Results 321 to 330 of about 182,622 (382)

Regulatory Effect and Mechanism of Tanshinone I on Cell Apoptosis in Steroid‐Induced Osteonecrosis of the Femoral Head

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Steroid‐induced osteonecrosis of the femoral head (SIONFH) is a debilitating orthopedic condition. This study investigated the mechanism of Tanshinone I (TsI) in SIONFH modulating apoptosis in SIONFH via the PI3K/AKT/mTOR pathway. A SIONFH rat model was treated with TsI and a PI3K activator. Bone mineral density (BMD), bone volume/total volume
Qing Su, Jia Chen
wiley   +1 more source

Fracture-Induced Immunological Cascades Trigger Rapid Systemic Bone Loss via Osteocyte-Regulated Osteoclastogenesis. [PDF]

Immunotargets Ther
Sun L, Kuang S, Li Y, Wang G, Sun J, Zhou F, Zhang C.   +6 more
europepmc   +1 more source

Impact of Denosumab Adherence on Renal Function and Mortality Rates in Type 2 Diabetes Patients With Osteoporosis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Type 2 diabetes mellitus (T2DM) is associated with an increased risk of osteoporosis and fractures, and denosumab, a non‐kidney‐excreted antiresorptive medication, represents a viable alternative to bisphosphonates for osteoporosis treatment in patients with T2DM. This study aimed to investigate the association among denosumab adherence, renal
Yu‐Chuan Chang, Jian‐Chih Chen, Sung‐Yen Lin, Kun‐Der Lin, Pei‐Shan Ho, Chung‐Hwan Chen, Yin‐Chih Fu, Tien‐Ching Lee   +7 more
wiley   +1 more source

Immunosuppressive tumor microenvironment and advance in immunotherapy in melanoma bone metastasis. [PDF]

Front Immunol
Ma Y, Zhang L, Liu W.
europepmc   +1 more source

Sterol Metabolism in Ovariectomized Rats: Potential Roles of Campesterol and 4β‐Hydroxycholesterol in Osteoporosis

Lipids, EarlyView.
ABSTRACT Osteoporosis is characterized by low bone mass and microarchitectural deterioration of bone tissue. Lipid metabolism disorders may contribute to osteoporosis in postmenopausal women. Phytosterols and oxysterols (OC) are involved in lipid metabolism.
Wenzhao He, Sayuri Eguchi, Sen Wang, Yasutake Tanaka, Masao Sato   +4 more
wiley   +1 more source

Integrative Study of Dipsaci Radix and Phlomidis Radix: Nomenclature, Morphology, DNA-Based Authentication, and Comparative Effects on Osteoclastogenesis. [PDF]

Pharmaceuticals (Basel)
Song JH, Seo YS, Kim Y, Jeong S, Yang S, Choi G, Kim JS, Park I.   +7 more
europepmc   +1 more source

Novel Antioxidant and Antibacterial Injectable Hydrogels Incorporating Clove Oil‐Loaded Mesoporous Bioactive Glass Nanoparticles: A Promising Strategy for Enhanced Bone Regeneration

Macromolecular Bioscience, EarlyView.
A novel injectable hydrogel composed of alginate–gelatin–xanthan gum incorporating clove oil (CLV)‐loaded mesoporous bioactive glass nanoparticles is developed. The system demonstrates enhanced antioxidant and antibacterial activity, increased Young's modulus, and good injectability.
Andrada‐Ioana Damian‐Buda, Markus Lorke, Aldo R. Boccaccini, Irem Unalan   +3 more
wiley   +1 more source

SHP2 inhibition by SHP099 attenuates IL-6-driven osteoclastogenesis in growth plate injury. [PDF]

Front Immunol
Zhang Q, Li N, Dai ZZ, Liu XM, Ding J, Sha L, Li H.   +6 more
europepmc   +1 more source

Fabrication of Lithium/Strontium‐Releasing Smart Bioactive Glasses with Anti‐Inflammatory and Osteogenic Effects Tailored to Pathological Stages

Macromolecular Bioscience, EarlyView.
Bioactive glasses with controllable dual ion release capability are developed to aid bone regeneration. The bioactive glasses rapidly release lithium ions that exert an anti‐inflammatory effect, suppressing inflammation after bone injury. Simultaneously, the bioactive glasses slowly release strontium ions, which support bone formation by suppressing ...
Hirohiko Sakai, Jun‐Ichi Sasaki, Haruaki Kitagawa, Gabriela L. Abe, Tomoki Kohno, Naoya Funayama, Satoshi Imazato   +6 more
wiley   +1 more source

The Evolving Landscape of Immunotoxicity: Charting Mechanisms and Future Strategies for Immune Checkpoint Inhibitor Adverse Events

Med Research, EarlyView.
ABSTRACT The use of immune checkpoint inhibitors (ICIs) has significantly improved the efficacy of cancer therapy, but their associated immune‐related adverse events (irAEs) can severely compromise treatment safety. This review systematically summarizes the core mechanisms underlying irAEs, which include multi‐organ damage resulting from T‐cell ...
Anqi Lin, Keyin Zheng, Aimin Jiang, Xufeng Huang, Qi Wang, András Hajdu, Zhengrui Li, Jian Zhang, Peng Luo   +8 more
wiley   +1 more source