts [PDF]
, 2000 The skeleton is a highly specialized and dynamic organ that undergoes continuous regeneration. Its functions are to maintain the shape of the body, protect vital organs, serve as a scaffold for the muscles, allowing their contractions to be translated into bodily movements, resist mechanical load during locomotion and weight bearing, and provide a ...
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Microscopy Research and Technique, 2003
AbstractOsteoclasts are the only cells capable of resorbing mineralised bone, dentine and cartilage. Osteoclasts act in close concert with bone forming osteoblasts to model the skeleton during embryogenesis and to remodel it during later life. A number of inherited human conditions are known that are primarily caused by a defect in osteoclasts. Most of
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AbstractOsteoclasts are the only cells capable of resorbing mineralised bone, dentine and cartilage. Osteoclasts act in close concert with bone forming osteoblasts to model the skeleton during embryogenesis and to remodel it during later life. A number of inherited human conditions are known that are primarily caused by a defect in osteoclasts. Most of
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Isolation and Generation of Osteoclasts
2019This chapter describes the isolation, culture, and staining of osteoclasts. The key advantages of this assay are that it allows direct measurement of osteoclast number, bone resorption, as well as yielding good quantities of osteoclasts at defined stages of formation for molecular analysis.
Nadia Rucci, Alberta Zallone, Anna Teti
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Osteoclast receptors and signaling
Archives of Biochemistry and Biophysics, 2008Osteoclasts are bone-resorbing cells derived from hematopoietic precursors of the monocyte-macrophage lineage. Besides the well known Receptor Activator of Nuclear factor-kappaB (RANK), RANK ligand and osteoprotegerin axis, a variety of factors tightly regulate osteoclast formation, adhesion, polarization, motility, resorbing activity and life span ...
Del Fattore A +2 more
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Journal of Cellular Biochemistry, 1994
AbstractIn biological research, new ideas arise and quickly spread to encompass the entire field. Thus, the evolution of molecular biology has significantly changed our methods of approaching our research. A similar far‐reaching finding has been the advent of radical reactions into biology.
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AbstractIn biological research, new ideas arise and quickly spread to encompass the entire field. Thus, the evolution of molecular biology has significantly changed our methods of approaching our research. A similar far‐reaching finding has been the advent of radical reactions into biology.
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Regulation of Differentiated Osteoclasts
Critical Reviews in Eukaryotic Gene Expression, 2000Osteoclasts respond to many factors, including endocrines, cytokines, cell-cell interactions, and cell-matrix contacts. For mature osteoclasts, the first level of control occurs through signaling that follows binding to an appropriate substrate. Mononuclear and multinucleate osteoclasts are activated when cell surface integrins, notably but not ...
C V, Gay, J A, Weber
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Bone Cells Required for Osteoclastic Resorption but Not for Osteoclastic Differentiation
Biochemical and Biophysical Research Communications, 1996It is generally considered that osteoblastic cells are essential for osteoclast formation. We tested the ability of hemopoietic tissue to differentiate osteoclastic characteristics in the absence of osteoblastic cells. We found that large numbers of calcitonin-receptor positive (CTRP) cells can be induced by prostaglandin E2 and 1,25(OH)2 vitamin D3 ...
A.C. Gallagher, T.J. Chambers, J. Owens
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