Results 211 to 220 of about 109,289 (351)

Expert Perspective: How, When, and Why to Potentially Stop Antiresorptive Drugs in Osteoporosis

Arthritis &Rheumatology, EarlyView.
Osteoporosis is a chronic disease, and antiresorptive treatments are often continued for many years. Despite their established efficacy in reducing fracture risk, the most commonly used antiresorptive treatments, bisphosphonates and denosumab, have short‐ and long‐term risks that, coupled with their benefits and other unique characteristics, influence ...
Giovanni Adami, Kenneth G. Saag
wiley   +1 more source

A three-dimensional reconstruction of the ruffled border of osteoclasts.

, 1989
Takanori Domon, Minoru Wakita
openalex   +2 more sources

Metabolic reprogramming in osteoclasts

Seminars in Immunopathology, 2019
Kyung-Hyun Park-Min
semanticscholar   +1 more source

Pharmacology and safety of TAS5315, a Bruton tyrosine kinase inhibitor, in healthy volunteers: First‐in‐human, randomized, ascending‐dose studies

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim TAS5315 is a Bruton tyrosine kinase (Btk) inhibitor in development for autoimmune and allergic diseases, including rheumatoid arthritis (RA) and chronic spontaneous urticaria (CSU). Two clinical studies evaluated the pharmacology and safety of single and multiple oral doses of TAS5315.
Yuji Kumagai, Tomoe Fujita, Mika Maeda, Akiko Yamamoto, Hideki Amano   +4 more
wiley   +1 more source

Control of Cytosolic Free Calcium in Rat and Chicken Osteoclasts

, 1989
Antonio Malgaroli, Jacopo Meldolesi, Alberta Zallone, Anna Teti   +3 more
openalex   +1 more source

Systemic T‐cell and local macrophage interactions mediate granule size‐dependent biological hydroxyapatite foreign body reaction

BMEMat, EarlyView.
This study expanded our understanding of the size effect of biological hydroxyapatite (BHA) granules from a biological perspective rather than physical defect accommodation. Besides, we proposed the multi‐level structure of commercially available BHA granules based on their microstructure and provided a biological mechanism for the classification of ...
Yixiong Lin, Yang Zou, Jieting Yang, Zongpu Han, Xinyu Guo, Xiaomeng Gao, Jieyun Xu, Zhuohong Gong, Ruizhi Li, Zhipeng Li, Baoxin Huang, Yin Xiao, Feilong Deng, Zetao Chen   +13 more
wiley   +1 more source

Deciphering the skeletal interoceptive circuitry to control bone homeostasis

BMEMat, EarlyView.
This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu, Jiusi Guo, Zhen Chen, Fengwei Zhang, Billy Kwok Chong Chow, Zhuofan Chen, Kelvin Wai‐Kwok Yeung, Wei Qiao   +7 more
wiley   +1 more source

Osteoclast enlargement in endstage renal disease

, 1985
Michael Kaye, Steven W. Zucker, Yvan G. Leclerc, Sarah Prichard, Anthony B. Hodsman, P. E. Barre   +5 more
openalex   +1 more source

Characterization of Regulatory Extracellular Vesicles from Osteoclasts

Journal of dentistry research, 2016
N. Huynh, L. VonMoss, D. Smith, I. Rahman, M. F. Felemban, J. Zuo, W. Rody, K. Mchugh, L. Holliday   +8 more
semanticscholar   +1 more source

Optimizing biophysical properties of cellular niches to enhance stem cell‐derived extracellular vesicle function in musculoskeletal regeneration

BMEMat, EarlyView.
Extracellular vesicles (EVs) derived from stem cells show promise for applications in regenerative medicine, but their scalability and yield remain challenges. This review explores the approaches for biophysical modulations within cell niches on EV properties, discusses the current clinical application of EVs, and provides an outlook on the existing ...
Yang Xu, Chung Yin Matthew Cheung, Liling Liu, Hoi Pan Harry Cheung, Kam Yu Tam, Dai Fei Elmer Ker, Sarah H. Cartmell, Chuanbin Mao, Zhiyong Zhang, Dan Michelle Wang   +9 more
wiley   +1 more source