Results 201 to 210 of about 134,929 (355)

Histiocytosis development and clinical variation through the lens of genomics

The Journal of Pathology, EarlyView.
Abstract Histiocytic neoplasms are rare haematologic diseases characterised by clonal expansions of cells with a monocyte, macrophage or dendritic cell phenotype. Their clinical manifestations are diverse, ranging from indolent lesions to aggressive systemic disease.
Paul G Kemps, Astrid GS van Halteren, Tom van Wezel, Pancras CW Hogendoorn   +3 more
wiley   +1 more source

Osteoclast Heterogeneity in Osteoarthritis: From Single-Cell Microenvironments to Program-Specific Therapeutic Opportunities. [PDF]

Int J Mol Sci
Tang T, Zhang P, Lin Z, Tang ZH, Chen D.
europepmc   +1 more source

Ineffectiveness of immune checkpoint inhibitors in prostate cancer: is it just a question of ‘‐mabs’?

The Journal of Pathology, EarlyView.
Abstract Prostate cancer (PCa) is the second most common type of neoplasm, currently treated with a variety of therapeutic agents. Although advances in treatment over the past decade have improved overall survival, patients with advanced PCa eventually progress from hormone‐sensitive PCa to metastatic castration‐resistant PCa.
Giuseppe Schepisi, Irene Torresan, Emilio Francesco Giunta, Sara Bleve, Nicole Brighi, Elisa Tassinari, Sofia Zanuccoli, Maria Concetta Cursano, Cristian Lolli   +8 more
wiley   +1 more source

cGAS-STING pathway mediation in osteoclast function and bone fracture healing. [PDF]

Front Immunol
Zheng M, Zhao L, Nian S, Wei Q, Zhou P, Tang H.   +5 more
europepmc   +1 more source

Disrupted joint clock is associated with rhythmic expression of bone destruction factors in collagen‐induced arthritis

Rheumatology &Autoimmunity, EarlyView.
Schematic Summary of Circadian Dysregulation in Arthritic Joints. This graphical abstract illustrates the key circadian disruptions observed in the collagen‑induced arthritis (CIA) model. The diagram depicts three main findings: (1) Nocturnal elevations in pro‑inflammatory cytokines (TNF‑α, IL‑6, IL‑17, IL‑1β, MIF) and bone‑destructive factors (DKK‑1 ...
Xiaogang Zhang, Mingming Zhang, Zhiqiang Wang, Jie Bai, Xing Feng, Yajing Wang, Zhenbin Li, Dongbao Zhao   +7 more
wiley   +1 more source

SphK1/mitophagy axis in cementocytes drives orthodontic root resorption via mitochondrial transfer to osteoclasts. [PDF]

Bone Res
Wang H, Chen S, Chen S, Duan C, Zhu L, Lin H, Zou S, Li Y, Duan P.   +8 more
europepmc   +1 more source

Staging concept for aging management: Definition, mechanism, and coping strategies

VIEW, EarlyView.
We divided the overall aging stage into “pre‐aging”, “aging compensation”, and “aging disability”. For each stage, we delineate the clinical presentations, biological phenomena, theoretical underpinnings, and key management priorities. Abstract Aging, as a gradual and largely irreversible biological process, characterized by declining organismal ...
Zhonghan Wang, Shixian Liu, Shangyu Du, Xiangran Cui, Bo Chao, Minglei Liu, Minfei Wu   +6 more
wiley   +1 more source

5-methoxyresorcinol mitigates postmenopausal osteoporosis through regulation of the PI3K-AKT-GSK3β signaling pathway and ROS homeostasis. [PDF]

Front Pharmacol
Yang M, Li R, Wang H, Geng Y, Yv Z, Qiao J, Li Y.   +6 more
europepmc   +1 more source

Estrogen Prevents Bone Loss via Estrogen Receptor α and Induction of Fas Ligand in Osteoclasts

, 2007
Takashi Nakamura, Yuuki Imai, Yuuki Imai, Takahiro Matsumoto, Shingo Sato, Kazusane Takeuchi, K. Igarashi, Y. Harada, Y. Azuma, A. Krust, Yoko Yamamoto, H. Nishina, S. Takeda, H. Takayanagi, D. Metzger, J. Kanno, K. Takaoka, T. Martin, P. Chambon, S. Kato   +19 more
semanticscholar   +1 more source

Progress in bone tissue engineering biomaterials: Development, challenges, and prospects

VIEW, EarlyView.
Scheme 1 Application of biomaterials in immunomodulation during bone tissue engineering. Abstract Bone defect repair remains a major clinical challenge in orthopedics. Over 2 million cases caused by trauma, tumors, and other factors occur annually, with large‐scale defects posing a particular bottleneck due to limited self‐healing capacity.
Yuanbin Zhang, Junlei Chai, Quanwei Ding, Luping Liu, Kejie Zhang, Jie Lin, Jianhua Zhang, Youju Huang   +7 more
wiley   +1 more source