Results 201 to 210 of about 88,889 (259)

Brain calcification‐associated JAM2 pathogenic mutations impair JAM2–JAM3 tight junction structure and the blood–brain barrier integrity

Brain Pathology, EarlyView.
Pathogenic JAM2 mutations disrupt the JAM2–JAM3 heterodimer structure and tight junction integrity, leading to blood–brain barrier breakdown. Consequently, Jam2‐deficient mice develop prominent midbrain calcification and significant motor impairments, identifying the JAM2–JAM3 interaction as a vital target for primary brain calcification therapeutics ...
Dehao Yang, Lebo Wang, Chenxin Ying, Yihua Shi, Yuru Guo, Haotian Wang, Xinhui Chen, Yaoting Wang, Xinchen Wang, Fan Zhang, Xiaosheng Zheng, Yiling Chen, Haoyu Wang, Zhiru Lin, Jiaxiang Li, Haibin Xia, Jiawen Chen, Feng Fu, Bo Wang, Sheng Wu, Ping Wang, Fei Xie, Zhidong Cen, Zhiping Wang, Wei Luo   +24 more
wiley   +1 more source

The cortical microenvironment drives early immune organization and controls early osteoclastogenesis in bone healing. [PDF]

Nat Commun
Noom A, Oktay HZ, Morgan DM, Kroh S, Kasapi A, Ellinghaus A, Kochan M, Bolaji O, Uecker R, Günther R, Bianchi MP, Bucher CH, Hildebrandt A, Haas S, Schmidt-Bleek K, Triantafyllopoulou A, Hauser AE, Sawitzki B, Duda GN.   +18 more
europepmc   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

TLR9-engineered photoresponsive biomimetic nanodecoys for targeted NETs clearance to mitigate periodontitis-associated bone resorption. [PDF]

Int J Oral Sci
Liu S, Liu Y, Chen Y, Jiao Y, Zhao R, Wang Y, Zhang J, Zhang S, Liu Y, Guo L.   +9 more
europepmc   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

Nrf2 dynamically regulates RANKL-induced osteoclastogenesis and cathepsin K function. [PDF]

J Biol Chem
Speck-Hernandez CA, Furtado TCS, de Souza LY, da Silva KR, Lucena Silva GV, Gonzalez Osuna L, Publio GA, Schneider AH, Melo PH, Scalice-Chiari G, Alves-Filho JC, Cunha FQ, Cunha TM, Fukada SY.   +13 more
europepmc   +1 more source

Integrated Transcriptomics of Human and Canine Osteosarcoma Reveals Species Stemness and Trabectedin Sensitivity

Cancer Science, EarlyView.
Comprehensive comparative molecular framework for human and canine osteosarcomas. Integrated transcriptomic analyses establish a comprehensive comparative molecular framework for human and canine osteosarcomas. By defining species‐specific stemness architectures and drug response dynamics, our findings highlight the necessity of accounting for distinct
Kenta Kono, Yomogi Shiota, Ting‐Ting Shu, Hayato Shibahara, Daiki Kato, Takayuki Nakagawa, Seiji Ohtori, Tadashi Kondo   +7 more
wiley   +1 more source

Histone H3K18 lactylation: An exercise-induced epigenetic mechanism that inhibits osteoclast activity and protects against osteoporosis. [PDF]

J Orthop Translat
He Z, Wu Y, You Y, Li T, Liao Y, Chen J, Wang Y, Sheng Y, Zhao Y, Ye W, Yin M, Zhang P, Li J, Tang H, Lou J, Fu X, Yang X, Ji Y.   +17 more
europepmc   +1 more source

Teriparatide Topical Delivery Supports Osseointegration in Ovariectomized Rats Receiving Cafeteria Diet and Bisphosphonate: An In Vivo Experimental Study

Clinical Oral Implants Research, EarlyView.
ABSTRACT Background Postmenopausal osteoporosis associated with cafeteria diet and bisphosphonate therapy may impair peri‐implant bone repair. Therefore, strategies to enhance osseointegration are needed. Aim This study investigated whether teriparatide‐coated implant surfaces enhance osseointegration in a rodent model of estrogen deficiency (OVX) and ...
Ana Cláudia Ervolino da Silva, Fábio Roberto de Souza Batista, Jaqueline Suemi Hassumi, Naara Gabriela Monteiro, Marina Santos Fernandes, Luana Marotta Reis Vasconcellos, Gabriel Mulinari‐Santos, Reinhard Gruber, Paulo Noronha Lisboa‐Filho, Roberta Okamoto   +9 more
wiley   +1 more source