Results 181 to 190 of about 88,889 (259)

Oxidative Stress and Metabolic Reprogramming in Osteoclastogenesis: Molecular Mechanisms and Antioxidant Therapy for Bone Disorders. [PDF]

Antioxidants (Basel)
Alam MI, Farhana F, Khan TR, Sharmin F, Hurunnaher M, Katsuma Y, Sakai E, Sumita Y.   +7 more
europepmc   +1 more source

Phloretin Ameliorates Rheumatoid Arthritis by Suppressing HIF‐1α‐Dependent Angiogenesis and Modulating of the Autophagy–Apoptosis Balance

Phytotherapy Research, EarlyView.
ABSTRACT Phloretin (PHL) is an effective monomer component of Phellodendri Chinensis Cortex, Spica Prunellae, and fleshy fruits and exerts therapeutic effects on rheumatoid arthritis (RA). However, the underlying mechanism is yet to be elucidated. Following PHL treatment, therapeutic benefits were evaluated in a collagen‐induced arthritis (CIA) rat ...
Liang Han, Weiji Lin, Xin Ba, Mingjie Hu, Jiahui Yan, Zhe Chen, Kai Qin, Shenghao Tu, Pan Shen   +8 more
wiley   +1 more source

Modulation of Arachidonic Acid Metabolism by Pinoresinol Diglucoside Ameliorates Osteogenic Dysfunction via Coordinated NF‐κB Suppression and GSK3β/β‐Catenin Activation in Diabetic Osteoporosis

Phytotherapy Research, EarlyView.
ABSTRACT Diabetic osteoporosis (DOP) is characterized by chronic low‐grade inflammation and impaired bone formation. Pinoresinol diglucoside (PDG), a bioactive compound derived from Eucommia ulmoides Oliv., has shown therapeutic potential in metabolic bone disorders; however, its direct molecular targets and integrated mechanisms remain unclear.
Wenqi Jin, Yujing Tan, Lei Zhang, Weigeng She, Yunhang Chu, Xuenan Chen, Shuai Zhang, Liwei Sun   +7 more
wiley   +1 more source

C-type lectin receptors: bone remodeling and therapeutic potential. [PDF]

Bone Res
Kleim M, Bozec A, Weber M, Groetsch B.
europepmc   +1 more source

Calvarial Bone Channels and a Putative Craniomaxillary–Brain Interface in Central Nervous System Immunity

Med Research, EarlyView.
Ziwen Sheng, Yulong Zhang, Hao Wang, Wenyu Zhen, Youming Zhu, Haitao Wang, Hengguo Zhang   +6 more
wiley   +1 more source

Disrupted joint clock is associated with rhythmic expression of bone destruction factors in collagen‐induced arthritis

Rheumatology &Autoimmunity, EarlyView.
Schematic Summary of Circadian Dysregulation in Arthritic Joints. This graphical abstract illustrates the key circadian disruptions observed in the collagen‑induced arthritis (CIA) model. The diagram depicts three main findings: (1) Nocturnal elevations in pro‑inflammatory cytokines (TNF‑α, IL‑6, IL‑17, IL‑1β, MIF) and bone‑destructive factors (DKK‑1 ...
Xiaogang Zhang, Mingming Zhang, Zhiqiang Wang, Jie Bai, Xing Feng, Yajing Wang, Zhenbin Li, Dongbao Zhao   +7 more
wiley   +1 more source

Melatonin Suppresses Osteoclastogenesis via Inhibiting Iron/ROS-CREB/PGC-1β-Mediated Mitochondrial Biogenesis. [PDF]

J Pineal Res
Yang J, Che J, Yang M, Feng Y, Li Q, Zeng Y.   +5 more
europepmc   +1 more source

Treg‐stromal cell axis in tissue repair and autoimmune diseases: Mechanisms and clinical translation

Rheumatology &Autoimmunity, EarlyView.
The Treg‐stromal cell axis as a central regulator of tissue repair and immune tolerance. Under physiological conditions, bidirectional communication between Tregs and stromal cells—mediated by cell‐surface molecular contacts, anti‐inflammatory cytokines, and extracellular vesicles—orchestrates inflammation resolution, immune tolerance, and complete ...
Peiyan Zhang, Rongyuan Gao, Zhaohui Zheng   +2 more
wiley   +1 more source

Clinically relevant intra-articular corticosteroid doses impair equine osteoclast function in vitro. [PDF]

Vet Surg
Malek G, Kamus L, Richard H, Beauchamp G, Laverty S.   +4 more
europepmc   +1 more source

Engineering Flexible Nanofibrous Hydroxyapatite Scaffolds With Tunable Degradation and Mechanical Properties for Bone Regeneration

Small, EarlyView.
Conventional hydroxyapatite ceramics are brittle and poorly resorbable, limiting their use in bone repair. To overcome these limitations, flexible scaffolds are fabricated using ceramic nanofibers as structural building blocks. Adjusting nanofiber characteristics allows modulating the mechanical properties and degradation, providing a versatile ...
Raúl Agut López, Ignacio Ridao Laguna, Cristián Huck‐Iriart, Maria‐Pau Ginebra, Montserrat Espanol   +4 more
wiley   +1 more source