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Bone Cells Required for Osteoclastic Resorption but Not for Osteoclastic Differentiation
Biochemical and Biophysical Research Communications, 1996It is generally considered that osteoblastic cells are essential for osteoclast formation. We tested the ability of hemopoietic tissue to differentiate osteoclastic characteristics in the absence of osteoblastic cells. We found that large numbers of calcitonin-receptor positive (CTRP) cells can be induced by prostaglandin E2 and 1,25(OH)2 vitamin D3 ...
A.C. Gallagher, T.J. Chambers, J. Owens
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2013
Osteoclasts are the principal, perhaps only, cells capable of destroying bone. They are highly motile cells, usually multinucleated, and of hemopoietic origin. Osteoclasts excavate characteristic pits and trails on bone by pumping protons to solubilize the mineral component (hydroxyapatite) and secreting cathepsin K, an enzyme that partly degrades the ...
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Osteoclasts are the principal, perhaps only, cells capable of destroying bone. They are highly motile cells, usually multinucleated, and of hemopoietic origin. Osteoclasts excavate characteristic pits and trails on bone by pumping protons to solubilize the mineral component (hydroxyapatite) and secreting cathepsin K, an enzyme that partly degrades the ...
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Osteoclast differentiation and activation
Nature, 2003W. J. Boyle, W. S. Simonet, D. Lacey
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2011
Publisher Summary One of the integral cell types contributes significantly to regulation of bone mass; osteoblasts, of mesenchymal origin, are transducers of numerous endocrine and paracrine signals. Separately they secrete and calcify the unique bone matrix, which is degraded by myeloid derived osteoclasts.
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Publisher Summary One of the integral cell types contributes significantly to regulation of bone mass; osteoblasts, of mesenchymal origin, are transducers of numerous endocrine and paracrine signals. Separately they secrete and calcify the unique bone matrix, which is degraded by myeloid derived osteoclasts.
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Recent advances in osteoclast biology
Histochemistry and Cell Biology, 2018T. Ono, T. Nakashima
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Identification of a novel arthritis-associated osteoclast precursor macrophage regulated by FoxM1
Nature Immunology, 2019Tetsuo Hasegawa +14 more
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Genetic regulation of osteoclast development and function
Nature reviews genetics, 2003S. Teitelbaum, F. Ross
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LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption
Nature Network Boston, 2016Jian Luo +18 more
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The molecular understanding of osteoclast differentiation.
Bone, 2007M. Asagiri, H. Takayanagi
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