Results 171 to 180 of about 132,120 (348)

Loss of myocyte enhancer factor 2 expression in osteoclasts leads to opposing skeletal phenotypes

, 2020
Nicholas Blixt, Andrew Norton, Anqi Zhang, Conrado Aparicio, Hari Prasad, Rajaram Gopalakrishnan, Eric D. Jensen, Kim C. Mansky   +7 more
openalex   +2 more sources

Possible role of microtubules in vesicular transport of matrix protein during sea urchin larval biomineralization

Developmental Dynamics, EarlyView.
Abstract Background Biomineralization is a vital biological process through which organisms produce mineralized structures such as shells, skeletons, and teeth. Microtubules are essential for biomineralization in various eukaryotic species; however, their specific roles in this process remain unclear.
Areen Qassem, Tsvia Gildor, Smadar Ben‐Tabou de‐Leon   +2 more
wiley   +1 more source

Vascular Calcification: Mechanisms, Models, and Therapies

iNew Medicine, EarlyView.
ABSTRACT Vascular calcification represents an active multifactorial process that mirrors several key features of skeletal bone mineralization. Clinically, it is characterized by diminished arterial compliance and increased arterial wall stiffness, both of which serve as independent predictors of significant adverse cardiovascular events.
Wenya Zhu, Shu Yang, Ziyi Chen, Xiaoxiao Yang, Zhen Liang, Yuanli Chen   +5 more
wiley   +1 more source

The Role of Endothelin‐1 in Autoimmune Diseases: Mechanistic Insights and Therapeutic Targets

iNew Medicine, EarlyView.
The Role of Endothelin‐1 in Autoimmune Diseases. NF‐κB: nuclear factor kappa‐B; MAPK: mitogen‐activated protein kinase; PI3K: phosphoinositide 3‐kinase; ROS: reactive oxygen species; CTGF: connective tissue growth factor; TGF‐β: transforming growth factor‐β.
Xun Gong, Zhenyu Wang, Suyin Yang, Kaige Gao, Xin Yang, Min Tang   +5 more
wiley   +1 more source

Path Analysis Results on Bone Markers That Influence Accelerated Bone Remodeling: An Experimental Study. [PDF]

Clin Exp Dent Res
Dewi RK, Oktawati S, Gani A, Suhartono E, Hamrun N, Samad R, Natsir N, Apriasari ML, Hasanuddin H.   +8 more
europepmc   +1 more source

Hyperglycemia Suppresses RANKL-Induced Osteoclast Differentiation through LXRβ Expression in RAW264.7 Cells

, 2017
Teruyoshi Tanaka, Yuichiro Takei, Nobuhiro Zaima, Tatsuya Moriyama, Dai Yamanouchi   +4 more
openalex   +2 more sources

Plant‐derived extracellular vesicle‐like particles as novel osteoanabolic agents: Activating bone morphogenetic protein 2/Smads signaling axis for bone regeneration in postmenopausal osteoporosis

Interdisciplinary Medicine, EarlyView.
Illustration depicting the isolation of Dipsaci Radix derived extracellular vesicle‐like particles and their function in alleviating osteoporosis. (A) Extraction and characterization detection process of extracellular vesicle‐like particles derived from Dipsaci Radix roots. (B) Cell experiments in vitro, Dipsaci Radix derived extracellular vesicle‐like
Qing Zhao, Yue Cao, Zhengting Wu, Yingqi Cao, Qi You, Yuanyuan Xia, Xuejun Tan, Dongxiao Li, Tianxin Qiu, Xiuping Cai, Zhaodi Guo, Lei Zheng, Kewei Zhao   +12 more
wiley   +1 more source

#1865 The role of osteoclast-associated receptor in phosphorus metabolism via salivary-bone-kidney interaction [PDF]

Hiroyuki Tamaki, Masahiro Eriguchi, Takayuki Uemura, Tasaki Hikari, Masatoshi Nishimoto, Takaaki Kosugi, Hideo Tsushima, Ken‐ichi Samejima, Kazuhiko Tsuruya   +8 more
openalex   +1 more source

SUMOylation regulates tumorigenesis and progression: Molecular mechanisms and therapeutic applications

Interdisciplinary Medicine, EarlyView.
SUMOylation, a dynamic post‐translational modification, acts as a master regulator at the heart of tumor malignancy. Our work delineates how the SUMOylation cycle—mediated by E1/E2/E3 enzymes and reversed by SENPs—orchestrates multiple hallmarks of cancer. The central pathway converges on three critical pathological axes: 1.
Yimao Wu, Zichang Chen, Yinting Hu, Gokhan Zengin, Qian Zhang, Meng‐Yao Li, Wenlong Sun   +6 more
wiley   +1 more source

Spectrum and functions of ion channels and transporters in osteoclasts. [PDF]

Bone Res
Chen H, Zhang Y, Zhu Y, Xiao X, Huang S, Duan X.   +5 more
europepmc   +1 more source